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PIAS3 protein inhibitor of activated STAT 3 [ Macaca mulatta (Rhesus monkey) ]

Gene ID: 706775, updated on 17-Aug-2024

Summary

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Official Symbol
PIAS3provided by VGNC
Official Full Name
protein inhibitor of activated STAT 3provided by VGNC
Primary source
VGNC:VGNC:75811
See related
Ensembl:ENSMMUG00000016733
Gene type
protein coding
RefSeq status
MODEL
Organism
Macaca mulatta
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs
human mouse all
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Genomic context

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See PIAS3 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
14
Annotation release Status Assembly Chr Location
103 current Mmul_10 (GCF_003339765.1) 1 NC_041754.1 (103418468..103428788)
102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 1 NC_027893.1 (123490152..123501359)

Chromosome 1 - NC_041754.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC114677580 Neighboring gene integrin subunit alpha 10 Neighboring gene ankyrin repeat domain 35 Neighboring gene nudix hydrolase 17 Neighboring gene RNA polymerase III subunit C Neighboring gene ring finger protein 115 Neighboring gene ribosome biogenesis protein NSA2 homolog pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Suppressed Th17 levels correlate with elevated PIAS3, SHP2, and SOCS3 expression in CD4 T cells during acute simian immunodeficiency virus infection. Bixler SL, et al. J Virol, 2013 Jun. PMID 23596301, Free PMC Article
  2. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
  3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Suppressed Th17 levels correlated with upregulated expression of negative regulatory genes, PIAS3, SHP2, and SOCS3 in CD4 T cells during acute SIV infection.
    Title: Suppressed Th17 levels correlate with elevated PIAS3, SHP2, and SOCS3 expression in CD4 T cells during acute simian immunodeficiency virus infection.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables SUMO ligase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables transcription coregulator activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein sumoylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
E3 SUMO-protein ligase PIAS3; LOW QUALITY PROTEIN: E3 SUMO-protein ligase PIAS3

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

  1. NC_041754.1 Reference Mmul_10 Primary Assembly

    Range
    103418468..103428788
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015150210.2 → XP_015005696.2  LOW QUALITY PROTEIN: E3 SUMO-protein ligase PIAS3

    UniProtKB/TrEMBL
    G7MG24
    Related
    ENSMMUT00000065403.2
    Conserved Domains (3) summary
    smart00513
    Location:11 → 36
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    cd16790
    Location:324 → 371
    SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
    pfam14324
    Location:130 → 272
    PINIT; PINIT domain
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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