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GIT2 GIT ArfGAP 2 [ Macaca mulatta (Rhesus monkey) ]

Gene ID: 708092, updated on 17-Aug-2024

Summary

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Official Symbol
GIT2provided by VGNC
Official Full Name
GIT ArfGAP 2provided by VGNC
Primary source
VGNC:VGNC:73054
See related
Ensembl:ENSMMUG00000010484
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Macaca mulatta
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs
human mouse all
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Genomic context

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See GIT2 in Genome Data Viewer
Location:
chromosome: 11
Exon count:
22
Annotation release Status Assembly Chr Location
103 current Mmul_10 (GCF_003339765.1) 11 NC_041764.1 (109581508..109648042, complement)
102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 11 NC_027903.1 (109865333..109931794, complement)

Chromosome 11 - NC_041764.1Genomic Context describing neighboring genes Neighboring gene glycolipid transfer protein Neighboring gene trichoplein keratin filament binding Neighboring gene ankyrin repeat domain 13A Neighboring gene uncharacterized LOC114670946 Neighboring gene chromosome 11 C12orf76 homolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in brain development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of ARF protein signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
ARF GTPase-activating protein GIT2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001266994.1 → NP_001253923.1  ARF GTPase-activating protein GIT2

    See identical proteins and their annotated locations for NP_001253923.1

    Status: PROVISIONAL

    Source sequence(s)
    JV044205
    UniProtKB/TrEMBL
    G7N5F9, I0FIK0
    Related
    ENSMMUP00000038661.3, ENSMMUT00000045622.3
    Conserved Domains (7) summary
    smart00105
    Location:2 → 124
    ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF
    cd00204
    Location:109 → 220
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam08518
    Location:266 → 294
    GIT_SHD; Spa2 homology domain (SHD) of GIT
    pfam12205
    Location:638 → 752
    GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
    pfam12796
    Location:137 → 229
    Ank_2; Ankyrin repeats (3 copies)
    pfam16559
    Location:414 → 478
    GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor
    sd00045
    Location:137 → 165
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

  1. NC_041764.1 Reference Mmul_10 Primary Assembly

    Range
    109581508..109648042 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015152743.2 → XP_015008229.2  ARF GTPase-activating protein GIT2 isoform X9

    UniProtKB/TrEMBL
    G7N5F9
    Conserved Domains (5) summary
    sd00045
    Location:137 → 165
    ANK; ANK repeat [structural motif]
    pfam08518
    Location:265 → 292
    GIT_SHD; Spa2 homology domain (SHD) of GIT
    pfam12205
    Location:587 → 701
    GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
    pfam12796
    Location:137 → 229
    Ank_2; Ankyrin repeats (3 copies)
    cd08847
    Location:1 → 111
    ArfGap_GIT2; GIT2 GTPase activating protein for Arf

  2. XM_015152737.2 → XP_015008223.2  ARF GTPase-activating protein GIT2 isoform X3

    UniProtKB/TrEMBL
    G7N5F9
    Related
    ENSMMUP00000013752.4, ENSMMUT00000014680.4
    Conserved Domains (6) summary
    sd00045
    Location:137 → 165
    ANK; ANK repeat [structural motif]
    pfam08518
    Location:265 → 292
    GIT_SHD; Spa2 homology domain (SHD) of GIT
    pfam12205
    Location:637 → 751
    GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
    pfam16559
    Location:413 → 477
    GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor
    pfam12796
    Location:137 → 229
    Ank_2; Ankyrin repeats (3 copies)
    cd08847
    Location:1 → 111
    ArfGap_GIT2; GIT2 GTPase activating protein for Arf

