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PRKN parkin RBR E3 ubiquitin protein ligase [ Macaca mulatta (Rhesus monkey) ]

Gene ID: 710899, updated on 17-Aug-2024

Summary

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Official Symbol
PRKNprovided by VGNC
Official Full Name
parkin RBR E3 ubiquitin protein ligaseprovided by VGNC
Primary source
VGNC:VGNC:76364
See related
Ensembl:ENSMMUG00000020410
Gene type
protein coding
RefSeq status
MODEL
Organism
Macaca mulatta
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Also known as
PARK2
Orthologs
human mouse all
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Genomic context

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See PRKN in Genome Data Viewer
Location:
chromosome: 4
Exon count:
13
Annotation release Status Assembly Chr Location
103 current Mmul_10 (GCF_003339765.1) 4 NC_041757.1 (8030146..9397207)
102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 4 NC_027896.1 (162407409..163806999, complement)

Chromosome 4 - NC_041757.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA U13 Neighboring gene parkin coregulated Neighboring gene 60S ribosomal protein L34 pseudogene Neighboring gene uncharacterized LOC106998111 Neighboring gene keratin, type II cytoskeletal 8 pseudogene Neighboring gene uncharacterized LOC114677763 Neighboring gene uncharacterized LOC114677762 Neighboring gene 60S ribosomal protein L6 pseudogene Neighboring gene uncharacterized LOC106998112 Neighboring gene uncharacterized LOC114677451 Neighboring gene 1-acylglycerol-3-phosphate O-acyltransferase 4 Neighboring gene mitogen-activated protein kinase kinase kinase 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ubiquitin conjugating enzyme binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in autophagy of mitochondrion IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein polyubiquitination IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of cellular response to oxidative stress IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of mitochondrion organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of ubiquitin ligase complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
E3 ubiquitin-protein ligase parkin

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

  1. NC_041757.1 Reference Mmul_10 Primary Assembly

    Range
    8030146..9397207
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015137330.2 → XP_014992816.2  E3 ubiquitin-protein ligase parkin isoform X1

    UniProtKB/TrEMBL
    F6U1L3, G7MR09
    Related
    ENSMMUP00000026859.4, ENSMMUT00000028706.4
    Conserved Domains (4) summary
    smart00647
    Location:313 → 375
    IBR; In Between Ring fingers
    pfam01485
    Location:413 → 453
    IBR; IBR domain, a half RING-finger domain
    cd16627
    Location:236 → 294
    RING-HC_RBR_parkin; RING finger, HC subclass, found in parkin and similar proteins
    cd01798
    Location:3 → 76
    Ubl_parkin; ubiquitin-like (Ubl) domain found in parkin and similar proteins

  2. XM_015137332.2 → XP_014992818.2  E3 ubiquitin-protein ligase parkin isoform X3

    UniProtKB/TrEMBL
    G7MR09
    Conserved Domains (3) summary
    smart00647
    Location:313 → 375
    IBR; In Between Ring fingers
    cd16627
    Location:236 → 294
    RING-HC_RBR_parkin; RING finger, HC subclass, found in parkin and similar proteins
    cd01798
    Location:3 → 76
    Ubl_parkin; ubiquitin-like (Ubl) domain found in parkin and similar proteins

  3. XM_015137331.2 → XP_014992817.2  E3 ubiquitin-protein ligase parkin isoform X2

    UniProtKB/TrEMBL
    G7MR09
    Conserved Domains (4) summary
    smart00647
    Location:312 → 374
    IBR; In Between Ring fingers
    pfam01485
    Location:412 → 452
    IBR; IBR domain, a half RING-finger domain
    cd16627
    Location:235 → 293
    RING-HC_RBR_parkin; RING finger, HC subclass, found in parkin and similar proteins
    cd01798
    Location:3 → 76
    Ubl_parkin; ubiquitin-like (Ubl) domain found in parkin and similar proteins

  4. XM_028847918.1 → XP_028703751.1  E3 ubiquitin-protein ligase parkin isoform X4

    UniProtKB/TrEMBL
    G7MR09
    Conserved Domains (2) summary
    pfam01485
    Location:234 → 296
    IBR; IBR domain, a half RING-finger domain
    cd16627
    Location:157 → 215
    RING-HC_RBR_parkin; RING finger, HC subclass, found in parkin and similar proteins
Nucleotide Protein
Heading Accession and Version

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