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NFKB1 nuclear factor kappa B subunit 1 [ Macaca mulatta (Rhesus monkey) ]

Gene ID: 710324, updated on 17-Aug-2024

Summary

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Official Symbol
NFKB1provided by VGNC
Official Full Name
nuclear factor kappa B subunit 1provided by VGNC
Primary source
VGNC:VGNC:75339
Locus tag
EGK_15972
See related
Ensembl:ENSMMUG00000003736
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Macaca mulatta
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs
human mouse all
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Genomic context

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See NFKB1 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
28
Annotation release Status Assembly Chr Location
103 current Mmul_10 (GCF_003339765.1) 5 NC_041758.1 (100887542..101010961)
102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 5 NC_027897.1 (101330818..101454505)

Chromosome 5 - NC_041758.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 39 member 8 Neighboring gene zinc finger protein 705A pseudogene Neighboring gene protein argonaute 14 Neighboring gene uncharacterized LOC114678365 Neighboring gene 60S ribosomal protein L17 pseudogene Neighboring gene mannosidase beta Neighboring gene protein MANBAL pseudogene Neighboring gene 40S ribosomal protein S29 pseudogene Neighboring gene keratin, type II cytoskeletal 8 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Rhesus monkey TRIM5α represses HIV-1 LTR promoter activity by negatively regulating TAK1/TAB1/TAB2/TAB3-complex-mediated NF-κB activation. Gong J, et al. Arch Virol, 2011 Nov. PMID 21918865
  2. Genome sequencing and comparison of two nonhuman primate animal models, the cynomolgus and Chinese rhesus macaques. Yan G, et al. Nat Biotechnol, 2011 Oct 16. PMID 22002653
  3. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
  4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TRIM5alpha represses HIV-1 LTR promoter activity by negatively regulating TAK1/TAB1/TAB2/TAB3-complex-mediated NF-kappaB activation.
    Title: Rhesus monkey TRIM5α represses HIV-1 LTR promoter activity by negatively regulating TAK1/TAB1/TAB2/TAB3-complex-mediated NF-κB activation.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in canonical NF-kappaB signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cellular response to stress IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in inflammatory response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in non-canonical NF-kappaB signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in response to cytokine IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
nuclear factor NF-kappa-B p105 subunit
Names
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001266053.1 → NP_001252982.1  nuclear factor NF-kappa-B p105 subunit

    See identical proteins and their annotated locations for NP_001252982.1

    Status: PROVISIONAL

    Source sequence(s)
    JV043229
    UniProtKB/TrEMBL
    A0A8J8Y2C4, F6S0D1, G7MTI9, H9Z1D5
    Related
    ENSMMUP00000004986.3, ENSMMUT00000005292.4
    Conserved Domains (7) summary
    cd07935
    Location:43 → 244
    RHD-n_NFkB1; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of kappa B1 (NF-kappa B1)
    COG0666
    Location:484 → 706
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd01177
    Location:251 → 352
    IPT_NFkappaB; IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to ...
    cd08797
    Location:816 → 891
    Death_NFkB1_p105; Death domain of the Nuclear Factor-KappaB1 precursor protein p105
    sd00045
    Location:543 → 580
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:587 → 681
    Ank_2; Ankyrin repeats (3 copies)
    cl39094
    Location:690 → 733
    Ank_2; Ankyrin repeats (3 copies)

RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

  1. NC_041758.1 Reference Mmul_10 Primary Assembly

    Range
    100887542..101010961
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015138835.2 → XP_014994321.1  nuclear factor NF-kappa-B p105 subunit isoform X3

    UniProtKB/TrEMBL
    H9Z1D5, I2CVP9
    Conserved Domains (7) summary
    cd07935
    Location:42 → 243
    RHD-n_NFkB1; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of kappa B1 (NF-kappa B1)
    COG0666
    Location:483 → 705
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd01177
    Location:250 → 351
    IPT_NFkappaB; IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to ...
    cd08797
    Location:815 → 890
    Death_NFkB1_p105; Death domain of the Nuclear Factor-KappaB1 precursor protein p105
    sd00045
    Location:542 → 579
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:586 → 680
    Ank_2; Ankyrin repeats (3 copies)
    cl39094
    Location:689 → 732
    Ank_2; Ankyrin repeats (3 copies)

  2. XM_028848098.1 → XP_028703931.1  nuclear factor NF-kappa-B p105 subunit isoform X4

    UniProtKB/TrEMBL
    H9Z1D5
    Conserved Domains (7) summary
    COG0666
    Location:352 → 574
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd01177
    Location:119 → 220
    IPT_NFkappaB; IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to ...
    cd08797
    Location:684 → 759
    Death_NFkB1_p105; Death domain of the Nuclear Factor-KappaB1 precursor protein p105
    sd00045
    Location:411 → 448
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:554 → 602
    Ank_4; Ankyrin repeats (many copies)
    pfam12796
    Location:455 → 549
    Ank_2; Ankyrin repeats (3 copies)
    cl08275
    Location:1 → 112
    RHD-n; N-terminal sub-domain of the Rel homology domain (RHD)

