U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

KALRN kalirin RhoGEF kinase [ Macaca mulatta (Rhesus monkey) ]

Gene ID: 715567, updated on 17-Aug-2024

Summary

Go to the top of the page Help
Official Symbol
KALRNprovided by VGNC
Official Full Name
kalirin RhoGEF kinaseprovided by VGNC
Primary source
VGNC:VGNC:84161
See related
Ensembl:ENSMMUG00000003851
Gene type
protein coding
RefSeq status
MODEL
Organism
Macaca mulatta
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See KALRN in Genome Data Viewer
Location:
chromosome: 2
Exon count:
63
Annotation release Status Assembly Chr Location
103 current Mmul_10 (GCF_003339765.1) 2 NC_041755.1 (151580354..152273292, complement)
102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 2 NC_027894.1 (45272761..45964642)

Chromosome 2 - NC_041755.1Genomic Context describing neighboring genes Neighboring gene integrin subunit beta 5 Neighboring gene uncharacterized LOC114676414 Neighboring gene uridine monophosphate synthetase Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC106996799 Neighboring gene uncharacterized LOC114676415 Neighboring gene 60S ribosomal protein L7 pseudogene Neighboring gene uncharacterized LOC114676416 Neighboring gene rhophilin associated tail protein 1 Neighboring gene coiled-coil domain containing 14

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in axon guidance IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in postsynaptic density IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
kalirin
XP_014985513.1
XP_014985514.1
XP_014985515.1
XP_014985516.1
XP_014985518.1
XP_014985519.1
XP_014985520.1
XP_014985521.1
XP_014985522.1
XP_014985523.1
XP_014985524.1
XP_014985525.1
XP_014985527.1
XP_014985529.1
XP_014985530.1
XP_028700388.1
XP_028700389.1
XP_028700390.1
XP_028700391.1
XP_028700392.1
XP_028700393.1
XP_028700396.1
XP_028700397.1
XP_028700398.1
XP_028700399.1
XP_028700400.1
XP_028700401.1
XP_028700402.1
XP_028700403.1
XP_028700404.1
XP_028700405.1
XP_028700406.1
XP_028700407.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

  1. NC_041755.1 Reference Mmul_10 Primary Assembly

    Range
    151580354..152273292 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015130036.2 → XP_014985522.1  kalirin isoform X10

    UniProtKB/TrEMBL
    G7MKL1
    Conserved Domains (16) summary
    cd00096
    Location:2468 → 2542
    Ig; Immunoglobulin domain
    cd11852
    Location:1629 → 1688
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:2305 → 2363
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00220
    Location:2664 → 2918
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    smart00516
    Location:41 → 179
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00063
    Location:2549 → 2640
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00160
    Location:1264 → 1434
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:539 → 755
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam07679
    Location:2451 → 2545
    I-set; Immunoglobulin I-set domain
    cd13240
    Location:1441 → 1563
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:2087 → 2221
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14115
    Location:2670 → 2917
    STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
    pfam00169
    Location:1474 → 1559
    PH; PH domain
    pfam00621
    Location:1913 → 2083
    RhoGEF; RhoGEF domain
    pfam16609
    Location:1686 → 1912
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    cl02488
    Location:1111 → 1280
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  2. XM_015130035.2 → XP_014985521.1  kalirin isoform X8

    UniProtKB/TrEMBL
    G7MKL1
    Conserved Domains (16) summary
    cd00096
    Location:2477 → 2551
    Ig; Immunoglobulin domain
    cd11852
    Location:1638 → 1697
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:2314 → 2372
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00220
    Location:2673 → 2927
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    smart00516
    Location:41 → 179
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00063
    Location:2558 → 2649
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00160
    Location:1273 → 1443
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:539 → 755
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam07679
    Location:2460 → 2554
    I-set; Immunoglobulin I-set domain
    cd13240
    Location:1450 → 1572
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:2096 → 2230
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14115
    Location:2679 → 2926
    STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
    pfam00169
    Location:1483 → 1568
    PH; PH domain
    pfam00621
    Location:1922 → 2092
    RhoGEF; RhoGEF domain
    pfam16609
    Location:1695 → 1921
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    cl02488
    Location:1088 → 1227
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  3. XM_015130038.2 → XP_014985524.1  kalirin isoform X12

