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ACE2 angiotensin converting enzyme 2 [ Macaca mulatta (Rhesus monkey) ]

Gene ID: 712790, updated on 17-Aug-2024

Summary

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Official Symbol
ACE2provided by VGNC
Official Full Name
angiotensin converting enzyme 2provided by VGNC
Primary source
VGNC:VGNC:78431
See related
Ensembl:ENSMMUG00000014048
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Macaca mulatta
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs
human mouse all
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Genomic context

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See ACE2 in Genome Data Viewer
Location:
chromosome: X
Exon count:
19
Annotation release Status Assembly Chr Location
103 current Mmul_10 (GCF_003339765.1) X NC_041774.1 (15247646..15300547, complement)
102 previous assembly Mmul_8.0.1 (GCF_000772875.2) X NC_027913.1 (14865010..14918401, complement)

Chromosome X - NC_041774.1Genomic Context describing neighboring genes Neighboring gene pirin Neighboring gene BMX non-receptor tyrosine kinase Neighboring gene prothymosin alpha-like Neighboring gene collectrin, amino acid transport regulator Neighboring gene putative inactive carbonic anhydrase 5B-like protein Neighboring gene small nucleolar RNA SNORA7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Rhesus angiotensin converting enzyme 2 supports entry of severe acute respiratory syndrome coronavirus in Chinese macaques. Chen Y, et al. Virology, 2008 Nov 10. PMID 18801550, Free PMC Article
  2. Cross-neutralization of SARS-CoV-2 by a human monoclonal SARS-CoV antibody. Pinto D, et al. Nature, 2020 Jul. PMID 32422645
  3. Broad and Differential Animal Angiotensin-Converting Enzyme 2 Receptor Usage by SARS-CoV-2. Zhao X, et al. J Virol, 2020 Aug 31. PMID 32661139, Free PMC Article
  4. Artificial Lipid Biomembranes for Full-Length SARS-CoV-2 Receptor. Wang T, et al. Adv Mater, 2023 Jun. PMID 36932971
  5. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. sporadic non-synonymous substitutions reduced the level of rh-ACE2 protein expression and did not support severe acute respiratory syndrome coronavirus entry effectively
    Title: Rhesus angiotensin converting enzyme 2 supports entry of severe acute respiratory syndrome coronavirus in Chinese macaques.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables peptidyl-dipeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
angiotensin-converting enzyme 2
Names
angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
angiotensin I converting enzyme 2
NP_001129168.1
XP_014982444.2
XP_028697658.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135696.1 → NP_001129168.1  angiotensin-converting enzyme 2 precursor

    See identical proteins and their annotated locations for NP_001129168.1

    Status: PROVISIONAL

    Source sequence(s)
    FJ170101
    UniProtKB/TrEMBL
    B6DUE5, B6DUG6
    Related
    ENSMMUP00000076885.1, ENSMMUT00000105351.1
    Conserved Domains (2) summary
    pfam01401
    Location:19 → 606
    Peptidase_M2; Angiotensin-converting enzyme
    pfam16959
    Location:617 → 770
    Collectrin; Renal amino acid transporter

RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

  1. NC_041774.1 Reference Mmul_10 Primary Assembly

    Range
    15247646..15300547 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_028841825.1 → XP_028697658.1  angiotensin-converting enzyme 2 isoform X1

    UniProtKB/TrEMBL
    B6DUE3, B6DUE5, B6DUE9, B6DUF3, F7AH40, G7NSA6
    Conserved Domains (2) summary
    pfam01401
    Location:19 → 606
    Peptidase_M2; Angiotensin-converting enzyme
    pfam16959
    Location:617 → 770
    Collectrin; Renal amino acid transporter

  2. XM_015126958.2 → XP_014982444.2  angiotensin-converting enzyme 2 isoform X1

    UniProtKB/TrEMBL
    B6DUE3, B6DUE5, B6DUE9, B6DUF3, F7AH40, G7NSA6
    Related
    ENSMMUP00000018465.4, ENSMMUT00000019723.4
    Conserved Domains (2) summary
    pfam01401
    Location:19 → 606
    Peptidase_M2; Angiotensin-converting enzyme
    pfam16959
    Location:617 → 770
    Collectrin; Renal amino acid transporter
Nucleotide Protein
Heading Accession and Version

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