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SOS2 SOS Ras/Rho guanine nucleotide exchange factor 2 [ Macaca mulatta (Rhesus monkey) ]

Gene ID: 705601, updated on 17-Aug-2024

Summary

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Official Symbol
SOS2provided by VGNC
Official Full Name
SOS Ras/Rho guanine nucleotide exchange factor 2provided by VGNC
Primary source
VGNC:VGNC:77838
See related
Ensembl:ENSMMUG00000007464
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Macaca mulatta
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs
human mouse all
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Genomic context

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See SOS2 in Genome Data Viewer
Location:
chromosome: 7
Exon count:
23
Annotation release Status Assembly Chr Location
103 current Mmul_10 (GCF_003339765.1) 7 NC_041760.1 (112325415..112438613, complement)
102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 7 NC_027899.1 (112128084..112241794, complement)

Chromosome 7 - NC_041760.1Genomic Context describing neighboring genes Neighboring gene putative uncharacterized protein encoded by LINC01599 Neighboring gene valosin containing protein lysine methyltransferase Neighboring gene L-2-hydroxyglutarate dehydrogenase Neighboring gene 28S ribosomal protein S5, mitochondrial pseudogene Neighboring gene distal membrane arm assembly component 2 like Neighboring gene cyclin dependent kinase like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in Ras protein signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
son of sevenless homolog 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001260585.1 → NP_001247514.1  son of sevenless homolog 2

    See identical proteins and their annotated locations for NP_001247514.1

    Status: PROVISIONAL

    Source sequence(s)
    JU336053
    UniProtKB/TrEMBL
    H9FYU7, H9ZCQ2
    Related
    ENSMMUP00000046283.2, ENSMMUT00000073733.2
    Conserved Domains (7) summary
    smart00229
    Location:595 → 739
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00155
    Location:774 → 1013
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
    cd00160
    Location:199 → 386
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01261
    Location:437 → 543
    PH_SOS; Son of Sevenless (SOS) Pleckstrin homology (PH) domain
    pfam00125
    Location:63 → 169
    Histone; Core histone H2A/H2B/H3/H4
    pfam00169
    Location:443 → 544
    PH; PH domain
    cl23907
    Location:97 → 147
    H2A; Histone 2A; H2A is a subunit of the nucleosome. The nucleosome is an octamer containing two H2A, H2B, H3, and H4 subunits. The H2A subunit performs essential roles in maintaining structural integrity of the nucleosome, chromatin condensation, and binding ...

RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

  1. NC_041760.1 Reference Mmul_10 Primary Assembly

    Range
    112325415..112438613 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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