POU5F1 POU class 5 homeobox 1 [Macaca mulatta (Rhesus monkey)] - Gene

Summary

Gene symbol: POU5F1
Gene description: POU class 5 homeobox 1
See related: Ensembl:ENSMMUG00000015688
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Macaca mulatta
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Also known as: OCT3; OCT4; Oct-4; OCT3/4
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 4

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
103	current	Mmul_10 (GCF_003339765.1)	4	NC_041757.1 (138762445..138768342)
102	previous assembly	Mmul_8.0.1 (GCF_000772875.2)	4	NC_027896.1 (31849068..31854980, complement)

Chromosome 4 - NC_041757.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cytoplasmic CD44 and absence of nuclear Oct3/4 suggest that the cells of cardiac sarcomas may represent 'daughter' stem cells that no longer have the capacity for tumour initiation, but have subsequently developed new lines of partial differentiation.
Title: Primary cardiac sarcomas may develop from resident or bone marrow-derived mesenchymal stem cells: use of immunohistochemistry including CD44 and octamer binding protein 3/4.
Lack of restricted OCT4 protein, and inner cell mass localization of NANOG in primate blastocysts, suggests that NANOG may determine inner cell mass fate more specifically during primate development.
Title: Inner cell mass localization of NANOG precedes OCT3/4 in rhesus monkey blastocysts.

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General gene information

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Markers

GDB:191805 (e-PCR)
- UniSTS:155653

SHGC-12693 (e-PCR)
- UniSTS:38468

POU5F1 (e-PCR)
- UniSTS:479943

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: POU domain, class 5, transcription factor 1

Names: OTF-3; oct-3; octamer-binding protein 3; octamer-binding protein 4; octamer-binding transcription factor 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001114955.1 → NP_001108427.1 POU domain, class 5, transcription factor 1

See identical proteins and their annotated locations for NP_001108427.1

Status: PROVISIONAL

Source sequence(s)

AB128049

UniProtKB/Swiss-Prot

Q5TM49

Related

ENSMMUP00000020597.3, ENSMMUT00000022019.4

Conserved Domains (2) summary

smart00352
Location:138 → 212

POU; Found in Pit-Oct-Unc transcription factors

pfam00046
Location:233 → 286

Homeobox; Homeobox domain