BACE2 beta-secretase 2 [Macaca mulatta (Rhesus monkey)] - Gene

Summary

Official Symbol: BACE2provided by VGNC
Official Full Name: beta-secretase 2provided by VGNC
Primary source: VGNC:VGNC:70216
See related: Ensembl:ENSMMUG00000004257
Gene type: protein coding
RefSeq status: MODEL
Organism: Macaca mulatta
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 3

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
103	current	Mmul_10 (GCF_003339765.1)	3	NC_041756.1 (5365284..5481257, complement)
102	previous assembly	Mmul_8.0.1 (GCF_000772875.2)	3	NC_027895.1 (5396054..5511760, complement)

Chromosome 3 - NC_041756.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

D21S418E (e-PCR)
- UniSTS:148066

SHGC-52055 (e-PCR)
- UniSTS:78223

RH45177 (e-PCR)
- UniSTS:68012

G20436 (e-PCR)
- UniSTS:3245

A005R16 (e-PCR)
- UniSTS:3246

D21S53 (e-PCR)
- UniSTS:147886

SHGC-87646 (e-PCR)
- UniSTS:35525

RH79591 (e-PCR)
- UniSTS:89803

SHGC-106623 (e-PCR)
- UniSTS:169949

WI-17388 (e-PCR)
- UniSTS:20990

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables aspartic-type endopeptidase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in amyloid-beta metabolic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in membrane protein ectodomain proteolysis	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in endosome	IEA Inferred from Electronic Annotation more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info	PubMed
located_in trans-Golgi network	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: beta-secretase 2

Names: beta-site APP-cleaving enzyme 2

XP_014988337.1

EC 3.4.23.45

XP_014988338.1

EC 3.4.23.45

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

NC_041756.1 Reference Mmul_10 Primary Assembly

Range

5365284..5481257 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_015132852.2 → XP_014988338.1 beta-secretase 2 isoform X2

UniProtKB/TrEMBL

H9F752

Conserved Domains (2) summary

pfam00026
Location:92 → 380

Asp; Eukaryotic aspartyl protease

cl11403
Location:89 → 400

pepsin_retropepsin_like; Cellular and retroviral pepsin-like aspartate proteases
XM_015132851.2 → XP_014988337.1 beta-secretase 2 isoform X1

UniProtKB/TrEMBL

H9F752

Conserved Domains (2) summary

cd05473
Location:89 → 450

beta_secretase_like; Beta-secretase, aspartic-acid protease important in the pathogenesis of Alzheimer's disease

pfam00026
Location:92 → 430

Asp; Eukaryotic aspartyl protease