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PDE10A phosphodiesterase 10A [ Macaca mulatta (Rhesus monkey) ]

Gene ID: 714983, updated on 18-Sep-2024

Summary

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Official Symbol
PDE10Aprovided by VGNC
Official Full Name
phosphodiesterase 10Aprovided by VGNC
Primary source
VGNC:VGNC:75908
See related
Ensembl:ENSMMUG00000023614
Gene type
protein coding
RefSeq status
MODEL
Organism
Macaca mulatta
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs
human mouse all
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Genomic context

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See PDE10A in Genome Data Viewer
Location:
chromosome: 4
Exon count:
33
Annotation release Status Assembly Chr Location
103 current Mmul_10 (GCF_003339765.1) 4 NC_041757.1 (4739016..5415945)
102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 4 NC_027896.1 (166516725..166795430, complement)

Chromosome 4 - NC_041757.1Genomic Context describing neighboring genes Neighboring gene mitochondrial import receptor subunit TOM6 homolog pseudogene Neighboring gene uncharacterized LOC114677372 Neighboring gene putative uncharacterized protein FLJ36797 Neighboring gene putative transcriptional regulator encoded by LINC00473 Neighboring gene uncharacterized LOC106998194 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC106998130 Neighboring gene chromosome 4 C6orf118 homolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables 3',5'-cGMP-stimulated cyclic-nucleotide phosphodiesterase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of cGMP-mediated signaling IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
XP_001105004.2
XP_014993138.1
XP_014993139.1
XP_014993141.1
XP_028702818.1
XP_028702819.1
XP_028702820.1
XP_028702821.1
XP_028702822.1
XP_028702823.1
XP_028702824.1
XP_028702825.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

  1. NC_041757.1 Reference Mmul_10 Primary Assembly

    Range
    4739016..5415945
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_028846987.1 → XP_028702820.1  cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X3

    UniProtKB/TrEMBL
    F7HBA5, G7MR66
    Related
    ENSMMUP00000031087.4, ENSMMUT00000033220.4
    Conserved Domains (3) summary
    smart00065
    Location:294 → 449
    GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
    pfam00233
    Location:541 → 773
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam01590
    Location:118 → 261
    GAF; GAF domain

  2. XM_028846991.1 → XP_028702824.1  cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X7

    UniProtKB/TrEMBL
    A0A5F7ZVN1
    Conserved Domains (3) summary
    smart00065
    Location:197 → 352
    GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
    pfam00233
    Location:444 → 676
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam01590
    Location:21 → 164
    GAF; GAF domain

  3. XM_028846986.1 → XP_028702819.1  cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X2

    UniProtKB/TrEMBL
    G7MR66
    Conserved Domains (3) summary
    smart00065
    Location:335 → 490
    GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
    pfam00233
    Location:582 → 814
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam01590
    Location:159 → 302
    GAF; GAF domain

  4. XM_028846988.1 → XP_028702821.1  cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X3

    UniProtKB/TrEMBL
    F7HBA5, G7MR66
    Conserved Domains (3) summary
    smart00065
    Location:294 → 449
    GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
    pfam00233
    Location:541 → 773
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam01590
    Location:118 → 261
    GAF; GAF domain

  5. XM_028846985.1 → XP_028702818.1  cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X1

    UniProtKB/TrEMBL
    G7MR66
    Conserved Domains (3) summary
    smart00065
    Location:370 → 525
    GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
    pfam00233
    Location:617 → 849
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam01590
    Location:194 → 337
    GAF; GAF domain

  6. XM_028846989.1 → XP_028702822.1  cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X4

    UniProtKB/TrEMBL
    G7MR66
    Conserved Domains (3) summary
    smart00065
    Location:267 → 422
    GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
    pfam00233
    Location:514 → 746
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam01590
    Location:91 → 234
    GAF; GAF domain

  7. XM_028846990.1 → XP_028702823.1  cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X5

    UniProtKB/TrEMBL
    A0A5F8AUT3
    Related
    ENSMMUP00000080756.1, ENSMMUT00000102153.1
    Conserved Domains (3) summary
    smart00065
    Location:277 → 432
    GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
    pfam00233
    Location:524 → 756
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam01590
    Location:101 → 244
    GAF; GAF domain

  8. XM_015137652.2 → XP_014993138.1  cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X4

    UniProtKB/TrEMBL
    G7MR66
    Conserved Domains (3) summary
    smart00065
    Location:267 → 422
    GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
    pfam00233
    Location:514 → 746
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam01590
    Location:91 → 234
    GAF; GAF domain

  9. XM_015137655.2 → XP_014993141.1  cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X6

    UniProtKB/TrEMBL
    A0A1D5Q6B3, G7MR66
    Related
    ENSMMUP00000043579.1, ENSMMUT00000071718.2
    Conserved Domains (3) summary
    smart00065
    Location:260 → 415
    GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
    pfam00233
    Location:507 → 739
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam01590
    Location:84 → 227
    GAF; GAF domain

  10. XM_015137653.2 → XP_014993139.1  cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X4

    UniProtKB/TrEMBL
    G7MR66
    Conserved Domains (3) summary
    smart00065
    Location:267 → 422
    GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
    pfam00233
    Location:514 → 746
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam01590
    Location:91 → 234
    GAF; GAF domain

  11. XM_028846992.1 → XP_028702825.1  cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X7

    UniProtKB/TrEMBL
    A0A5F7ZVN1
    Conserved Domains (3) summary
    smart00065
    Location:197 → 352
    GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
    pfam00233
    Location:444 → 676
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam01590
    Location:21 → 164
    GAF; GAF domain

  12. XM_001105004.4 → XP_001105004.2  cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X7

    UniProtKB/TrEMBL
    A0A5F7ZVN1
    Related
    ENSMMUP00000069714.1, ENSMMUT00000104862.1
    Conserved Domains (3) summary
    smart00065
    Location:197 → 352
    GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
    pfam00233
    Location:444 → 676
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam01590
    Location:21 → 164
    GAF; GAF domain
Nucleotide Protein
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