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HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 [ Macaca mulatta (Rhesus monkey) ]

Gene ID: 706308, updated on 17-Aug-2024

Summary

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Official Symbol
HERC1provided by VGNC
Official Full Name
HECT and RLD domain containing E3 ubiquitin protein ligase family member 1provided by VGNC
Primary source
VGNC:VGNC:73364
See related
Ensembl:ENSMMUG00000012117
Gene type
protein coding
RefSeq status
MODEL
Organism
Macaca mulatta
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs
human mouse all
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Genomic context

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See HERC1 in Genome Data Viewer
Location:
chromosome: 7
Exon count:
79
Annotation release Status Assembly Chr Location
103 current Mmul_10 (GCF_003339765.1) 7 NC_041760.1 (40057621..40282977, complement)
102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 7 NC_027899.1 (40196953..40422659, complement)

Chromosome 7 - NC_041760.1Genomic Context describing neighboring genes Neighboring gene ubiquitin specific peptidase 3 Neighboring gene F-box and leucine-rich protein 22-like Neighboring gene F-box and leucine rich repeat protein 22 Neighboring gene microRNA mir-422a Neighboring gene death associated protein kinase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ubiquitin-protein transferase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
probable E3 ubiquitin-protein ligase HERC1
Names
hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 1
putative E3 ubiquitin-protein ligase HERC1
XP_014997914.2
XP_014997920.2
XP_014997922.2
XP_028706850.1
XP_028706851.1
XP_028706852.1
XP_028706853.1
XP_028706855.1
XP_028706856.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

  1. NC_041760.1 Reference Mmul_10 Primary Assembly

    Range
    40057621..40282977 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015142436.2 → XP_014997922.2  probable E3 ubiquitin-protein ligase HERC1 isoform X9

    UniProtKB/TrEMBL
    H9EUE9
    Related
    ENSMMUP00000015885.4, ENSMMUT00000016962.4
    Conserved Domains (6) summary
    COG5184
    Location:374 → 731
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cd00078
    Location:4473 → 4841
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14401
    Location:2753 → 2796
    UBA_HERC1; UBA domain found in probable E3 ubiquitin-protein ligase HERC1 and similar proteins
    sd00039
    Location:3432 → 3475
    7WD40; WD40 repeat [structural motif]
    cd12881
    Location:2032 → 2189
    SPRY_HERC1; SPRY domain in HERC1
    cl29593
    Location:3424 → 3775
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  2. XM_015142434.2 → XP_014997920.2  probable E3 ubiquitin-protein ligase HERC1 isoform X8

    UniProtKB/TrEMBL
    H9EUE9
    Conserved Domains (6) summary
    COG5184
    Location:374 → 731
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cd00078
    Location:4490 → 4858
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14401
    Location:2753 → 2796
    UBA_HERC1; UBA domain found in probable E3 ubiquitin-protein ligase HERC1 and similar proteins
    sd00039
    Location:3449 → 3492
    7WD40; WD40 repeat [structural motif]
    cd12881
    Location:2032 → 2189
    SPRY_HERC1; SPRY domain in HERC1
    cl29593
    Location:3441 → 3792
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  3. XM_028851022.1 → XP_028706855.1  probable E3 ubiquitin-protein ligase HERC1 isoform X5

    UniProtKB/TrEMBL
    H9EUE9
    Conserved Domains (6) summary
    COG5184
    Location:374 → 731
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cd00078
    Location:4512 → 4880
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14401
    Location:2775 → 2818
    UBA_HERC1; UBA domain found in probable E3 ubiquitin-protein ligase HERC1 and similar proteins
    sd00039
    Location:3471 → 3514
    7WD40; WD40 repeat [structural motif]
    cd12881
    Location:2054 → 2211
    SPRY_HERC1; SPRY domain in HERC1
    cl29593
    Location:3463 → 3814
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  4. XM_015142428.2 → XP_014997914.2  probable E3 ubiquitin-protein ligase HERC1 isoform X7

