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Prss54 serine protease 54 [ Mus musculus (house mouse) ]

Gene ID: 70993, updated on 27-Nov-2024

Summary

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Official Symbol
Prss54provided by MGI
Official Full Name
serine protease 54provided by MGI
Primary source
MGI:MGI:1918243
See related
Ensembl:ENSMUSG00000048400 AllianceGenome:MGI:1918243
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Klkbl4; 4931432M23Rik
Summary
Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in extracellular region. Orthologous to human PRSS54 (serine protease 54). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward testis adult (RPKM 70.8) See more
Orthologs
human all
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Genomic context

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See Prss54 in Genome Data Viewer
Location:
8 D1; 8 47.12 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (96285694..96302965, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (95559066..95576337, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4933406B17 gene Neighboring gene coiled-coil domain containing 113 Neighboring gene STARR-seq mESC enhancer starr_22390 Neighboring gene G patch domain and KOW motifs pseudogene Neighboring gene STARR-seq mESC enhancer starr_22391 Neighboring gene predicted gene, 31518

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Testis-specific serine protease PRSS54 regulates acrosomal granule localization and sperm head morphogenesis in mice†. Shen C, et al. Biol Reprod, 2022 Oct 11. PMID 35863763
  2. The testis-specific serine proteases PRSS44, PRSS46, and PRSS54 are dispensable for male mouse fertility†. Holcomb RJ, et al. Biol Reprod, 2020 Feb 12. PMID 31403672, Free PMC Article
  3. Human and mouse proteases: a comparative genomic approach. Puente XS, et al. Nat Rev Genet, 2003 Jul. PMID 12838346
  4. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
  5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Testis-specific serine protease PRSS54 regulates acrosomal granule localization and sperm head morphogenesis in micedagger.
    Title: Testis-specific serine protease PRSS54 regulates acrosomal granule localization and sperm head morphogenesis in mice†.
  2. The testis-specific serine proteases PRSS44, PRSS46, and PRSS54 are dispensable for male mouse fertilitydagger.
    Title: The testis-specific serine proteases PRSS44, PRSS46, and PRSS54 are dispensable for male mouse fertility†.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
inactive serine protease 54
Names
plasma kallikrein-like protein 4
protease, serine 54

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310539.1 → NP_001297468.1  inactive serine protease 54

    Status: VALIDATED

    Source sequence(s)
    AC102555, BC145787, BY716181
    Consensus CDS
    CCDS80916.1
    UniProtKB/Swiss-Prot
    Q7M756
    UniProtKB/TrEMBL
    A6H685, B7ZMX6
    Related
    ENSMUSP00000058859.7, ENSMUST00000052690.13
    Conserved Domains (1) summary
    cd00190
    Location:42 → 253
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    96285694..96302965 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006531368.4 → XP_006531431.1  inactive serine protease 54 isoform X2

    UniProtKB/Swiss-Prot
    Q7M756
    UniProtKB/TrEMBL
    A6H685, B7ZMX6
    Conserved Domains (1) summary
    cd00190
    Location:42 → 253
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  2. XM_017312965.2 → XP_017168454.1  inactive serine protease 54 isoform X2

    UniProtKB/Swiss-Prot
    Q7M756
    UniProtKB/TrEMBL
    A6H685, B7ZMX6
    Conserved Domains (1) summary
    cd00190
    Location:42 → 253
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  3. XM_017312964.2 → XP_017168453.1  inactive serine protease 54 isoform X2

    UniProtKB/Swiss-Prot
    Q7M756
    UniProtKB/TrEMBL
    A6H685, B7ZMX6
    Conserved Domains (1) summary
    cd00190
    Location:42 → 253
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  4. XM_006531366.3 → XP_006531429.1  inactive serine protease 54 isoform X2

    UniProtKB/Swiss-Prot
    Q7M756
    UniProtKB/TrEMBL
    A6H685, B7ZMX6
    Conserved Domains (1) summary
    cd00190
    Location:42 → 253
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  5. XM_006531365.3 → XP_006531428.1  inactive serine protease 54 isoform X1

    UniProtKB/Swiss-Prot
    Q7M756
    UniProtKB/TrEMBL
    B7ZMX6
    Conserved Domains (1) summary
    cd00190
    Location:88 → 299
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_027640.1: Suppressed sequence

    Description
    NM_027640.1: This RefSeq has been removed because currently there is insufficient support for the transcript.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7M756.1 GenPept UniProtKB/Swiss-Prot:Q7M756

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