  3. XM_015152736.2 → XP_015008222.2  ARF GTPase-activating protein GIT2 isoform X2

    UniProtKB/TrEMBL
    G7N5F9
    Conserved Domains (6) summary
    sd00045
    Location:137 → 165
    ANK; ANK repeat [structural motif]
    pfam08518
    Location:267 → 294
    GIT_SHD; Spa2 homology domain (SHD) of GIT
    pfam12205
    Location:639 → 753
    GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
    pfam16559
    Location:415 → 479
    GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor
    pfam12796
    Location:137 → 229
    Ank_2; Ankyrin repeats (3 copies)
    cd08847
    Location:1 → 111
    ArfGap_GIT2; GIT2 GTPase activating protein for Arf

  4. XM_015152752.2 → XP_015008238.2  ARF GTPase-activating protein GIT2 isoform X16

    UniProtKB/TrEMBL
    A0A5F7ZA17
    Related
    ENSMMUP00000013753.4, ENSMMUT00000014681.4
    Conserved Domains (5) summary
    sd00045
    Location:137 → 165
    ANK; ANK repeat [structural motif]
    cd08847
    Location:1 → 111
    ArfGap_GIT2; GIT2 GTPase activating protein for Arf
    pfam08518
    Location:268 → 296
    GIT_SHD; Spa2 homology domain (SHD) of GIT
    pfam12205
    Location:480 → 591
    GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
    pfam12796
    Location:137 → 229
    Ank_2; Ankyrin repeats (3 copies)

  5. XM_015152742.2 → XP_015008228.2  ARF GTPase-activating protein GIT2 isoform X8

    UniProtKB/TrEMBL
    G7N5F9
    Conserved Domains (5) summary
    sd00045
    Location:137 → 165
    ANK; ANK repeat [structural motif]
    pfam08518
    Location:268 → 295
    GIT_SHD; Spa2 homology domain (SHD) of GIT
    pfam12205
    Location:590 → 704
    GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
    pfam12796
    Location:137 → 229
    Ank_2; Ankyrin repeats (3 copies)
    cd08847
    Location:1 → 111
    ArfGap_GIT2; GIT2 GTPase activating protein for Arf

  6. XM_015152741.2 → XP_015008227.2  ARF GTPase-activating protein GIT2 isoform X7

    UniProtKB/TrEMBL
    I0FIK1
    Conserved Domains (6) summary
    sd00045
    Location:137 → 165
    ANK; ANK repeat [structural motif]
    pfam08518
    Location:268 → 295
    GIT_SHD; Spa2 homology domain (SHD) of GIT
    pfam12205
    Location:595 → 709
    GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
    pfam16559
    Location:416 → 465
    GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor
    pfam12796
    Location:137 → 229
    Ank_2; Ankyrin repeats (3 copies)
    cd08847
    Location:1 → 111
    ArfGap_GIT2; GIT2 GTPase activating protein for Arf

  7. XM_015152738.2 → XP_015008224.2  ARF GTPase-activating protein GIT2 isoform X4

    UniProtKB/TrEMBL
    G7N5F9
    Conserved Domains (6) summary
    sd00045
    Location:137 → 165
    ANK; ANK repeat [structural motif]
    pfam08518
    Location:268 → 295
    GIT_SHD; Spa2 homology domain (SHD) of GIT
    pfam12205
    Location:625 → 739
    GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
    pfam16559
    Location:416 → 465
    GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor
    pfam12796
    Location:137 → 229
    Ank_2; Ankyrin repeats (3 copies)
    cd08847
    Location:1 → 111
    ArfGap_GIT2; GIT2 GTPase activating protein for Arf

  8. XM_015152751.2 → XP_015008237.2  ARF GTPase-activating protein GIT2 isoform X15

    UniProtKB/TrEMBL
    A0A5F7ZA17
    Related
    ENSMMUP00000062437.1, ENSMMUT00000099676.1
    Conserved Domains (6) summary
    sd00045
    Location:137 → 165
    ANK; ANK repeat [structural motif]
    pfam08518
    Location:268 → 295
    GIT_SHD; Spa2 homology domain (SHD) of GIT
    pfam12205
    Location:527 → 641
    GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
    pfam16559
    Location:416 → 476
    GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor
    pfam12796
    Location:137 → 229
    Ank_2; Ankyrin repeats (3 copies)
    cd08847
    Location:1 → 111
    ArfGap_GIT2; GIT2 GTPase activating protein for Arf