    UniProtKB/TrEMBL
    G7MKL1
    Conserved Domains (16) summary
    cd00096
    Location:2457 → 2531
    Ig; Immunoglobulin domain
    cd11852
    Location:1651 → 1710
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:2294 → 2352
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00220
    Location:2653 → 2907
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    smart00516
    Location:41 → 179
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00063
    Location:2538 → 2629
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00160
    Location:1286 → 1456
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:539 → 768
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam07679
    Location:2440 → 2534
    I-set; Immunoglobulin I-set domain
    cd13240
    Location:1463 → 1585
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:2076 → 2210
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14115
    Location:2659 → 2906
    STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
    pfam00169
    Location:1496 → 1581
    PH; PH domain
    pfam00621
    Location:1902 → 2072
    RhoGEF; RhoGEF domain
    pfam16609
    Location:1708 → 1846
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    cl02488
    Location:1101 → 1240
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  4. XM_015130029.2 → XP_014985515.1  kalirin isoform X3

    UniProtKB/TrEMBL
    G7MKL1
    Conserved Domains (16) summary
    cd00096
    Location:2489 → 2563
    Ig; Immunoglobulin domain
    cd11852
    Location:1651 → 1710
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:2326 → 2384
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00220
    Location:2685 → 2939
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    smart00516
    Location:41 → 179
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00063
    Location:2570 → 2661
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00160
    Location:1286 → 1456
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:539 → 768
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam07679
    Location:2472 → 2566
    I-set; Immunoglobulin I-set domain
    cd13240
    Location:1463 → 1585
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:2108 → 2242
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14115
    Location:2691 → 2938
    STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
    pfam00169
    Location:1496 → 1581
    PH; PH domain
    pfam00621
    Location:1934 → 2104
    RhoGEF; RhoGEF domain
    pfam16609
    Location:1708 → 1933
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    cl02488
    Location:1101 → 1240
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  5. XM_015130037.2 → XP_014985523.1  kalirin isoform X11

    UniProtKB/TrEMBL
    G7MKL1
    Conserved Domains (16) summary
    cd00096
    Location:2458 → 2532
    Ig; Immunoglobulin domain
    cd11852
    Location:1651 → 1710
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:2295 → 2353
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00220
    Location:2654 → 2908
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    smart00516
    Location:41 → 179
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00063
    Location:2539 → 2630
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00160
    Location:1286 → 1456
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:539 → 768
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam07679
    Location:2441 → 2535
    I-set; Immunoglobulin I-set domain
    cd13240
    Location:1463 → 1585
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:2077 → 2211
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14115
    Location:2660 → 2907
    STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
    pfam00169
    Location:1496 → 1581
    PH; PH domain
    pfam00621
    Location:1903 → 2073
    RhoGEF; RhoGEF domain
    pfam16609
    Location:1708 → 1847
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    cl02488
    Location:1101 → 1240
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  6. XM_015130027.2 → XP_014985513.1  kalirin isoform X1

    UniProtKB/TrEMBL
    G7MKL1
    Conserved Domains (16) summary
    cd00096
    Location:2490 → 2564
    Ig; Immunoglobulin domain
    cd11852
    Location:1651 → 1710
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:2327 → 2385
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00220
    Location:2686 → 2940
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    smart00516
    Location:41 → 179
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00063
    Location:2571 → 2662
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00160
    Location:1286 → 1456
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:539 → 768
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam07679
    Location:2473 → 2567
    I-set; Immunoglobulin I-set domain
    cd13240
    Location:1463 → 1585
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:2109 → 2243
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14115
    Location:2692 → 2939
    STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
    pfam00169
    Location:1496 → 1581
    PH; PH domain
    pfam00621
    Location:1935 → 2105
    RhoGEF; RhoGEF domain
    pfam16609
    Location:1708 → 1934
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    cl02488
    Location:1101 → 1240
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  7. XM_028844555.1 → XP_028700388.1  kalirin isoform X9

