TERF2 telomeric repeat binding factor 2 [Macaca mulatta (Rhesus monkey)] - Gene

Summary

Official Symbol: TERF2provided by VGNC
Official Full Name: telomeric repeat binding factor 2provided by VGNC
Primary source: VGNC:VGNC:78312
See related: Ensembl:ENSMMUG00000016633
Gene type: protein coding
RefSeq status: MODEL
Organism: Macaca mulatta
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 20

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
103	current	Mmul_10 (GCF_003339765.1)	20	NC_041773.1 (56608011..56640923, complement)
102	previous assembly	Mmul_8.0.1 (GCF_000772875.2)	20	NC_027912.1 (53788315..53820050, complement)

Chromosome 20 - NC_041773.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH119887 (e-PCR)
- UniSTS:133632

RH65311 (e-PCR)
- UniSTS:83771

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables G-rich strand telomeric DNA binding	IEA Inferred from Electronic Annotation more info	PubMed
enables double-stranded telomeric DNA binding	IEA Inferred from Electronic Annotation more info	PubMed
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info	PubMed
enables telomerase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of telomere maintenance via recombination	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of telomeric D-loop disassembly	IEA Inferred from Electronic Annotation more info	PubMed
involved_in protection from non-homologous end joining at telomere	IEA Inferred from Electronic Annotation more info	PubMed
involved_in protein localization to chromosome, telomeric region	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of telomere maintenance via telomerase	IEA Inferred from Electronic Annotation more info	PubMed
involved_in telomeric D-loop disassembly	IEA Inferred from Electronic Annotation more info	PubMed
involved_in telomeric loop formation	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in chromosome, telomeric region	IEA Inferred from Electronic Annotation more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info	PubMed
part_of shelterin complex	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: telomeric repeat-binding factor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

NC_041773.1 Reference Mmul_10 Primary Assembly

Range

56608011..56640923 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_015126498.2 → XP_014981984.1 telomeric repeat-binding factor 2 isoform X2

UniProtKB/TrEMBL

I2CTL7

Conserved Domains (4) summary

smart00717
Location:488 → 537

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

cd11660
Location:489 → 537

SANT_TRF; Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family

cd00280
Location:87 → 286

TRFH; Telomeric Repeat binding Factor or TTAGGG Repeat binding Factor, central (dimerization) domain Homology; TRFH. Telomeres are protein/DNA complexes that make up the physical ends of eukaryotic linear chromosomes and are essential for chromosome stability, ...

pfam16772
Location:318 → 358

TERF2_RBM; Telomeric repeat-binding factor 2 Rap1-binding motif
XM_015126497.2 → XP_014981983.1 telomeric repeat-binding factor 2 isoform X1

UniProtKB/TrEMBL

F6TW69, I2CTL7

Related

ENSMMUP00000021872.3, ENSMMUT00000023376.4

Conserved Domains (4) summary

smart00717
Location:489 → 538

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

cd11660
Location:490 → 538

SANT_TRF; Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family

cd00280
Location:87 → 286

TRFH; Telomeric Repeat binding Factor or TTAGGG Repeat binding Factor, central (dimerization) domain Homology; TRFH. Telomeres are protein/DNA complexes that make up the physical ends of eukaryotic linear chromosomes and are essential for chromosome stability, ...

pfam16772
Location:318 → 358

TERF2_RBM; Telomeric repeat-binding factor 2 Rap1-binding motif
XM_015126500.2 → XP_014981986.1 telomeric repeat-binding factor 2 isoform X3

UniProtKB/TrEMBL

I2CTL7

Conserved Domains (4) summary

smart00717
Location:411 → 460

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

cd11660
Location:412 → 460

SANT_TRF; Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family

pfam16772
Location:240 → 280

TERF2_RBM; Telomeric repeat-binding factor 2 Rap1-binding motif

cl02779
Location:87 → 202

TRFH; Telomeric Repeat binding Factor or TTAGGG Repeat binding Factor, central (dimerization) domain Homology; TRFH. Telomeres are protein/DNA complexes that make up the physical ends of eukaryotic linear chromosomes and are essential for chromosome stability, ...