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Arhgap45 Rho GTPase activating protein 45 [ Mus musculus (house mouse) ]

Gene ID: 70719, updated on 27-Nov-2024

Summary

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Official Symbol
Arhgap45provided by MGI
Official Full Name
Rho GTPase activating protein 45provided by MGI
Primary source
MGI:MGI:1917969
See related
Ensembl:ENSMUSG00000035697 AllianceGenome:MGI:1917969
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ha-1; Hmha1; 6330406L22Rik
Summary
Predicted to enable GTPase activator activity. Predicted to be involved in negative regulation of small GTPase mediated signal transduction. Predicted to be located in cytosol and plasma membrane. Predicted to be active in membrane. Orthologous to human ARHGAP45 (Rho GTPase activating protein 45). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in thymus adult (RPKM 412.6), spleen adult (RPKM 216.3) and 2 other tissues See more
Orthologs
human all
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Genomic context

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See Arhgap45 in Genome Data Viewer
Location:
10 C1; 10 39.72 cM
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (79852505..79867305)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (80016672..80031471)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene calponin 2 Neighboring gene STARR-positive B cell enhancer ABC_E1805 Neighboring gene ATP-binding cassette, sub-family A member 7 Neighboring gene STARR-positive B cell enhancer ABC_E2948 Neighboring gene STARR-positive B cell enhancer ABC_E6880 Neighboring gene polymerase (RNA) II (DNA directed) polypeptide E Neighboring gene STARR-seq mESC enhancer starr_27262 Neighboring gene STARR-positive B cell enhancer ABC_E900 Neighboring gene glutathione peroxidase 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. ARHGAP45 controls naïve T- and B-cell entry into lymph nodes and T-cell progenitor thymus seeding. He L, et al. EMBO Rep, 2021 Apr 7. PMID 33719206, Free PMC Article
  2. Quantitative interactomics in primary T cells unveils TCR signal diversification extent and dynamics. Voisinne G, et al. Nat Immunol, 2019 Nov. PMID 31591574, Free PMC Article
  3. ATG5 is required for B cell polarization and presentation of particulate antigens. Arbogast F, et al. Autophagy, 2019 Feb. PMID 30196744, Free PMC Article
  4. Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function. Zhang T, et al. Sci Rep, 2017 Apr 5. PMID 28378742, Free PMC Article
  5. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0223

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of small GTPase mediated signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of small GTPase mediated signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in ruffle membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
rho GTPase-activating protein 45
Names
histocompatibility (minor) HA-1
minor histocompatibility protein HA-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001142701.1 → NP_001136173.1  rho GTPase-activating protein 45 isoform 1

    See identical proteins and their annotated locations for NP_001136173.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK159194, AK159474, BB733889
    Consensus CDS
    CCDS48624.1
    UniProtKB/Swiss-Prot
    Q3TBD2, Q3TDD2, Q3TSW0, Q3TXM6, Q3UZ72, Q8BI83, Q9CU46
    UniProtKB/TrEMBL
    G3X9Q3
    Related
    ENSMUSP00000097100.4, ENSMUST00000099501.10
    Conserved Domains (3) summary
    smart00109
    Location:699 → 744
    C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
    cl02570
    Location:756 → 966
    RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
    cl12013
    Location:278 → 529
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  2. NM_001347074.1 → NP_001334003.1  rho GTPase-activating protein 45 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AI430932, AK151423, AK159194, AK159474, BY168122
    Consensus CDS
    CCDS83725.1
    UniProtKB/Swiss-Prot
    Q3TBD2, Q3TDD2, Q3TSW0, Q3TXM6, Q3UZ72, Q8BI83, Q9CU46
    UniProtKB/TrEMBL
    D3Z7R7
    Related
    ENSMUSP00000101012.2, ENSMUST00000105373.8

  3. NM_027521.3 → NP_081797.1  rho GTPase-activating protein 45 isoform 2

    See identical proteins and their annotated locations for NP_081797.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate 5' sequence, as compared to variant 1. The resulting isoform (2) has a shorter and different N-terminus, as compared to isoform 1.
    Source sequence(s)
    BB733889, BC053750
    Consensus CDS
    CCDS24005.1
    UniProtKB/Swiss-Prot
    Q3TBD2, Q3TDD2, Q3TSW0, Q3TXM6, Q3UZ72, Q8BI83, Q9CU46
    Related
    ENSMUSP00000041019.7, ENSMUST00000043311.7
    Conserved Domains (3) summary
    smart00109
    Location:583 → 628
    C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
    cl02570
    Location:640 → 850
    RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
    cl12013
    Location:162 → 413
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    79852505..79867305
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030245276.2 → XP_030101136.1  rho GTPase-activating protein 45 isoform X3

    Related
    ENSMUST00000140974.8
    Conserved Domains (2) summary
    smart00109
    Location:172 → 217
    C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
    cl02570
    Location:229 → 439
    RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...

  2. XM_006514109.2 → XP_006514172.1  rho GTPase-activating protein 45 isoform X1

    UniProtKB/Swiss-Prot
    Q3TBD2, Q3TDD2, Q3TSW0, Q3TXM6, Q3UZ72, Q8BI83, Q9CU46
    Conserved Domains (3) summary
    smart00109
    Location:540 → 585
    C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
    cl02570
    Location:597 → 807
    RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
    cl12013
    Location:119 → 370
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  3. XM_006514110.1 → XP_006514173.1  rho GTPase-activating protein 45 isoform X2

    Related
    ENSMUST00000150022.2
    Conserved Domains (3) summary
    smart00109
    Location:458 → 503
    C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
    cl02570
    Location:515 → 725
    RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
    cl12013
    Location:37 → 288
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

RNA

  1. XR_001779599.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3TBD2.2 GenPept UniProtKB/Swiss-Prot:Q3TBD2

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