    UniProtKB/TrEMBL
    G7MKL1
    Conserved Domains (13) summary
    smart00150
    Location:1137 → 1237
    SPEC; Spectrin repeats
    cd11852
    Location:1651 → 1710
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:2327 → 2385
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:41 → 179
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00063
    Location:2551 → 2642
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00160
    Location:1286 → 1456
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:539 → 768
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:1463 → 1585
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:2109 → 2243
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14115
    Location:2672 → 2919
    STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
    pfam00621
    Location:1935 → 2104
    RhoGEF; RhoGEF domain
    pfam16609
    Location:1708 → 1892
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    pfam07679
    Location:2453 → 2547
    I-set; Immunoglobulin I-set domain

  8. XM_015130028.2 → XP_014985514.1  kalirin isoform X2

    UniProtKB/TrEMBL
    F6VU49, G7MKL1
    Related
    ENSMMUP00000021925.4, ENSMMUT00000023431.4
    Conserved Domains (13) summary
    smart00150
    Location:1137 → 1237
    SPEC; Spectrin repeats
    cd11852
    Location:1651 → 1710
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:2326 → 2384
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:41 → 179
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00063
    Location:2570 → 2661
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00160
    Location:1286 → 1456
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:539 → 768
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:1463 → 1585
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:2109 → 2243
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14115
    Location:2691 → 2938
    STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
    pfam00621
    Location:1935 → 2104
    RhoGEF; RhoGEF domain
    pfam07679
    Location:2472 → 2566
    I-set; Immunoglobulin I-set domain
    pfam16609
    Location:1708 → 1925
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region

  9. XM_015130044.2 → XP_014985530.1  kalirin isoform X27

    Conserved Domains (9) summary
    cd00096
    Location:791 → 865
    Ig; Immunoglobulin domain
    cd11853
    Location:628 → 686
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00220
    Location:987 → 1241
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00063
    Location:872 → 963
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:774 → 868
    I-set; Immunoglobulin I-set domain
    cd13241
    Location:410 → 544
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14115
    Location:993 → 1240
    STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
    pfam00621
    Location:236 → 406
    RhoGEF; RhoGEF domain
    pfam16609
    Location:25 → 235
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region

  10. XM_015130033.2 → XP_014985519.1  kalirin isoform X6

    UniProtKB/TrEMBL
    G7MKL1
    Conserved Domains (16) summary
    cd00096
    Location:2481 → 2555
    Ig; Immunoglobulin domain
    cd11852
    Location:1642 → 1701
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:2318 → 2376
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00220
    Location:2677 → 2931
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    smart00516
    Location:41 → 179
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00063
    Location:2562 → 2653
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00160
    Location:1277 → 1447
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:893 → 1122
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam07679
    Location:2464 → 2558
    I-set; Immunoglobulin I-set domain
    cd13240
    Location:1454 → 1576
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:2100 → 2234
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14115
    Location:2683 → 2930
    STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
    pfam00169
    Location:1487 → 1572
    PH; PH domain
    pfam00621
    Location:1926 → 2096
    RhoGEF; RhoGEF domain
    pfam16609
    Location:1699 → 1925
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    cl02488
    Location:1124 → 1293
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  11. XM_015130030.2 → XP_014985516.1  kalirin isoform X4

