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PTPN6 protein tyrosine phosphatase non-receptor type 6 [ Macaca mulatta (Rhesus monkey) ]

Gene ID: 714374, updated on 17-Aug-2024

Summary

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Official Symbol
PTPN6provided by VGNC
Official Full Name
protein tyrosine phosphatase non-receptor type 6provided by VGNC
Primary source
VGNC:VGNC:76607
See related
Ensembl:ENSMMUG00000010203
Gene type
protein coding
RefSeq status
MODEL
Organism
Macaca mulatta
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs
human mouse all
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Genomic context

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See PTPN6 in Genome Data Viewer
Location:
chromosome: 11
Exon count:
17
Annotation release Status Assembly Chr Location
103 current Mmul_10 (GCF_003339765.1) 11 NC_041764.1 (7117057..7134692)
102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 11 NC_027903.1 (7261310..7278114)

Chromosome 11 - NC_041764.1Genomic Context describing neighboring genes Neighboring gene U7 small nuclear RNA Neighboring gene chromosome 11 C12orf57 homolog Neighboring gene uncharacterized LOC107000739 Neighboring gene microRNA mir-200c Neighboring gene microRNA mir-141

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
tyrosine-protein phosphatase non-receptor type 6
XP_015006430.1
XP_015006431.1
XP_015006432.1
XP_015006433.1
XP_015006435.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

  1. NC_041764.1 Reference Mmul_10 Primary Assembly

    Range
    7117057..7134692
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015150945.2 → XP_015006431.1  tyrosine-protein phosphatase non-receptor type 6 isoform X1

    UniProtKB/TrEMBL
    A0A5K1UTD3, H9F6Y5
    Conserved Domains (4) summary
    cd09931
    Location:140 → 246
    SH2_C-SH2_SHP_like; C-terminal Src homology 2 (C-SH2) domain found in SH2 domain Phosphatases (SHP) proteins
    cd10340
    Location:34 → 132
    SH2_N-SH2_SHP_like; N-terminal Src homology 2 (N-SH2) domain found in SH2 domain Phosphatases (SHP) proteins
    smart00194
    Location:274 → 545
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:303 → 545
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

  2. XM_015150946.2 → XP_015006432.1  tyrosine-protein phosphatase non-receptor type 6 isoform X1

    UniProtKB/TrEMBL
    A0A5K1UTD3, H9F6Y5
    Conserved Domains (4) summary
    cd09931
    Location:140 → 246
    SH2_C-SH2_SHP_like; C-terminal Src homology 2 (C-SH2) domain found in SH2 domain Phosphatases (SHP) proteins
    cd10340
    Location:34 → 132
    SH2_N-SH2_SHP_like; N-terminal Src homology 2 (N-SH2) domain found in SH2 domain Phosphatases (SHP) proteins
    smart00194
    Location:274 → 545
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:303 → 545
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

  3. XM_015150944.2 → XP_015006430.1  tyrosine-protein phosphatase non-receptor type 6 isoform X1

    UniProtKB/TrEMBL
    A0A5K1UTD3, H9F6Y5
    Related
    ENSMMUP00000013344.4, ENSMMUT00000014247.4
    Conserved Domains (4) summary
    cd09931
    Location:140 → 246
    SH2_C-SH2_SHP_like; C-terminal Src homology 2 (C-SH2) domain found in SH2 domain Phosphatases (SHP) proteins
    cd10340
    Location:34 → 132
    SH2_N-SH2_SHP_like; N-terminal Src homology 2 (N-SH2) domain found in SH2 domain Phosphatases (SHP) proteins
    smart00194
    Location:274 → 545
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:303 → 545
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

  4. XM_015150947.2 → XP_015006433.1  tyrosine-protein phosphatase non-receptor type 6 isoform X2

    UniProtKB/TrEMBL
    H9F6Y5
    Related
    ENSMMUP00000061003.2, ENSMMUT00000076803.2
    Conserved Domains (3) summary
    cd09931
    Location:111 → 217
    SH2_C-SH2_SHP_like; C-terminal Src homology 2 (C-SH2) domain found in SH2 domain Phosphatases (SHP) proteins
    cd10340
    Location:6 → 103
    SH2_N-SH2_SHP_like; N-terminal Src homology 2 (N-SH2) domain found in SH2 domain Phosphatases (SHP) proteins
    cd00047
    Location:274 → 516
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

  5. XM_015150949.2 → XP_015006435.1  tyrosine-protein phosphatase non-receptor type 6 isoform X3

    UniProtKB/TrEMBL
    F6SIM1, F6SIN0, H9F6Y5, I0FMS6
    Related
    ENSMMUP00000013343.4, ENSMMUT00000014246.4
    Conserved Domains (3) summary
    cd09931
    Location:109 → 215
    SH2_C-SH2_SHP_like; C-terminal Src homology 2 (C-SH2) domain found in SH2 domain Phosphatases (SHP) proteins
    cd10340
    Location:3 → 101
    SH2_N-SH2_SHP_like; N-terminal Src homology 2 (N-SH2) domain found in SH2 domain Phosphatases (SHP) proteins
    cd00047
    Location:272 → 514
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
Nucleotide Protein
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