    UniProtKB/TrEMBL
    H9EUE9
    Conserved Domains (6) summary
    COG5184
    Location:374 → 731
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cd00078
    Location:4499 → 4867
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14401
    Location:2762 → 2805
    UBA_HERC1; UBA domain found in probable E3 ubiquitin-protein ligase HERC1 and similar proteins
    sd00039
    Location:3458 → 3501
    7WD40; WD40 repeat [structural motif]
    cd12881
    Location:2041 → 2198
    SPRY_HERC1; SPRY domain in HERC1
    cl29593
    Location:3450 → 3801
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  5. XM_028851018.1 → XP_028706851.1  probable E3 ubiquitin-protein ligase HERC1 isoform X2

    UniProtKB/TrEMBL
    H9EUE9
    Conserved Domains (6) summary
    COG5184
    Location:374 → 731
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cd00078
    Location:4520 → 4888
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14401
    Location:2783 → 2826
    UBA_HERC1; UBA domain found in probable E3 ubiquitin-protein ligase HERC1 and similar proteins
    sd00039
    Location:3479 → 3522
    7WD40; WD40 repeat [structural motif]
    cd12881
    Location:2062 → 2219
    SPRY_HERC1; SPRY domain in HERC1
    cl29593
    Location:3471 → 3822
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  6. XM_028851020.1 → XP_028706853.1  probable E3 ubiquitin-protein ligase HERC1 isoform X4

    UniProtKB/TrEMBL
    F7H8R5
    Conserved Domains (6) summary
    COG5184
    Location:374 → 731
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cd00078
    Location:4513 → 4881
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14401
    Location:2776 → 2819
    UBA_HERC1; UBA domain found in probable E3 ubiquitin-protein ligase HERC1 and similar proteins
    sd00039
    Location:3472 → 3515
    7WD40; WD40 repeat [structural motif]
    cd12881
    Location:2063 → 2220
    SPRY_HERC1; SPRY domain in HERC1
    cl29593
    Location:3464 → 3815
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  7. XM_028851019.1 → XP_028706852.1  probable E3 ubiquitin-protein ligase HERC1 isoform X3

    UniProtKB/TrEMBL
    H9G1F1
    Conserved Domains (6) summary
    COG5184
    Location:374 → 731
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cd00078
    Location:4514 → 4882
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14401
    Location:2784 → 2827
    UBA_HERC1; UBA domain found in probable E3 ubiquitin-protein ligase HERC1 and similar proteins
    sd00039
    Location:3473 → 3516
    7WD40; WD40 repeat [structural motif]
    cd12881
    Location:2063 → 2220
    SPRY_HERC1; SPRY domain in HERC1
    cl29593
    Location:3465 → 3816
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  8. XM_028851023.1 → XP_028706856.1  probable E3 ubiquitin-protein ligase HERC1 isoform X6

    UniProtKB/TrEMBL
    H9EUE9
    Conserved Domains (6) summary
    COG5184
    Location:374 → 731
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cd00078
    Location:4504 → 4872
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14401
    Location:2784 → 2827
    UBA_HERC1; UBA domain found in probable E3 ubiquitin-protein ligase HERC1 and similar proteins
    sd00039
    Location:3463 → 3506
    7WD40; WD40 repeat [structural motif]
    cd12881
    Location:2063 → 2220
    SPRY_HERC1; SPRY domain in HERC1
    cl29593
    Location:3455 → 3806
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  9. XM_028851017.1 → XP_028706850.1  probable E3 ubiquitin-protein ligase HERC1 isoform X1

    UniProtKB/TrEMBL
    H9EUE9
    Conserved Domains (6) summary
    COG5184
    Location:374 → 731
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cd00078
    Location:4521 → 4889
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14401
    Location:2784 → 2827
    UBA_HERC1; UBA domain found in probable E3 ubiquitin-protein ligase HERC1 and similar proteins
    sd00039
    Location:3480 → 3523
    7WD40; WD40 repeat [structural motif]
    cd12881
    Location:2063 → 2220
    SPRY_HERC1; SPRY domain in HERC1
    cl29593
    Location:3472 → 3823
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
Nucleotide Protein
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