  9. XM_015152748.2 → XP_015008234.2  ARF GTPase-activating protein GIT2 isoform X13

    UniProtKB/TrEMBL
    A0A5F7ZA17
    Conserved Domains (6) summary
    sd00045
    Location:137 → 165
    ANK; ANK repeat [structural motif]
    cd08847
    Location:1 → 111
    ArfGap_GIT2; GIT2 GTPase activating protein for Arf
    pfam08518
    Location:268 → 296
    GIT_SHD; Spa2 homology domain (SHD) of GIT
    pfam12205
    Location:555 → 671
    GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
    pfam12796
    Location:137 → 229
    Ank_2; Ankyrin repeats (3 copies)
    pfam16559
    Location:416 → 467
    GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor

  10. XM_015152739.2 → XP_015008225.2  ARF GTPase-activating protein GIT2 isoform X5

    UniProtKB/TrEMBL
    I0FIK1
    Conserved Domains (6) summary
    sd00045
    Location:137 → 165
    ANK; ANK repeat [structural motif]
    pfam08518
    Location:268 → 295
    GIT_SHD; Spa2 homology domain (SHD) of GIT
    pfam12205
    Location:610 → 724
    GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
    pfam16559
    Location:416 → 480
    GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor
    pfam12796
    Location:137 → 229
    Ank_2; Ankyrin repeats (3 copies)
    cd08847
    Location:1 → 111
    ArfGap_GIT2; GIT2 GTPase activating protein for Arf

  11. XM_015152735.2 → XP_015008221.2  ARF GTPase-activating protein GIT2 isoform X1

    UniProtKB/TrEMBL
    G7N5F9
    Conserved Domains (6) summary
    sd00045
    Location:137 → 165
    ANK; ANK repeat [structural motif]
    pfam08518
    Location:268 → 295
    GIT_SHD; Spa2 homology domain (SHD) of GIT
    pfam12205
    Location:640 → 754
    GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
    pfam16559
    Location:416 → 480
    GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor
    pfam12796
    Location:137 → 229
    Ank_2; Ankyrin repeats (3 copies)
    cd08847
    Location:1 → 111
    ArfGap_GIT2; GIT2 GTPase activating protein for Arf

  12. XM_015152744.2 → XP_015008230.2  ARF GTPase-activating protein GIT2 isoform X10

    UniProtKB/TrEMBL
    A0A5F7ZJ47
    Conserved Domains (6) summary
    sd00045
    Location:75 → 103
    ANK; ANK repeat [structural motif]
    pfam08518
    Location:206 → 233
    GIT_SHD; Spa2 homology domain (SHD) of GIT
    pfam12205
    Location:578 → 692
    GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
    pfam16559
    Location:354 → 418
    GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor
    pfam12796
    Location:75 → 167
    Ank_2; Ankyrin repeats (3 copies)
    cl28907
    Location:1 → 49
    ArfGap; GTPase-activating protein (GAP) for the ADP ribosylation factors (ARFs)

  13. XM_015152745.2 → XP_015008231.2  ARF GTPase-activating protein GIT2 isoform X10

    UniProtKB/TrEMBL
    A0A5F7ZJ47
    Related
    ENSMMUP00000065201.1, ENSMMUT00000086472.1
    Conserved Domains (6) summary
    sd00045
    Location:75 → 103
    ANK; ANK repeat [structural motif]
    pfam08518
    Location:206 → 233
    GIT_SHD; Spa2 homology domain (SHD) of GIT
    pfam12205
    Location:578 → 692
    GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
    pfam16559
    Location:354 → 418
    GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor
    pfam12796
    Location:75 → 167
    Ank_2; Ankyrin repeats (3 copies)
    cl28907
    Location:1 → 49
    ArfGap; GTPase-activating protein (GAP) for the ADP ribosylation factors (ARFs)