    UniProtKB/TrEMBL
    G7MKL1
    Conserved Domains (16) summary
    cd00096
    Location:2488 → 2562
    Ig; Immunoglobulin domain
    cd11852
    Location:1649 → 1708
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:2325 → 2383
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00220
    Location:2684 → 2938
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    smart00516
    Location:39 → 177
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00063
    Location:2569 → 2660
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00160
    Location:1284 → 1454
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:537 → 766
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam07679
    Location:2471 → 2565
    I-set; Immunoglobulin I-set domain
    cd13240
    Location:1461 → 1583
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:2107 → 2241
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14115
    Location:2690 → 2937
    STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
    pfam00169
    Location:1494 → 1579
    PH; PH domain
    pfam00621
    Location:1933 → 2103
    RhoGEF; RhoGEF domain
    pfam16609
    Location:1706 → 1932
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    cl02488
    Location:1099 → 1238
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  12. XM_015130034.2 → XP_014985520.1  kalirin isoform X7

    UniProtKB/TrEMBL
    G7MKL1
    Conserved Domains (16) summary
    cd00096
    Location:2479 → 2553
    Ig; Immunoglobulin domain
    cd11852
    Location:1640 → 1699
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:2316 → 2374
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00220
    Location:2675 → 2929
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    smart00516
    Location:39 → 177
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00063
    Location:2560 → 2651
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00160
    Location:1275 → 1445
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:891 → 1120
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam07679
    Location:2462 → 2556
    I-set; Immunoglobulin I-set domain
    cd13240
    Location:1452 → 1574
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:2098 → 2232
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14115
    Location:2681 → 2928
    STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
    pfam00169
    Location:1485 → 1570
    PH; PH domain
    pfam00621
    Location:1924 → 2094
    RhoGEF; RhoGEF domain
    pfam16609
    Location:1697 → 1923
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    cl02488
    Location:1122 → 1291
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  13. XM_015130032.2 → XP_014985518.1  kalirin isoform X5

    UniProtKB/TrEMBL
    A0A1D5QWV4, G7MKL1
    Related
    ENSMMUP00000052534.2, ENSMMUT00000075381.2
    Conserved Domains (13) summary
    smart00150
    Location:1135 → 1235
    SPEC; Spectrin repeats
    cd11852
    Location:1649 → 1708
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:2324 → 2382
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:39 → 177
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00063
    Location:2568 → 2659
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00160
    Location:1284 → 1454
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:537 → 766
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:1461 → 1583
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:2107 → 2241
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14115
    Location:2689 → 2936
    STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
    pfam00621
    Location:1933 → 2102
    RhoGEF; RhoGEF domain
    pfam07679
    Location:2470 → 2564
    I-set; Immunoglobulin I-set domain
    pfam16609
    Location:1706 → 1923
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region

  14. XM_028844569.1 → XP_028700402.1  kalirin isoform X28

    UniProtKB/TrEMBL
    F6VU54
    Related
    ENSMMUP00000021924.4, ENSMMUT00000023430.4
    Conserved Domains (8) summary
    cd11853
    Location:627 → 685
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd00063
    Location:871 → 962
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd13241
    Location:410 → 544
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14115
    Location:992 → 1239
    STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin
    pfam00621
    Location:236 → 405
    RhoGEF; RhoGEF domain
    pfam07679
    Location:773 → 867
    I-set; Immunoglobulin I-set domain
    pfam16609
    Location:25 → 235
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    cd00096
    Location:765 → 768
    Ig; Ig strand A [structural motif]

  15. XM_015130039.2 → XP_014985525.1  kalirin isoform X13

    UniProtKB/TrEMBL
    G7MKL1
    Conserved Domains (14) summary
    cd00096
    Location:2490 → 2564
    Ig; Immunoglobulin domain
    cd11852
    Location:1651 → 1710
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:2327 → 2385
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:41 → 179
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00063
    Location:2571 → 2662
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00160
    Location:1286 → 1456
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:539 → 768
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam07679
    Location:2473 → 2567
    I-set; Immunoglobulin I-set domain
    cd13240
    Location:1463 → 1585
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:2109 → 2243
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    pfam00169
    Location:1496 → 1581
    PH; PH domain
    pfam00621
    Location:1935 → 2105
    RhoGEF; RhoGEF domain
    pfam16609
    Location:1708 → 1934
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    cl02488
    Location:1101 → 1240
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  16. XM_028844556.1 → XP_028700389.1  kalirin isoform X14

