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Nt5c1b 5'-nucleotidase, cytosolic IB [ Mus musculus (house mouse) ]

Gene ID: 70881, updated on 27-Nov-2024

Summary

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Official Symbol
Nt5c1bprovided by MGI
Official Full Name
5'-nucleotidase, cytosolic IBprovided by MGI
Primary source
MGI:MGI:1918131
See related
Ensembl:ENSMUSG00000020622 AllianceGenome:MGI:1918131
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AIRP; cN1B; CN-IB; 4921514H13Rik
Summary
Enables 5'-nucleotidase activity. Involved in AMP catabolic process; allantoin metabolic process; and amide catabolic process. Acts upstream of or within nucleoside metabolic process. Is active in cytosol. Is expressed in several structures, including genitourinary system; gut; and skin. Orthologous to several human genes including NT5C1B (5'-nucleotidase, cytosolic IB). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward testis adult (RPKM 189.3) See more
Orthologs
human all
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Genomic context

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See Nt5c1b in Genome Data Viewer
Location:
12 A1.1; 12 5.27 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (10419971..10440174)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (10369971..10390174)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 46324 Neighboring gene acetyl-Coenzyme A carboxylase alpha pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E5319 Neighboring gene retinol dehydrogenase 14 (all-trans and 9-cis) Neighboring gene predicted gene, 38407 Neighboring gene STARR-seq mESC enhancer starr_31530

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Melatonin receptor deficiency decreases and temporally shifts ecto-5'-nucleotidase mRNA levels in mouse prosencephalon. Homola M, et al. Cell Tissue Res, 2016 Jul. PMID 26917036
  2. Cloning of a mouse cytosolic 5'-nucleotidase-I identifies a new gene related to human autoimmune infertility-related protein. Sala-Newby GB, et al. Biochim Biophys Acta, 2001 Oct 31. PMID 11690631
  3. Gene-deficient mouse model established by CRISPR/Cas9 system reveals 15 reproductive organ-enriched genes dispensable for male fertility. Nguyen TTT, et al. Front Cell Dev Biol, 2024. PMID 38835510, Free PMC Article
  4. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
  5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ecto-5'-nucleotidase mRNA levels were found to be diminished in both MT1 and MT1/2 knockout mice.
    Title: Melatonin receptor deficiency decreases and temporally shifts ecto-5'-nucleotidase mRNA levels in mouse prosencephalon.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2)  1 citation
  • Targeted (3) 

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 5'-nucleotidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 5'-nucleotidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 5'-nucleotidase activity ISO
Inferred from Sequence Orthology
more info
  
enables XMP 5'-nucleosidase activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in AMP catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in adenosine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in adenosine metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in allantoin metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in amide catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within nucleoside metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
cytosolic 5'-nucleotidase 1B
Names
5'nucleotidase
autoimmune infertility-related protein
cytosolic 5'-nucleotidase IB
NP_001297511.1
NP_001360900.1
NP_001360901.1
NP_001360902.1
NP_001360903.1
NP_001360904.1
NP_081864.2
XP_006515274.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310582.1 → NP_001297511.1  cytosolic 5'-nucleotidase 1B isoform 2

    See identical proteins and their annotated locations for NP_001297511.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses two alternate in-frame splice sites in the 5' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC157570, BC060976
    Consensus CDS
    CCDS79106.1
    UniProtKB/TrEMBL
    A0A1W2P7S7, Q6P906
    Related
    ENSMUSP00000112694.2, ENSMUST00000118657.8
    Conserved Domains (1) summary
    pfam06189
    Location:280 → 548
    5-nucleotidase; 5'-nucleotidase

  2. NM_001373971.1 → NP_001360900.1  cytosolic 5'-nucleotidase 1B isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (3).
    Source sequence(s)
    AC157570
    Consensus CDS
    CCDS88310.1
    UniProtKB/TrEMBL
    A0A1W2P6X8
    Related
    ENSMUSP00000151401.2, ENSMUST00000219826.2
    Conserved Domains (1) summary
    pfam06189
    Location:356 → 624
    5-nucleotidase; 5'-nucleotidase

  3. NM_001373972.1 → NP_001360901.1  cytosolic 5'-nucleotidase 1B isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC157570
    Conserved Domains (1) summary
    pfam06189
    Location:354 → 622
    5-nucleotidase; 5'-nucleotidase

  4. NM_001373973.1 → NP_001360902.1  cytosolic 5'-nucleotidase 1B isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC157570
    Consensus CDS
    CCDS88309.1
    UniProtKB/TrEMBL
    A0A1W2P7K9, A0A1W2P7S7
    Related
    ENSMUSP00000151734.2, ENSMUST00000217944.2
    Conserved Domains (1) summary
    pfam06189
    Location:340 → 608
    5-nucleotidase; 5'-nucleotidase

  5. NM_001373974.1 → NP_001360903.1  cytosolic 5'-nucleotidase 1B isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC157570
    Consensus CDS
    CCDS88311.1
    UniProtKB/TrEMBL
    A0A1W2P7E9, A0A1W2P7S7
    Related
    ENSMUSP00000151618.3, ENSMUST00000218339.3
    Conserved Domains (1) summary
    pfam06189
    Location:296 → 564
    5-nucleotidase; 5'-nucleotidase

  6. NM_001373975.1 → NP_001360904.1  cytosolic 5'-nucleotidase 1B isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC157570
    Consensus CDS
    CCDS88312.1
    UniProtKB/TrEMBL
    A0A1W2P7S7, A0A1Y7VK90
    Related
    ENSMUSP00000152838.2, ENSMUST00000223534.2
    Conserved Domains (1) summary
    pfam06189
    Location:282 → 550
    5-nucleotidase; 5'-nucleotidase

  7. NM_027588.3 → NP_081864.2  cytosolic 5'-nucleotidase 1B isoform 1

    See identical proteins and their annotated locations for NP_081864.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AK014892, BB573272
    Consensus CDS
    CCDS25810.1
    UniProtKB/Swiss-Prot
    E9QNH2, Q91Y48, Q91YE9
    UniProtKB/TrEMBL
    A0A1W2P7S7
    Related
    ENSMUSP00000002456.9, ENSMUST00000002456.10
    Conserved Domains (1) summary
    pfam06189
    Location:298 → 566
    5-nucleotidase; 5'-nucleotidase

RNA

  1. NR_164200.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC157570
    Related
    ENSMUST00000219292.2

  2. NR_164201.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC157570
    Related
    ENSMUST00000219049.2

  3. NR_164202.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC157570
    Related
    ENSMUST00000218417.2

  4. NR_164203.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC157570
    Related
    ENSMUST00000218287.2

  5. NR_164204.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC157570
    Related
    ENSMUST00000218551.2

  6. NR_164205.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC157570
    Related
    ENSMUST00000218026.2

  7. NR_164206.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC157570

  8. NR_164207.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC157570
    Related
    ENSMUST00000218327.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    10419971..10440174
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006515211.4 → XP_006515274.1  cytosolic 5'-nucleotidase 1B isoform X1

    UniProtKB/TrEMBL
    A0A1W2P7D6
    Related
    ENSMUSP00000151627.2, ENSMUST00000220257.2
    Conserved Domains (1) summary
    pfam06189
    Location:356 → 376
    5-nucleotidase; 5'-nucleotidase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91YE9.2 GenPept UniProtKB/Swiss-Prot:Q91YE9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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