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NF1 neurofibromin 1 [ Macaca mulatta (Rhesus monkey) ]

Gene ID: 712911, updated on 17-Aug-2024

Summary

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Official Symbol
NF1provided by VGNC
Official Full Name
neurofibromin 1provided by VGNC
Primary source
VGNC:VGNC:75323
See related
Ensembl:ENSMMUG00000008605
Gene type
protein coding
RefSeq status
MODEL
Organism
Macaca mulatta
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs
human mouse all
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Genomic context

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See NF1 in Genome Data Viewer
Location:
chromosome: 16
Exon count:
59
Annotation release Status Assembly Chr Location
103 current Mmul_10 (GCF_003339765.1) 16 NC_041769.1 (27328260..27627300)
102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 16 NC_027908.1 (25174651..25465379)

Chromosome 16 - NC_041769.1Genomic Context describing neighboring genes Neighboring gene TBC1 domain family member 3B-like Neighboring gene uncharacterized LOC100430885 Neighboring gene ecotropic viral integration site 2B Neighboring gene oligodendrocyte myelin glycoprotein Neighboring gene ecotropic viral integration site 2A Neighboring gene RAB11 family interacting protein 4 Neighboring gene uncharacterized LOC106993951

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Process Evidence Code Pubs
involved_in regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
neurofibromin

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

  1. NC_041769.1 Reference Mmul_10 Primary Assembly

    Range
    27328260..27627300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015119005.2 → XP_014974491.1  neurofibromin isoform X2

    UniProtKB/TrEMBL
    A0A5F8A6Y6, H9ENQ9
    Related
    ENSMMUP00000046085.2, ENSMMUT00000066456.2
    Conserved Domains (3) summary
    cd05130
    Location:1198 → 1551
    RasGAP_Neurofibromin; Ras-GTPase Activating Domain of neurofibromin
    cd13313
    Location:1728 → 1837
    PH_NF1; Neurofibromin-1 Pleckstrin homology-like domain
    pfam13716
    Location:1602 → 1724
    CRAL_TRIO_2; Divergent CRAL/TRIO domain

  2. XM_015119007.2 → XP_014974493.1  neurofibromin isoform X5

    UniProtKB/TrEMBL
    A0A1D5R1N6, H9ENR0
    Conserved Domains (3) summary
    cd05130
    Location:1198 → 1530
    RasGAP_Neurofibromin; Ras-GTPase Activating Domain of neurofibromin
    cd13313
    Location:1707 → 1816
    PH_NF1; Neurofibromin-1 Pleckstrin homology-like domain
    pfam13716
    Location:1581 → 1703
    CRAL_TRIO_2; Divergent CRAL/TRIO domain

  3. XM_015119003.2 → XP_014974489.1  neurofibromin isoform X1

    UniProtKB/TrEMBL
    F7GZA8
    Related
    ENSMMUP00000008965.4, ENSMMUT00000009540.4
    Conserved Domains (4) summary
    cd05130
    Location:1208 → 1561
    RasGAP_Neurofibromin; Ras-GTPase Activating Domain of neurofibromin
    smart00323
    Location:1197 → 1567
    RasGAP; GTPase-activator protein for Ras-like GTPases
    cd13313
    Location:1738 → 1847
    PH_NF1; Neurofibromin-1 Pleckstrin homology-like domain
    pfam13716
    Location:1612 → 1738
    CRAL_TRIO_2; Divergent CRAL/TRIO domain

  4. XM_028836184.1 → XP_028692017.1  neurofibromin isoform X4

    UniProtKB/TrEMBL
    F7GZA8
    Conserved Domains (3) summary
    cd05130
    Location:1208 → 1538
    RasGAP_Neurofibromin; Ras-GTPase Activating Domain of neurofibromin
    cd13313
    Location:1715 → 1824
    PH_NF1; Neurofibromin-1 Pleckstrin homology-like domain
    pfam13716
    Location:1589 → 1714
    CRAL_TRIO_2; Divergent CRAL/TRIO domain

  5. XM_028836183.1 → XP_028692016.1  neurofibromin isoform X3

    UniProtKB/TrEMBL
    A0A1D5R1N6
    Related
    ENSMMUP00000054220.2, ENSMMUT00000067534.2
    Conserved Domains (3) summary
    cd05130
    Location:1208 → 1540
    RasGAP_Neurofibromin; Ras-GTPase Activating Domain of neurofibromin
    cd13313
    Location:1717 → 1826
    PH_NF1; Neurofibromin-1 Pleckstrin homology-like domain
    pfam13716
    Location:1591 → 1716
    CRAL_TRIO_2; Divergent CRAL/TRIO domain
Nucleotide Protein
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