  3. XM_015138833.2 → XP_014994319.1  nuclear factor NF-kappa-B p105 subunit isoform X1

    UniProtKB/TrEMBL
    F7HKH9, H9Z1D5
    Related
    ENSMMUP00000034946.3, ENSMMUT00000041936.3
    Conserved Domains (7) summary
    cd07935
    Location:51 → 252
    RHD-n_NFkB1; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of kappa B1 (NF-kappa B1)
    COG0666
    Location:492 → 714
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd01177
    Location:259 → 360
    IPT_NFkappaB; IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to ...
    cd08797
    Location:824 → 899
    Death_NFkB1_p105; Death domain of the Nuclear Factor-KappaB1 precursor protein p105
    sd00045
    Location:551 → 588
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:595 → 689
    Ank_2; Ankyrin repeats (3 copies)
    cl39094
    Location:698 → 741
    Ank_2; Ankyrin repeats (3 copies)

  4. XM_015138834.2 → XP_014994320.1  nuclear factor NF-kappa-B p105 subunit isoform X2

    UniProtKB/TrEMBL
    H9Z1D5
    Conserved Domains (7) summary
    cd07935
    Location:50 → 251
    RHD-n_NFkB1; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of kappa B1 (NF-kappa B1)
    COG0666
    Location:491 → 713
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd01177
    Location:258 → 359
    IPT_NFkappaB; IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to ...
    cd08797
    Location:823 → 898
    Death_NFkB1_p105; Death domain of the Nuclear Factor-KappaB1 precursor protein p105
    sd00045
    Location:550 → 587
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:594 → 688
    Ank_2; Ankyrin repeats (3 copies)
    cl39094
    Location:697 → 740
    Ank_2; Ankyrin repeats (3 copies)

  5. XM_015138836.2 → XP_014994322.1  nuclear factor NF-kappa-B p105 subunit isoform X4

    UniProtKB/TrEMBL
    H9Z1D5
    Conserved Domains (7) summary
    COG0666
    Location:352 → 574
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd01177
    Location:119 → 220
    IPT_NFkappaB; IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to ...
    cd08797
    Location:684 → 759
    Death_NFkB1_p105; Death domain of the Nuclear Factor-KappaB1 precursor protein p105
    sd00045
    Location:411 → 448
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:554 → 602
    Ank_4; Ankyrin repeats (many copies)
    pfam12796
    Location:455 → 549
    Ank_2; Ankyrin repeats (3 copies)
    cl08275
    Location:1 → 112
    RHD-n; N-terminal sub-domain of the Rel homology domain (RHD)

  6. XM_015138837.2 → XP_014994323.1  nuclear factor NF-kappa-B p105 subunit isoform X4

    UniProtKB/TrEMBL
    H9Z1D5
    Conserved Domains (7) summary
    COG0666
    Location:352 → 574
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd01177
    Location:119 → 220
    IPT_NFkappaB; IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to ...
    cd08797
    Location:684 → 759
    Death_NFkB1_p105; Death domain of the Nuclear Factor-KappaB1 precursor protein p105
    sd00045
    Location:411 → 448
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:554 → 602
    Ank_4; Ankyrin repeats (many copies)
    pfam12796
    Location:455 → 549
    Ank_2; Ankyrin repeats (3 copies)
    cl08275
    Location:1 → 112
    RHD-n; N-terminal sub-domain of the Rel homology domain (RHD)

  7. XM_015138838.2 → XP_014994324.1  nuclear factor NF-kappa-B p105 subunit isoform X4

    UniProtKB/TrEMBL
    H9Z1D5
    Conserved Domains (7) summary
    COG0666
    Location:352 → 574
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd01177
    Location:119 → 220
    IPT_NFkappaB; IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to ...
    cd08797
    Location:684 → 759
    Death_NFkB1_p105; Death domain of the Nuclear Factor-KappaB1 precursor protein p105
    sd00045
    Location:411 → 448
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:554 → 602
    Ank_4; Ankyrin repeats (many copies)
    pfam12796
    Location:455 → 549
    Ank_2; Ankyrin repeats (3 copies)
    cl08275
    Location:1 → 112
    RHD-n; N-terminal sub-domain of the Rel homology domain (RHD)

  8. XM_028848099.1 → XP_028703932.1  nuclear factor NF-kappa-B p105 subunit isoform X4

    UniProtKB/TrEMBL
    H9Z1D5
    Conserved Domains (7) summary
    COG0666
    Location:352 → 574
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd01177
    Location:119 → 220
    IPT_NFkappaB; IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to ...
    cd08797
    Location:684 → 759
    Death_NFkB1_p105; Death domain of the Nuclear Factor-KappaB1 precursor protein p105
    sd00045
    Location:411 → 448
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:554 → 602
    Ank_4; Ankyrin repeats (many copies)
    pfam12796
    Location:455 → 549
    Ank_2; Ankyrin repeats (3 copies)
    cl08275
    Location:1 → 112
    RHD-n; N-terminal sub-domain of the Rel homology domain (RHD)
Nucleotide Protein
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