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Sik3 SIK family kinase 3 [ Mus musculus (house mouse) ]

Gene ID: 70661, updated on 27-Nov-2024

Summary

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Official Symbol
Sik3provided by MGI
Official Full Name
SIK family kinase 3provided by MGI
Primary source
MGI:MGI:2446296
See related
Ensembl:ENSMUSG00000034135 AllianceGenome:MGI:2446296
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Qsk; SIK-3; mKIAA0999; 5730525O22Rik; 9030204A07Rik
Summary
Predicted to enable ATP binding activity; magnesium ion binding activity; and protein kinase activity. Acts upstream of or within endochondral bone morphogenesis; limb morphogenesis; and regulation of protein localization. Located in cytoplasm. Is expressed in Meckel's cartilage and vibrissa. Orthologous to human SIK3 (SIK family kinase 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in cerebellum adult (RPKM 12.2), adrenal adult (RPKM 10.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Sik3 in Genome Data Viewer
Location:
9 A5.2; 9 25.36 cM
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (45924099..46135492)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (46012820..46224194)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA A830035O19 gene Neighboring gene SID1 transmembrane family, member 2 Neighboring gene platelet-activating factor acetylhydrolase, isoform 1b, subunit 2 Neighboring gene STARR-positive B cell enhancer ABC_E8289 Neighboring gene STARR-seq mESC enhancer starr_24013 Neighboring gene STARR-seq mESC enhancer starr_24014 Neighboring gene predicted gene, 46110 Neighboring gene STARR-seq mESC enhancer starr_24018 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:45928283-45928392 Neighboring gene POU domain, class 5, transcription factor 1, related sequence 9 Neighboring gene STARR-seq mESC enhancer starr_24022 Neighboring gene apolipoprotein A-I Neighboring gene apolipoprotein C-III

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Impact of the SIK3 pathway inhibition on osteoclast differentiation via oxidative phosphorylation. Kamei K, et al. J Bone Miner Res, 2024 Sep 2. PMID 39030684
  2. Changes in acetyl-CoA mediate Sik3-induced maturation of chondrocytes in endochondral bone formation. Kosai A, et al. Biochem Biophys Res Commun, 2019 Sep 3. PMID 31280862
  3. Involvement of SIK3 in glucose and lipid homeostasis in mice. Uebi T, et al. PLoS One, 2012. PMID 22662228, Free PMC Article
  4. A single phosphorylation site of SIK3 regulates daily sleep amounts and sleep need in mice. Honda T, et al. Proc Natl Acad Sci U S A, 2018 Oct 9. PMID 30254177, Free PMC Article
  5. Metabolomic and pharmacologic analyses of brain substances associated with sleep pressure in mice. Suzuki-Abe H, et al. Neurosci Res, 2022 Apr. PMID 34856199

See all (64) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Impact of the SIK3 pathway inhibition on osteoclast differentiation via oxidative phosphorylation.
    Title: Impact of the SIK3 pathway inhibition on osteoclast differentiation via oxidative phosphorylation.
  2. Knockdown of SIK3 in the CA1 Region can Reduce Seizure Susceptibility in Mice by Inhibiting Decreases in GABAAR alpha1 Expression.
    Title: Knockdown of SIK3 in the CA1 Region can Reduce Seizure Susceptibility in Mice by Inhibiting Decreases in GABA(A)R α1 Expression.
  3. Sleep need, the key regulator of sleep homeostasis, is indicated and controlled by phosphorylation of threonine 221 in salt-inducible kinase 3.
    Title: Sleep need, the key regulator of sleep homeostasis, is indicated and controlled by phosphorylation of threonine 221 in salt-inducible kinase 3.
  4. Salt-inducible kinase inhibition promotes the adipocyte thermogenic program and adipose tissue browning.
    Title: Salt-inducible kinase inhibition promotes the adipocyte thermogenic program and adipose tissue browning.
  5. Face validation and pharmacologic analysis of Sik3[Sleepy] mutant mouse as a possible model of idiopathic hypersomnia.
    Title: Face validation and pharmacologic analysis of Sik3(Sleepy) mutant mouse as a possible model of idiopathic hypersomnia.
  6. SIK3-HDAC4 in the suprachiasmatic nucleus regulates the timing of arousal at the dark onset and circadian period in mice.
    Title: SIK3-HDAC4 in the suprachiasmatic nucleus regulates the timing of arousal at the dark onset and circadian period in mice.
  7. Kinase signalling in excitatory neurons regulates sleep quantity and depth.
    Title: Kinase signalling in excitatory neurons regulates sleep quantity and depth.
  8. Regulation of sleep quantity and intensity by long and short isoforms of SLEEPY kinase.
    Title: Regulation of sleep quantity and intensity by long and short isoforms of SLEEPY kinase.
  9. The role of microglial/macrophagic salt-inducible kinase 3 on normal and excessive phagocytosis after transient focal cerebral ischemia.
    Title: The role of microglial/macrophagic salt-inducible kinase 3 on normal and excessive phagocytosis after transient focal cerebral ischemia.
  10. Salt inducible kinases 2 and 3 are required for thymic T cell development.
    Title: Salt inducible kinases 2 and 3 are required for thymic T cell development.
Submit: New GeneRIF Correction See all GeneRIFs (28)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC90906, MGC91236

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 3-phosphoinositide-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables AMP-activated protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables ATP binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables DNA-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables Rho-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables eukaryotic translation initiation factor 2alpha kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AS121 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AT120 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AXS139 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2BS14 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2BS36 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3S10 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3S28 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3S57 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T11 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T3 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T45 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T6 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H4S1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables magnesium ion binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables ribosomal protein S6 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables tau-protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cartilage development involved in endochondral bone morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within endochondral ossification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within limb morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of TORC1 signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of TORC1 signaling ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of TORC2 signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of TORC2 signaling ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within regulation of protein localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within skeletal system morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
serine/threonine-protein kinase SIK3
Names
salt-inducible kinase 3
serine/threonine-protein kinase QSK
NP_081774.3
XP_006510653.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_027498.3 → NP_081774.3  serine/threonine-protein kinase SIK3

    Status: VALIDATED

    Source sequence(s)
    AK129257, BC080688, BG229919, CJ171970
    Consensus CDS
    CCDS23140.2
    UniProtKB/Swiss-Prot
    E9PU87, Q641L5, Q66JZ5, Q6P4S6, Q6ZQ09, Q8K075, Q9CYD5
    UniProtKB/TrEMBL
    F6S7W6
    Related
    ENSMUSP00000121032.2, ENSMUST00000126865.8
    Conserved Domains (3) summary
    smart00220
    Location:66 → 317
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14410
    Location:346 → 390
    UBA_SIK3; UBA domain found in salt-inducible kinase 3 (SIK3)
    cd14071
    Location:65 → 317
    STKc_SIK; Catalytic domain of the Serine/Threonine Kinases, Salt-Inducible kinases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    45924099..46135492
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006510590.4 → XP_006510653.1  serine/threonine-protein kinase SIK3 isoform X1

    UniProtKB/TrEMBL
    F6S7W6
    Related
    ENSMUSP00000112749.3, ENSMUST00000120463.9
    Conserved Domains (2) summary
    cd14410
    Location:346 → 390
    UBA_SIK3; UBA domain found in salt-inducible kinase 3 (SIK3)
    cd14071
    Location:65 → 317
    STKc_SIK; Catalytic domain of the Serine/Threonine Kinases, Salt-Inducible kinases
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6P4S6.4 GenPept UniProtKB/Swiss-Prot:Q6P4S6

Gene LinkOut

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