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FASN fatty acid synthase [ Macaca mulatta (Rhesus monkey) ]

Gene ID: 715708, updated on 17-Aug-2024

Summary

Official Symbol
FASNprovided by VGNC
Official Full Name
fatty acid synthaseprovided by VGNC
Primary source
VGNC:VGNC:72616
See related
Ensembl:ENSMMUG00000012811
Gene type
protein coding
RefSeq status
MODEL
Organism
Macaca mulatta
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs
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Genomic context

See FASN in Genome Data Viewer
Location:
chromosome: 16
Exon count:
43
Annotation release Status Assembly Chr Location
103 current Mmul_10 (GCF_003339765.1) 16 NC_041769.1 (78420668..78440909, complement)
102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 16 NC_027908.1 (75955211..75975454, complement)

Chromosome 16 - NC_041769.1Genomic Context describing neighboring genes Neighboring gene G protein pathway suppressor 1 Neighboring gene dihydrouridine synthase 1 like Neighboring gene coiled-coil domain containing 57 Neighboring gene small nucleolar RNA U13 Neighboring gene solute carrier family 16 member 3 Neighboring gene casein kinase 1 delta

Genomic regions, transcripts, and products

General gene information

Markers

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables 3-oxoacyl-[acyl-carrier-protein] synthase activity IEA
Inferred from Electronic Annotation
more info
PubMed 
enables fatty acid synthase activity IEA
Inferred from Electronic Annotation
more info
PubMed 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
PubMed 
enables phosphopantetheine binding IEA
Inferred from Electronic Annotation
more info
PubMed 
Process Evidence Code Pubs
involved_in fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

  1. NC_041769.1 Reference Mmul_10 Primary Assembly

    Range
    78420668..78440909 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015120627.2XP_014976113.1  fatty acid synthase

    UniProtKB/TrEMBL
    A0A5K1UCR4, H9FR77, H9Z6B5
    Related
    ENSMMUP00000016836.4, ENSMMUT00000017977.4
    Conserved Domains (11) summary
    cd05195
    Location:15661853
    enoyl_red; enoyl reductase of polyketide synthase
    cd08954
    Location:18752111
    KR_1_FAS_SDR_x; beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 1, complex (x) SDRs
    smart00823
    Location:21102178
    PKS_PP; Phosphopantetheine attachment site
    smart00829
    Location:15641853
    PKS_ER; Enoylreductase
    COG3321
    Location:11042
    PksD; Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites biosynthesis, transport and catabolism]
    cd00833
    Location:2404
    PKS; polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or ...
    pfam00698
    Location:493810
    Acyl_transf_1; Acyl transferase domain
    pfam00975
    Location:22412500
    Thioesterase; Thioesterase domain
    pfam08242
    Location:12431342
    Methyltransf_12; Methyltransferase domain
    pfam16197
    Location:362474
    KAsynt_C_assoc; Ketoacyl-synthetase C-terminal extension
    cl00509
    Location:8741080
    hot_dog; The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated ...