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P4HTM prolyl 4-hydroxylase, transmembrane [ Macaca mulatta (Rhesus monkey) ]

Gene ID: 708158, updated on 17-Aug-2024

Summary

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Official Symbol
P4HTMprovided by VGNC
Official Full Name
prolyl 4-hydroxylase, transmembraneprovided by VGNC
Primary source
VGNC:VGNC:75693
See related
Ensembl:ENSMMUG00000006130
Gene type
protein coding
RefSeq status
MODEL
Organism
Macaca mulatta
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs
human mouse all
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Genomic context

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See P4HTM in Genome Data Viewer
Location:
chromosome: 2
Exon count:
9
Annotation release Status Assembly Chr Location
103 current Mmul_10 (GCF_003339765.1) 2 NC_041755.1 (105063888..105082648)
102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 2 NC_027894.1 (93372387..93390728, complement)

Chromosome 2 - NC_041755.1Genomic Context describing neighboring genes Neighboring gene ARIH2 opposite strand lncRNA Neighboring gene ariadne RBR E3 ubiquitin protein ligase 2 Neighboring gene uncharacterized LOC106996921 Neighboring gene WD repeat domain 6 Neighboring gene DALR anticodon binding domain containing 3 Neighboring gene microRNA mir-425

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables L-ascorbic acid binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables procollagen-proline 4-dioxygenase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in peptidyl-proline hydroxylation to 4-hydroxy-L-proline IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
transmembrane prolyl 4-hydroxylase

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

  1. NC_041755.1 Reference Mmul_10 Primary Assembly

    Range
    105063888..105082648
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_028844103.1 → XP_028699936.1  transmembrane prolyl 4-hydroxylase isoform X3

    UniProtKB/TrEMBL
    F6PTK7, G7MIP0
    Related
    ENSMMUP00000039236.3, ENSMMUT00000046192.3
    Conserved Domains (2) summary
    smart00702
    Location:237 → 510
    P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
    pfam13499
    Location:183 → 243
    EF-hand_7; EF-hand domain pair

  2. XM_015130958.2 → XP_014986444.1  transmembrane prolyl 4-hydroxylase isoform X1

    UniProtKB/TrEMBL
    G7MIP0
    Conserved Domains (3) summary
    smart00702
    Location:237 → 478
    P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
    pfam13499
    Location:183 → 243
    EF-hand_7; EF-hand domain pair
    cl08302
    Location:185 → 243
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

  3. XM_015130959.2 → XP_014986445.1  transmembrane prolyl 4-hydroxylase isoform X2

    UniProtKB/TrEMBL
    A0A5F8ACP5, F7AZ88, H9FW46
    Related
    ENSMMUP00000074741.1, ENSMMUT00000092973.1
    Conserved Domains (3) summary
    smart00702
    Location:237 → 449
    P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
    pfam13499
    Location:183 → 243
    EF-hand_7; EF-hand domain pair
    cl08302
    Location:185 → 243
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
Nucleotide Protein
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