  14. XM_015152747.2 → XP_015008233.2  ARF GTPase-activating protein GIT2 isoform X12

    UniProtKB/TrEMBL
    H9YWJ1, I0FIK1
    Conserved Domains (5) summary
    sd00045
    Location:137 → 165
    ANK; ANK repeat [structural motif]
    pfam08518
    Location:266 → 293
    GIT_SHD; Spa2 homology domain (SHD) of GIT
    pfam12205
    Location:558 → 672
    GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
    pfam12796
    Location:137 → 229
    Ank_2; Ankyrin repeats (3 copies)
    cd08847
    Location:1 → 111
    ArfGap_GIT2; GIT2 GTPase activating protein for Arf

  15. XM_015152740.2 → XP_015008226.2  ARF GTPase-activating protein GIT2 isoform X6

    UniProtKB/TrEMBL
    H9EU99, I0FIK1
    Related
    ENSMMUP00000081123.1, ENSMMUT00000084215.1
    Conserved Domains (6) summary
    sd00045
    Location:137 → 165
    ANK; ANK repeat [structural motif]
    pfam08518
    Location:266 → 293
    GIT_SHD; Spa2 homology domain (SHD) of GIT
    pfam12205
    Location:608 → 722
    GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
    pfam16559
    Location:414 → 478
    GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor
    pfam12796
    Location:137 → 229
    Ank_2; Ankyrin repeats (3 copies)
    cd08847
    Location:1 → 111
    ArfGap_GIT2; GIT2 GTPase activating protein for Arf

  16. XM_015152749.2 → XP_015008235.2  ARF GTPase-activating protein GIT2 isoform X14

    UniProtKB/TrEMBL
    I0FIK1
    Conserved Domains (6) summary
    sd00045
    Location:75 → 103
    ANK; ANK repeat [structural motif]
    pfam08518
    Location:204 → 231
    GIT_SHD; Spa2 homology domain (SHD) of GIT
    pfam12205
    Location:546 → 660
    GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
    pfam16559
    Location:352 → 416
    GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor
    pfam12796
    Location:75 → 167
    Ank_2; Ankyrin repeats (3 copies)
    cl28907
    Location:1 → 49
    ArfGap; GTPase-activating protein (GAP) for the ADP ribosylation factors (ARFs)

  17. XM_015152746.2 → XP_015008232.2  ARF GTPase-activating protein GIT2 isoform X11

    UniProtKB/TrEMBL
    I0FIK1
    Conserved Domains (5) summary
    sd00045
    Location:137 → 165
    ANK; ANK repeat [structural motif]
    pfam08518
    Location:268 → 295
    GIT_SHD; Spa2 homology domain (SHD) of GIT
    pfam12205
    Location:560 → 674
    GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
    pfam12796
    Location:137 → 229
    Ank_2; Ankyrin repeats (3 copies)
    cd08847
    Location:1 → 111
    ArfGap_GIT2; GIT2 GTPase activating protein for Arf

  18. XM_015152753.2 → XP_015008239.1  ARF GTPase-activating protein GIT2 isoform X17

    UniProtKB/TrEMBL
    F7BFP0, F7BFR5
    Related
    ENSMMUP00000013751.4, ENSMMUT00000014679.4
    Conserved Domains (6) summary
    smart00105
    Location:2 → 124
    ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF
    cd00204
    Location:109 → 220
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam08518
    Location:266 → 294
    GIT_SHD; Spa2 homology domain (SHD) of GIT
    pfam12796
    Location:137 → 229
    Ank_2; Ankyrin repeats (3 copies)
    pfam16559
    Location:414 → 465
    GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor
    sd00045
    Location:137 → 165
    ANK; ANK repeat [structural motif]
Nucleotide Protein
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