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TRAF2 TNF receptor associated factor 2 [ Macaca mulatta (Rhesus monkey) ]

Gene ID: 708391, updated on 17-Aug-2024

Summary

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Official Symbol
TRAF2provided by VGNC
Official Full Name
TNF receptor associated factor 2provided by VGNC
Primary source
VGNC:VGNC:78641
See related
Ensembl:ENSMMUG00000011527
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Macaca mulatta
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs
human mouse all
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Genomic context

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See TRAF2 in Genome Data Viewer
Location:
chromosome: 15
Exon count:
14
Annotation release Status Assembly Chr Location
103 current Mmul_10 (GCF_003339765.1) 15 NC_041768.1 (1286874..1332170, complement)
102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 15 NC_027907.1 (1360201..1405808, complement)

Chromosome 15 - NC_041768.1Genomic Context describing neighboring genes Neighboring gene complement C8 gamma chain Neighboring gene F-box and WD repeat domain containing 5 Neighboring gene endothelial differentiation related factor 1 Neighboring gene MAM domain containing 4 Neighboring gene phosphohistidine phosphatase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables tumor necrosis factor receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ubiquitin protein ligase binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ubiquitin-protein transferase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in activation of NF-kappaB-inducing kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of JNK cascade IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of NF-kappaB transcription factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of canonical NF-kappaB signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein K63-linked ubiquitination IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein autoubiquitination IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in tumor necrosis factor-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasmic side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of plasma membrane signaling receptor complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
TNF receptor-associated factor 2
NP_001181721.1
XP_001092078.1
XP_001092203.1
XP_014971792.1
XP_014971794.1
XP_014971795.1
XP_014971796.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001194792.3 → NP_001181721.1  TNF receptor-associated factor 2

    Status: PROVISIONAL

    Source sequence(s)
    QNVO02000131
    UniProtKB/TrEMBL
    H9EUU8
    Conserved Domains (3) summary
    cd03778
    Location:323 → 486
    MATH_TRAF2; Tumor Necrosis Factor Receptor (TNFR) Associated Factor (TRAF) family, TRAF2 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...
    pfam02176
    Location:167 → 224
    zf-TRAF; TRAF-type zinc finger
    pfam16673
    Location:256 → 318
    TRAF_BIRC3_bd; TNF receptor-associated factor BIRC3 binding domain

RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

  1. NC_041768.1 Reference Mmul_10 Primary Assembly

    Range
    1286874..1332170 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_001092078.4 → XP_001092078.1  TNF receptor-associated factor 2 isoform X1

    See identical proteins and their annotated locations for XP_001092078.1

    UniProtKB/TrEMBL
    H9EUU8, H9Z138
    Related
    ENSMMUP00000015133.3, ENSMMUT00000016146.4
    Conserved Domains (5) summary
    cd03778
    Location:334 → 497
    MATH_TRAF2; Tumor Necrosis Factor Receptor (TNFR) Associated Factor (TRAF) family, TRAF2 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...
    TIGR00599
    Location:28 → 157
    rad18; DNA repair protein rad18
    pfam02176
    Location:178 → 235
    zf-TRAF; TRAF-type zinc finger
    cd16639
    Location:32 → 73
    RING-HC_TRAF2; RING finger, HC subclass, found in tumor necrosis factor (TNF) receptor-associated factor 2 (TRAF2) and similar proteins
    pfam16673
    Location:269 → 329
    TRAF_BIRC3_bd; TNF receptor-associated factor BIRC3 binding domain

