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ARHGEF12 Rho guanine nucleotide exchange factor 12 [ Macaca mulatta (Rhesus monkey) ]

Gene ID: 712096, updated on 17-Aug-2024

Summary

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Official Symbol
ARHGEF12provided by VGNC
Official Full Name
Rho guanine nucleotide exchange factor 12provided by VGNC
Primary source
VGNC:VGNC:99547
See related
Ensembl:ENSMMUG00000012254
Gene type
protein coding
RefSeq status
MODEL
Organism
Macaca mulatta
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs
human mouse all
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Genomic context

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See ARHGEF12 in Genome Data Viewer
Location:
chromosome: 14
Exon count:
45
Annotation release Status Assembly Chr Location
103 current Mmul_10 (GCF_003339765.1) 14 NC_041767.1 (113406660..113555066)
102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 14 NC_027906.1 (113196972..113345816)

Chromosome 14 - NC_041767.1Genomic Context describing neighboring genes Neighboring gene POU class 2 homeobox 3 Neighboring gene TLC domain containing 5 Neighboring gene glutamate ionotropic receptor kainate type subunit 4 Neighboring gene elongin-C pseudogene Neighboring gene tubulin folding cofactor E like Neighboring gene tectorin alpha

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Form deprivation modulates retinal neurogenesis in primate experimental myopia. Tkatchenko AV, et al. Proc Natl Acad Sci U S A, 2006 Mar 21. PMID 16537371, Free PMC Article
  2. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
  3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables G protein-coupled receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in Rho protein signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
rho guanine nucleotide exchange factor 12

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

  1. NC_041767.1 Reference Mmul_10 Primary Assembly

    Range
    113406660..113555066
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015115967.2 → XP_014971453.1  rho guanine nucleotide exchange factor 12 isoform X4

    UniProtKB/TrEMBL
    F6UZH5, I2CT39
    Related
    ENSMMUP00000016088.4, ENSMMUT00000017178.4
    Conserved Domains (4) summary
    cd08754
    Location:330 → 551
    RGS_LARG; Regulator of G protein signaling (RGS) domain found in the leukemia-associated Rho guanine nucleotide exchange factor (RhoGEF) protein (LARG)
    cd00992
    Location:52 → 126
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13390
    Location:976 → 1113
    PH_LARG; Leukemia-associated Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
    pfam00621
    Location:772 → 957
    RhoGEF; RhoGEF domain

  2. XM_015115966.2 → XP_014971452.1  rho guanine nucleotide exchange factor 12 isoform X2

    UniProtKB/TrEMBL
    A0A1D5R2Y9, I2CT39
    Related
    ENSMMUP00000054674.2, ENSMMUT00000060790.2
    Conserved Domains (4) summary
    cd08754
    Location:349 → 570
    RGS_LARG; Regulator of G protein signaling (RGS) domain found in the leukemia-associated Rho guanine nucleotide exchange factor (RhoGEF) protein (LARG)
    cd00992
    Location:71 → 145
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13390
    Location:995 → 1132
    PH_LARG; Leukemia-associated Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
    pfam00621
    Location:791 → 976
    RhoGEF; RhoGEF domain

  3. XM_015115970.2 → XP_014971456.1  rho guanine nucleotide exchange factor 12 isoform X7

    UniProtKB/TrEMBL
    H9F7A3
    Conserved Domains (4) summary
    cd08754
    Location:246 → 467
    RGS_LARG; Regulator of G protein signaling (RGS) domain found in the leukemia-associated Rho guanine nucleotide exchange factor (RhoGEF) protein (LARG)
    cd00992
    Location:2 → 42
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13390
    Location:892 → 1029
    PH_LARG; Leukemia-associated Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
    pfam00621
    Location:688 → 873
    RhoGEF; RhoGEF domain

  4. XM_028834080.1 → XP_028689913.1  rho guanine nucleotide exchange factor 12 isoform X6

    UniProtKB/TrEMBL
    A0A5F8ARW5, H9F7A3
    Conserved Domains (4) summary
    cd08754
    Location:287 → 508
    RGS_LARG; Regulator of G protein signaling (RGS) domain found in the leukemia-associated Rho guanine nucleotide exchange factor (RhoGEF) protein (LARG)
    smart00325
    Location:729 → 914
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd00992
    Location:9 → 83
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13390
    Location:933 → 1070
    PH_LARG; Leukemia-associated Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain

  5. XM_015115969.2 → XP_014971455.1  rho guanine nucleotide exchange factor 12 isoform X6

    UniProtKB/TrEMBL
    A0A5F8ARW5, H9F7A3
    Related
    ENSMMUP00000080695.1, ENSMMUT00000101585.1
    Conserved Domains (4) summary
    cd08754
    Location:287 → 508
    RGS_LARG; Regulator of G protein signaling (RGS) domain found in the leukemia-associated Rho guanine nucleotide exchange factor (RhoGEF) protein (LARG)
    smart00325
    Location:729 → 914
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd00992
    Location:9 → 83
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13390
    Location:933 → 1070
    PH_LARG; Leukemia-associated Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain

  6. XM_028834079.1 → XP_028689912.1  rho guanine nucleotide exchange factor 12 isoform X5

    UniProtKB/TrEMBL
    A0A1D5RKM0
    Conserved Domains (4) summary
    cd08754
    Location:313 → 534
    RGS_LARG; Regulator of G protein signaling (RGS) domain found in the leukemia-associated Rho guanine nucleotide exchange factor (RhoGEF) protein (LARG)
    smart00325
    Location:755 → 940
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd00992
    Location:75 → 149
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13390
    Location:959 → 1096
    PH_LARG; Leukemia-associated Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain

  7. XM_028834077.1 → XP_028689910.1  rho guanine nucleotide exchange factor 12 isoform X1

    UniProtKB/TrEMBL
    H9F7A3
    Related
    ENSMMUP00000044671.2, ENSMMUT00000054597.2
    Conserved Domains (4) summary
    cd08754
    Location:353 → 574
    RGS_LARG; Regulator of G protein signaling (RGS) domain found in the leukemia-associated Rho guanine nucleotide exchange factor (RhoGEF) protein (LARG)
    smart00325
    Location:795 → 980
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd00992
    Location:75 → 149
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13390
    Location:999 → 1136
    PH_LARG; Leukemia-associated Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain

  8. XM_028834078.1 → XP_028689911.1  rho guanine nucleotide exchange factor 12 isoform X3

    UniProtKB/TrEMBL
    H9F7A3
    Conserved Domains (4) summary
    cd08754
    Location:334 → 555
    RGS_LARG; Regulator of G protein signaling (RGS) domain found in the leukemia-associated Rho guanine nucleotide exchange factor (RhoGEF) protein (LARG)
    smart00325
    Location:776 → 961
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd00992
    Location:56 → 130
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13390
    Location:980 → 1117
    PH_LARG; Leukemia-associated Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
Nucleotide Protein
Heading Accession and Version

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