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VARS1 valyl-tRNA synthetase 1 [ Macaca mulatta (Rhesus monkey) ]

Gene ID: 715537, updated on 17-Aug-2024

Summary

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Official Symbol
VARS1provided by VGNC
Official Full Name
valyl-tRNA synthetase 1provided by VGNC
Primary source
VGNC:VGNC:78755
Locus tag
EGK_14727
See related
Ensembl:ENSMMUG00000006828
Gene type
protein coding
RefSeq status
MODEL
Organism
Macaca mulatta
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Also known as
VARS; VARS2; VARS2L
Orthologs
human mouse all
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Genomic context

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See VARS1 in Genome Data Viewer
Location:
chromosome: 4
Exon count:
30
Annotation release Status Assembly Chr Location
103 current Mmul_10 (GCF_003339765.1) 4 NC_041757.1 (137707454..137726508)
102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 4 NC_027896.1 (32645657..32664681, complement)

Chromosome 4 - NC_041757.1Genomic Context describing neighboring genes Neighboring gene heat shock protein family A (Hsp70) member 1A Neighboring gene heat shock protein family A (Hsp70) member 1 like Neighboring gene uncharacterized LOC106997897 Neighboring gene LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated Neighboring gene von Willebrand factor A domain containing 7 Neighboring gene suppressor APC domain containing 1 Neighboring gene mutS homolog 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genomic evolution of MHC class I region in primates. Fukami-Kobayashi K, et al. Proc Natl Acad Sci U S A, 2005 Jun 28. PMID 15967992, Free PMC Article
  2. Rhesus macaque class I duplicon structures, organization, and evolution within the alpha block of the major histocompatibility complex. Kulski JK, et al. Mol Biol Evol, 2004 Nov. PMID 15269276
  3. Rapid evolution of major histocompatibility complex class I genes in primates generates new disease alleles in humans via hitchhiking diversity. Shiina T, et al. Genetics, 2006 Jul. PMID 16702430, Free PMC Article
  4. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
  5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables aminoacyl-tRNA editing activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables valine-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in valyl-tRNA aminoacylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
valine--tRNA ligase, mitochondrial
Names
Valyl-tRNA synthetase, mitochondrial
valine--tRNA ligase
valyl-tRNA synthetase 2, mitochondrial (putative)

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

  1. NC_041757.1 Reference Mmul_10 Primary Assembly

    Range
    137707454..137726508
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015136000.2 → XP_014991486.1  valine--tRNA ligase, mitochondrial isoform X1

    Conserved Domains (7) summary
    cd07962
    Location:939 → 1076
    Anticodon_Ia_Val; Anticodon-binding domain of valyl tRNA synthetases
    cd00817
    Location:336 → 939
    ValRS_core; catalytic core domain of valyl-tRNA synthetases
    cd10294
    Location:92 → 213
    GST_C_ValRS_N; Glutathione S-transferase C-terminal-like, alpha helical domain of vertebrate Valyl-tRNA synthetase
    COG0625
    Location:56 → 203
    GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]
    PTZ00419
    Location:283 → 1265
    PTZ00419; valyl-tRNA synthetase-like protein; Provisional
    pfam10458
    Location:1197 → 1259
    Val_tRNA-synt_C; Valyl tRNA synthetase tRNA binding arm
    pfam13603
    Location:514 → 610
    tRNA-synt_1_2; Leucyl-tRNA synthetase, Domain 2

  2. XM_015136001.2 → XP_014991487.1  valine--tRNA ligase, mitochondrial isoform X2

    UniProtKB/TrEMBL
    A0A5F8A6S7, A0A8J8XAC5, F7GXM4, G7MRK4
    Related
    ENSMMUP00000008979.3, ENSMMUT00000009554.4
    Conserved Domains (7) summary
    cd07962
    Location:938 → 1075
    Anticodon_Ia_Val; Anticodon-binding domain of valyl tRNA synthetases
    cd00817
    Location:335 → 938
    ValRS_core; catalytic core domain of valyl-tRNA synthetases
    cd10294
    Location:92 → 213
    GST_C_ValRS_N; Glutathione S-transferase C-terminal-like, alpha helical domain of vertebrate Valyl-tRNA synthetase
    COG0625
    Location:56 → 203
    GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]
    PTZ00419
    Location:282 → 1264
    PTZ00419; valyl-tRNA synthetase-like protein; Provisional
    pfam10458
    Location:1196 → 1258
    Val_tRNA-synt_C; Valyl tRNA synthetase tRNA binding arm
    pfam13603
    Location:513 → 609
    tRNA-synt_1_2; Leucyl-tRNA synthetase, Domain 2
Nucleotide Protein
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