CFB complement factor B [Macaca mulatta (Rhesus monkey)] - Gene

Summary

Gene symbol: CFB
Gene description: complement factor B
See related: Ensembl:ENSMMUG00000000729
Gene type: protein coding
RefSeq status: MODEL
Organism: Macaca mulatta
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 4

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
103	current	Mmul_10 (GCF_003339765.1)	4	NC_041757.1 (137543938..137549958, complement)
102	previous assembly	Mmul_8.0.1 (GCF_000772875.2)	4	NC_027896.1 (32833410..32839428)

Chromosome 4 - NC_041757.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH46865 (e-PCR)
- UniSTS:13369

SHGC-12705 (e-PCR)
- UniSTS:38784

SGC32658 (e-PCR)
- UniSTS:45443

RDBP_8772 (e-PCR)
- UniSTS:467858

C2_3011 (e-PCR)
- UniSTS:280470

RH18075 (e-PCR)
- UniSTS:72393

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in complement activation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in proteolysis	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: complement factor B

Names: complement factor B preproprotein

XP_014991515.2

EC 3.4.21.47

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

NC_041757.1 Reference Mmul_10 Primary Assembly

Range

137543938..137549958 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_015136029.2 → XP_014991515.2 complement factor B

UniProtKB/TrEMBL

F6YJY7, G7MRL4, H9ZC51

Related

ENSMMUP00000000985.4, ENSMMUT00000001051.4

Conserved Domains (4) summary

cd00033
Location:103 → 158

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

PHA02927
Location:55 → 218

PHA02927; secreted complement-binding protein; Provisional

cd00190
Location:488 → 754

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

cd01470
Location:269 → 465

vWA_complement_factors; Complement factors B and C2 are two critical proteases for complement activation. They both contain three CCP or Sushi domains, a trypsin-type serine protease domain and a single VWA domain with a conserved metal ion dependent adhesion site referred ...