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AXL AXL receptor tyrosine kinase [ Macaca mulatta (Rhesus monkey) ]

Gene ID: 706123, updated on 17-Aug-2024

Summary

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Official Symbol
AXLprovided by VGNC
Official Full Name
AXL receptor tyrosine kinaseprovided by VGNC
Primary source
VGNC:VGNC:70200
See related
Ensembl:ENSMMUG00000009145
Gene type
protein coding
RefSeq status
MODEL
Organism
Macaca mulatta
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs
human mouse all
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Genomic context

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See AXL in Genome Data Viewer
Location:
chromosome: 19
Exon count:
20
Annotation release Status Assembly Chr Location
103 current Mmul_10 (GCF_003339765.1) 19 NC_041772.1 (40458531..40504554)
102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 19 NC_027911.1 (37048805..37101142)

Chromosome 19 - NC_041772.1Genomic Context describing neighboring genes Neighboring gene cytochrome P450 family 2 subfamily A member 28, pseudogene Neighboring gene cytochrome P450 family 2 subfamily S member 1 Neighboring gene transfer RNA lysine (anticodon UUU) Neighboring gene heterogeneous nuclear ribonucleoprotein U like 1 Neighboring gene coiled-coil domain containing 97

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables transmembrane receptor protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell migration IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in natural killer cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in nervous system development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in phagocytosis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in platelet activation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of receptor complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
tyrosine-protein kinase receptor UFO

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

  1. NC_041772.1 Reference Mmul_10 Primary Assembly

    Range
    40458531..40504554
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_028839773.1 → XP_028695606.1  tyrosine-protein kinase receptor UFO isoform X1

    UniProtKB/TrEMBL
    A0A8J8XYI9, G7NLI7, I0FHQ1
    Conserved Domains (5) summary
    cd05749
    Location:141 → 222
    Ig2_Axl_Tyro3_like; Second immunoglobulin (Ig)-like domain of Axl/Tyro3 family receptor tyrosine kinases (RTKs)
    cd00063
    Location:225 → 328
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd05075
    Location:552 → 828
    PTKc_Axl; Catalytic domain of the Protein Tyrosine Kinase, Axl
    cd00096
    Location:53 → 119
    Ig; Immunoglobulin domain
    pfam00041
    Location:335 → 417
    fn3; Fibronectin type III domain

  2. XM_028839774.1 → XP_028695607.1  tyrosine-protein kinase receptor UFO isoform X2

    UniProtKB/TrEMBL
    A0A1D5Q330, A0A8J8XYI9, G7NLI7, I0FHQ1
    Related
    ENSMMUP00000042442.2, ENSMMUT00000074621.2
    Conserved Domains (5) summary
    cd05749
    Location:141 → 222
    Ig2_Axl_Tyro3_like; Second immunoglobulin (Ig)-like domain of Axl/Tyro3 family receptor tyrosine kinases (RTKs)
    cd00063
    Location:225 → 328
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd05075
    Location:535 → 811
    PTKc_Axl; Catalytic domain of the Protein Tyrosine Kinase, Axl
    cd00096
    Location:53 → 119
    Ig; Immunoglobulin domain
    pfam00041
    Location:335 → 417
    fn3; Fibronectin type III domain

  3. XM_028839775.1 → XP_028695608.1  tyrosine-protein kinase receptor UFO isoform X3

    UniProtKB/TrEMBL
    F7E4X5, I0FHQ2
    Related
    ENSMMUP00000011992.4, ENSMMUT00000012790.4
    Conserved Domains (5) summary
    cd05749
    Location:141 → 222
    Ig2_Axl_Tyro3_like; Second immunoglobulin (Ig)-like domain of Axl/Tyro3 family receptor tyrosine kinases (RTKs)
    cd00063
    Location:225 → 328
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd05075
    Location:526 → 802
    PTKc_Axl; Catalytic domain of the Protein Tyrosine Kinase, Axl
    cd00096
    Location:53 → 119
    Ig; Immunoglobulin domain
    pfam00041
    Location:335 → 417
    fn3; Fibronectin type III domain
Nucleotide Protein
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