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RAPGEF5 Rap guanine nucleotide exchange factor 5 [ Macaca mulatta (Rhesus monkey) ]

Gene ID: 711698, updated on 17-Aug-2024

Summary

Official Symbol
RAPGEF5provided by VGNC
Official Full Name
Rap guanine nucleotide exchange factor 5provided by VGNC
Primary source
VGNC:VGNC:76494
See related
Ensembl:ENSMMUG00000002987
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Macaca mulatta
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs
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Genomic context

See RAPGEF5 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
27
Annotation release Status Assembly Chr Location
103 current Mmul_10 (GCF_003339765.1) 3 NC_041756.1 (92693594..92936892)
102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 3 NC_027895.1 (85867163..86111414)

Chromosome 3 - NC_041756.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC114676967 Neighboring gene uncharacterized LOC106997496 Neighboring gene uncharacterized LOC114676968 Neighboring gene cell division cycle associated 7 like Neighboring gene dynein axonemal heavy chain 11

Genomic regions, transcripts, and products

General gene information

Markers

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
PubMed 
Process Evidence Code Pubs
involved_in Ras protein signal transduction IEA
Inferred from Electronic Annotation
more info
PubMed 
involved_in positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
PubMed 

General protein information

Preferred Names
rap guanine nucleotide exchange factor 5
Names
Rap guanine nucleotide exchange factor (GEF) 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001194158.3NP_001181087.1  rap guanine nucleotide exchange factor 5

    See identical proteins and their annotated locations for NP_001181087.1

    Status: PROVISIONAL

    Source sequence(s)
    QNVO02000313
    UniProtKB/TrEMBL
    A0A1D5Q995, H9G2F6
    Related
    ENSMMUP00000044613.2, ENSMMUT00000068824.2
    Conserved Domains (3) summary
    smart00147
    Location:491730
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:219350
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cl02442
    Location:172
    DEP; DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first discovered. The function of this domain is still not clear, but it is believed to be important for the membrane association of the signaling proteins in which it is ...

RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

  1. NC_041756.1 Reference Mmul_10 Primary Assembly

    Range
    92693594..92936892
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015133876.2XP_014989362.2  rap guanine nucleotide exchange factor 5 isoform X1

    UniProtKB/TrEMBL
    F6WAW0, F7GVW4
    Related
    ENSMMUP00000035150.3, ENSMMUT00000042151.3
    Conserved Domains (3) summary
    smart00147
    Location:644883
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:372503
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd04437
    Location:103225
    DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
  2. XM_028844993.1XP_028700826.1  rap guanine nucleotide exchange factor 5 isoform X3

    UniProtKB/TrEMBL
    F7GVW4
    Conserved Domains (3) summary
    smart00147
    Location:547786
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:275406
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cl02442
    Location:103130
    DEP; DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first discovered. The function of this domain is still not clear, but it is believed to be important for the membrane association of the signaling proteins in which it is ...
  3. XM_028844992.1XP_028700825.1  rap guanine nucleotide exchange factor 5 isoform X2

    UniProtKB/TrEMBL
    F7GVX4
    Related
    ENSMMUP00000003993.4, ENSMMUT00000004233.4
    Conserved Domains (3) summary
    smart00147
    Location:594833
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:322453
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd04437
    Location:53175
    DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...