  2. XM_001092203.4 → XP_001092203.1  TNF receptor-associated factor 2 isoform X1

    See identical proteins and their annotated locations for XP_001092203.1

    UniProtKB/TrEMBL
    H9EUU8, H9Z138
    Conserved Domains (5) summary
    cd03778
    Location:334 → 497
    MATH_TRAF2; Tumor Necrosis Factor Receptor (TNFR) Associated Factor (TRAF) family, TRAF2 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...
    TIGR00599
    Location:28 → 157
    rad18; DNA repair protein rad18
    pfam02176
    Location:178 → 235
    zf-TRAF; TRAF-type zinc finger
    cd16639
    Location:32 → 73
    RING-HC_TRAF2; RING finger, HC subclass, found in tumor necrosis factor (TNF) receptor-associated factor 2 (TRAF2) and similar proteins
    pfam16673
    Location:269 → 329
    TRAF_BIRC3_bd; TNF receptor-associated factor BIRC3 binding domain

  3. XM_015116308.2 → XP_014971794.1  TNF receptor-associated factor 2 isoform X2

    UniProtKB/TrEMBL
    A0A5F8ADX3, H9EUU8
    Conserved Domains (4) summary
    cd03778
    Location:301 → 464
    MATH_TRAF2; Tumor Necrosis Factor Receptor (TNFR) Associated Factor (TRAF) family, TRAF2 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...
    pfam00097
    Location:34 → 72
    zf-C3HC4; Zinc finger, C3HC4 type (RING finger)
    pfam02176
    Location:145 → 202
    zf-TRAF; TRAF-type zinc finger
    pfam16673
    Location:234 → 296
    TRAF_BIRC3_bd; TNF receptor-associated factor BIRC3 binding domain

  4. XM_015116306.2 → XP_014971792.1  TNF receptor-associated factor 2 isoform X1

    UniProtKB/TrEMBL
    H9EUU8, H9Z138
    Related
    ENSMMUP00000075835.1, ENSMMUT00000092436.1
    Conserved Domains (5) summary
    cd03778
    Location:334 → 497
    MATH_TRAF2; Tumor Necrosis Factor Receptor (TNFR) Associated Factor (TRAF) family, TRAF2 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...
    TIGR00599
    Location:28 → 157
    rad18; DNA repair protein rad18
    pfam02176
    Location:178 → 235
    zf-TRAF; TRAF-type zinc finger
    cd16639
    Location:32 → 73
    RING-HC_TRAF2; RING finger, HC subclass, found in tumor necrosis factor (TNF) receptor-associated factor 2 (TRAF2) and similar proteins
    pfam16673
    Location:269 → 329
    TRAF_BIRC3_bd; TNF receptor-associated factor BIRC3 binding domain

  5. XM_015116309.2 → XP_014971795.1  TNF receptor-associated factor 2 isoform X2

    UniProtKB/TrEMBL
    A0A5F8ADX3, H9EUU8
    Related
    ENSMMUP00000076072.1, ENSMMUT00000103251.1
    Conserved Domains (4) summary
    cd03778
    Location:301 → 464
    MATH_TRAF2; Tumor Necrosis Factor Receptor (TNFR) Associated Factor (TRAF) family, TRAF2 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...
    pfam00097
    Location:34 → 72
    zf-C3HC4; Zinc finger, C3HC4 type (RING finger)
    pfam02176
    Location:145 → 202
    zf-TRAF; TRAF-type zinc finger
    pfam16673
    Location:234 → 296
    TRAF_BIRC3_bd; TNF receptor-associated factor BIRC3 binding domain

  6. XM_015116310.2 → XP_014971796.1  TNF receptor-associated factor 2 isoform X3

    UniProtKB/TrEMBL
    H9EUU8
    Conserved Domains (3) summary
    cd03778
    Location:282 → 445
    MATH_TRAF2; Tumor Necrosis Factor Receptor (TNFR) Associated Factor (TRAF) family, TRAF2 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...
    pfam02176
    Location:126 → 183
    zf-TRAF; TRAF-type zinc finger
    pfam16673
    Location:215 → 277
    TRAF_BIRC3_bd; TNF receptor-associated factor BIRC3 binding domain
Nucleotide Protein
Heading Accession and Version

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