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PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [ Macaca mulatta (Rhesus monkey) ]

Gene ID: 716098, updated on 17-Aug-2024

Summary

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Official Symbol
PIK3CBprovided by VGNC
Official Full Name
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit betaprovided by VGNC
Primary source
VGNC:VGNC:75996
Locus tag
EGK_12063
See related
Ensembl:ENSMMUG00000008666
Gene type
protein coding
RefSeq status
MODEL
Organism
Macaca mulatta
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs
human mouse all
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Genomic context

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See PIK3CB in Genome Data Viewer
Location:
chromosome: 2
Exon count:
24
Annotation release Status Assembly Chr Location
103 current Mmul_10 (GCF_003339765.1) 2 NC_041755.1 (40812861..40998314, complement)
102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 2 NC_027894.1 (163115003..163306449)

Chromosome 2 - NC_041755.1Genomic Context describing neighboring genes Neighboring gene centrosomal protein 70 Neighboring gene Fas apoptotic inhibitory molecule Neighboring gene elongation factor 1-alpha 1 pseudogene Neighboring gene ATP synthase F(0) complex subunit C1, mitochondrial-like Neighboring gene FOXL2 neighbor Neighboring gene forkhead box L2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables 1-phosphatidylinositol-3-kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables 1-phosphatidylinositol-4-phosphate 3-kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell migration IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in phosphatidylinositol-3-phosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in phosphatidylinositol-mediated signaling IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of phosphatidylinositol 3-kinase complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
Names
phosphoinositide-3-kinase, catalytic, beta polypeptide
XP_014987568.1
XP_028699574.1
XP_028699575.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

  1. NC_041755.1 Reference Mmul_10 Primary Assembly

    Range
    40812861..40998314 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_028843741.1 → XP_028699574.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1

    UniProtKB/TrEMBL
    A0A663DHT5, A0A8J8XK18, F7F3S0, G7MJN7, H9F0X6
    Conserved Domains (5) summary
    cd08693
    Location:324 → 501
    C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
    smart00143
    Location:41 → 118
    PI3K_p85B; PI3-kinase family, p85-binding domain
    cd00872
    Location:532 → 702
    PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...
    cd05173
    Location:706 → 1067
    PI3Kc_IA_beta; Catalytic domain of Class IA Phosphoinositide 3-kinase beta
    pfam00794
    Location:180 → 288
    PI3K_rbd; PI3-kinase family, ras-binding domain

  2. XM_028843742.1 → XP_028699575.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X2

    UniProtKB/TrEMBL
    H9F0X6
    Conserved Domains (5) summary
    smart00143
    Location:41 → 118
    PI3K_p85B; PI3-kinase family, p85-binding domain
    cd00872
    Location:470 → 640
    PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...
    cd05173
    Location:644 → 1005
    PI3Kc_IA_beta; Catalytic domain of Class IA Phosphoinositide 3-kinase beta
    pfam00794
    Location:180 → 288
    PI3K_rbd; PI3-kinase family, ras-binding domain
    cl14603
    Location:324 → 439
    C2; C2 domain

  3. XM_015132082.2 → XP_014987568.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1

    UniProtKB/TrEMBL
    A0A663DHT5, A0A8J8XK18, F7F3S0, G7MJN7, H9F0X6
    Related
    ENSMMUP00000011365.3, ENSMMUT00000012114.4
    Conserved Domains (5) summary
    cd08693
    Location:324 → 501
    C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
    smart00143
    Location:41 → 118
    PI3K_p85B; PI3-kinase family, p85-binding domain
    cd00872
    Location:532 → 702
    PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...
    cd05173
    Location:706 → 1067
    PI3Kc_IA_beta; Catalytic domain of Class IA Phosphoinositide 3-kinase beta
    pfam00794
    Location:180 → 288
    PI3K_rbd; PI3-kinase family, ras-binding domain
Nucleotide Protein
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