    Conserved Domains (11) summary
    smart00150
    Location:1137 → 1237
    SPEC; Spectrin repeats
    cd11852
    Location:1651 → 1710
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:2327 → 2385
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:41 → 179
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:1286 → 1456
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:539 → 768
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:1463 → 1585
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:2109 → 2243
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    pfam00621
    Location:1935 → 2104
    RhoGEF; RhoGEF domain
    pfam12297
    Location:793 → 945
    EVC2_like; Ellis van Creveld protein 2 like protein
    pfam16609
    Location:1708 → 1892
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region

  17. XM_028844559.1 → XP_028700392.1  kalirin isoform X18

    Conserved Domains (10) summary
    smart00150
    Location:1128 → 1228
    SPEC; Spectrin repeats
    cd11852
    Location:1642 → 1701
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:2284 → 2342
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:41 → 179
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:1277 → 1447
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:893 → 1122
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:1454 → 1576
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:2067 → 2201
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    pfam00621
    Location:1893 → 2062
    RhoGEF; RhoGEF domain
    pfam16609
    Location:1699 → 1837
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region

  18. XM_028844557.1 → XP_028700390.1  kalirin isoform X15

    Conserved Domains (10) summary
    smart00150
    Location:1137 → 1237
    SPEC; Spectrin repeats
    cd11852
    Location:1651 → 1710
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:2325 → 2383
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:41 → 179
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:1286 → 1456
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:539 → 768
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:1463 → 1585
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:2108 → 2242
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    pfam00621
    Location:1934 → 2103
    RhoGEF; RhoGEF domain
    pfam16609
    Location:1708 → 1924
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region

  19. XM_015130041.2 → XP_014985527.1  kalirin isoform X17

    Conserved Domains (11) summary
    cd11852
    Location:1651 → 1710
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:2294 → 2352
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:41 → 179
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:1286 → 1456
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:539 → 768
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:1463 → 1585
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:2077 → 2211
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    pfam00169
    Location:1496 → 1581
    PH; PH domain
    pfam00621
    Location:1903 → 2073
    RhoGEF; RhoGEF domain
    pfam16609
    Location:1708 → 1847
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    cl02488
    Location:1101 → 1240
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  20. XM_028844558.1 → XP_028700391.1  kalirin isoform X16

    UniProtKB/TrEMBL
    G7MKL1
    Conserved Domains (10) summary
    smart00150
    Location:1135 → 1235
    SPEC; Spectrin repeats
    cd11852
    Location:1649 → 1708
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:2323 → 2381
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:39 → 177
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:1284 → 1454
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:537 → 766
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:1461 → 1583
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:2106 → 2240
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    pfam00621
    Location:1932 → 2101
    RhoGEF; RhoGEF domain
    pfam16609
    Location:1706 → 1931
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region

  21. XM_028844574.1 → XP_028700407.1  kalirin isoform X33

    Conserved Domains (4) summary
    cd11853
    Location:594 → 652
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd13241
    Location:377 → 511
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    pfam00621
    Location:203 → 372
    RhoGEF; RhoGEF domain
    pfam16609
    Location:25 → 147
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region

  22. XM_028844573.1 → XP_028700406.1  kalirin isoform X32

    Conserved Domains (4) summary
    cd11853
    Location:595 → 653
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd13241
    Location:377 → 511
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    pfam00621
    Location:203 → 372
    RhoGEF; RhoGEF domain
    pfam16609
    Location:25 → 147
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region

  23. XM_028844570.1 → XP_028700403.1  kalirin isoform X29

    Conserved Domains (4) summary
    cd11853
    Location:626 → 684
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd13241
    Location:409 → 543
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    pfam00621
    Location:235 → 404
    RhoGEF; RhoGEF domain
    pfam16609
    Location:25 → 234
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region

  24. XM_028844572.1 → XP_028700405.1  kalirin isoform X31

    Conserved Domains (4) summary
    cd11853
    Location:595 → 653
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd13241
    Location:378 → 512
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    pfam00621
    Location:204 → 373
    RhoGEF; RhoGEF domain
    pfam16609
    Location:25 → 148
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region

  25. XM_028844571.1 → XP_028700404.1  kalirin isoform X30

    Conserved Domains (4) summary
    cd11853
    Location:596 → 654
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd13241
    Location:378 → 512
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    pfam00621
    Location:204 → 373
    RhoGEF; RhoGEF domain
    pfam16609
    Location:25 → 148
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region

  26. XM_028844560.1 → XP_028700393.1  kalirin isoform X19

    UniProtKB/TrEMBL
    A0A1D5RDL8
    Conserved Domains (5) summary
    smart00150
    Location:1137 → 1237
    SPEC; Spectrin repeats
    smart00516
    Location:41 → 179
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:1286 → 1456
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:539 → 768
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:1463 → 1585
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

  27. XM_028844568.1 → XP_028700401.1  kalirin isoform X26

    UniProtKB/TrEMBL
    A0A1D5RDL8
    Conserved Domains (5) summary
    smart00150
    Location:1113 → 1213
    SPEC; Spectrin repeats
    smart00516
    Location:39 → 177
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:1262 → 1432
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:537 → 753
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:1439 → 1561
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

  28. XM_028844566.1 → XP_028700399.1  kalirin isoform X24

    UniProtKB/TrEMBL
    A0A1D5RDL8
    Conserved Domains (5) summary
    smart00150
    Location:1122 → 1222
    SPEC; Spectrin repeats
    smart00516
    Location:39 → 177
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:1271 → 1441
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:537 → 753
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:1448 → 1570
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

  29. XM_028844564.1 → XP_028700397.1  kalirin isoform X22

    UniProtKB/TrEMBL
    A0A1D5RDL8
    Conserved Domains (5) summary
    smart00150
    Location:1126 → 1226
    SPEC; Spectrin repeats
    smart00516
    Location:39 → 177
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:1275 → 1445
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:891 → 1120
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:1452 → 1574
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

  30. XM_015130043.2 → XP_014985529.1  kalirin isoform X20

    UniProtKB/TrEMBL
    A0A1D5RDL8, F7HAC1, H9G1H6
    Related
    ENSMMUP00000005133.4, ENSMMUT00000005453.4
    Conserved Domains (5) summary
    smart00150
    Location:1135 → 1235
    SPEC; Spectrin repeats
    smart00516
    Location:39 → 177
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:1284 → 1454
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:537 → 766
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:1461 → 1583
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

  31. XM_028844567.1 → XP_028700400.1  kalirin isoform X25

    UniProtKB/TrEMBL
    A0A1D5RDL8
    Conserved Domains (5) summary
    smart00150
    Location:1115 → 1215
    SPEC; Spectrin repeats
    smart00516
    Location:41 → 179
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:1264 → 1434
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:539 → 755
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:1441 → 1563
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

  32. XM_028844565.1 → XP_028700398.1  kalirin isoform X23

    UniProtKB/TrEMBL
    A0A1D5RDL8
    Conserved Domains (5) summary
    smart00150
    Location:1124 → 1224
    SPEC; Spectrin repeats
    smart00516
    Location:41 → 179
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:1273 → 1443
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:539 → 755
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:1450 → 1572
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

  33. XM_028844563.1 → XP_028700396.1  kalirin isoform X21

    UniProtKB/TrEMBL
    A0A1D5RDL8
    Conserved Domains (5) summary
    smart00150
    Location:1128 → 1228
    SPEC; Spectrin repeats
    smart00516
    Location:41 → 179
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:1277 → 1447
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:893 → 1122
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:1454 → 1576
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.