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CREBBP CREB binding protein [ Macaca mulatta (Rhesus monkey) ]

Gene ID: 704331, updated on 17-Aug-2024

Summary

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Official Symbol
CREBBPprovided by VGNC
Official Full Name
CREB binding proteinprovided by VGNC
Primary source
VGNC:VGNC:71487
See related
Ensembl:ENSMMUG00000002286
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Macaca mulatta
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs
human mouse all
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Genomic context

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See CREBBP in Genome Data Viewer
Location:
chromosome: 20
Exon count:
32
Annotation release Status Assembly Chr Location
103 current Mmul_10 (GCF_003339765.1) 20 NC_041773.1 (3769928..3927444, complement)
102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 20 NC_027912.1 (3070125..3228329)

Chromosome 20 - NC_041773.1Genomic Context describing neighboring genes Neighboring gene SLX4 structure-specific endonuclease subunit Neighboring gene deoxyribonuclease 1 Neighboring gene TNF receptor associated protein 1 Neighboring gene uncharacterized LOC114674401 Neighboring gene uncharacterized LOC114674338

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables chromatin DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables histone acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables transcription coactivator activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of histone acetyltransferase complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of transcription regulator complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
CREB-binding protein
NP_001247644.1
XP_014980893.1
XP_014980894.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001260715.1 → NP_001247644.1  CREB-binding protein

    See identical proteins and their annotated locations for NP_001247644.1

    Status: PROVISIONAL

    Source sequence(s)
    JV046228
    UniProtKB/TrEMBL
    A0A5F7ZKK8, F6RRA8, F7B3F8
    Related
    ENSMMUP00000065708.1, ENSMMUT00000093046.1
    Conserved Domains (11) summary
    cd05495
    Location:1087 → 1194
    Bromo_cbp_like; Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to ...
    smart00551
    Location:1766 → 1844
    ZnF_TAZ; TAZ zinc finger, present in p300 and CBP
    COG3416
    Location:861 → 923
    COG3416; Uncharacterized protein [Function unknown]
    cd02337
    Location:1705 → 1745
    ZZ_CBP; Zinc finger, ZZ type. Zinc finger present in CBP/p300 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. CREB-binding protein (CBP) is a large multidomain protein that ...
    pfam09606
    Location:1960 → 2413
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd15802
    Location:1206 → 1278
    RING_CBP-p300; atypical RING domain found in CREB-binding protein and p300 histone acetyltransferases
    cd15557
    Location:1280 → 1311
    PHD_CBP_p300; PHD finger found in CREB-binding protein (CBP) and histone acetyltransferase p300
    pfam02135
    Location:363 → 430
    zf-TAZ; TAZ zinc finger
    pfam02172
    Location:587 → 667
    KIX; KIX domain
    pfam08214
    Location:1342 → 1649
    HAT_KAT11; Histone acetylation protein
    pfam09030
    Location:2034 → 2111
    Creb_binding; Creb binding

RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

  1. NC_041773.1 Reference Mmul_10 Primary Assembly

    Range
    3769928..3927444 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015125408.2 → XP_014980894.1  CREB-binding protein isoform X2

    UniProtKB/TrEMBL
    F6RRA8, F7B3F8
    Conserved Domains (11) summary
    cd05495
    Location:821 → 928
    Bromo_cbp_like; Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to ...
    smart00551
    Location:1500 → 1578
    ZnF_TAZ; TAZ zinc finger, present in p300 and CBP
    COG3416
    Location:595 → 657
    COG3416; Uncharacterized protein [Function unknown]
    cd02337
    Location:1439 → 1479
    ZZ_CBP; Zinc finger, ZZ type. Zinc finger present in CBP/p300 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. CREB-binding protein (CBP) is a large multidomain protein that ...
    pfam09606
    Location:1694 → 2147
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd15802
    Location:940 → 1012
    RING_CBP-p300; atypical RING domain found in CREB-binding protein and p300 histone acetyltransferases
    cd15557
    Location:1014 → 1045
    PHD_CBP_p300; PHD finger found in CREB-binding protein (CBP) and histone acetyltransferase p300
    pfam02135
    Location:97 → 164
    zf-TAZ; TAZ zinc finger
    pfam02172
    Location:321 → 401
    KIX; KIX domain
    pfam08214
    Location:1076 → 1383
    HAT_KAT11; Histone acetylation protein
    pfam09030
    Location:1768 → 1845
    Creb_binding; Creb binding

  2. XM_015125407.2 → XP_014980893.1  CREB-binding protein isoform X1

    UniProtKB/TrEMBL
    A0A5F8ARC8, F6RRA8, F7B3F8
    Related
    ENSMMUP00000080407.1, ENSMMUT00000082550.1
    Conserved Domains (11) summary
    cd05495
    Location:1049 → 1156
    Bromo_cbp_like; Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to ...
    smart00551
    Location:1728 → 1806
    ZnF_TAZ; TAZ zinc finger, present in p300 and CBP
    COG3416
    Location:823 → 885
    COG3416; Uncharacterized protein [Function unknown]
    cd02337
    Location:1667 → 1707
    ZZ_CBP; Zinc finger, ZZ type. Zinc finger present in CBP/p300 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. CREB-binding protein (CBP) is a large multidomain protein that ...
    pfam09606
    Location:1922 → 2375
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd15802
    Location:1168 → 1240
    RING_CBP-p300; atypical RING domain found in CREB-binding protein and p300 histone acetyltransferases
    cd15557
    Location:1242 → 1273
    PHD_CBP_p300; PHD finger found in CREB-binding protein (CBP) and histone acetyltransferase p300
    pfam02135
    Location:363 → 405
    zf-TAZ; TAZ zinc finger
    pfam02172
    Location:549 → 629
    KIX; KIX domain
    pfam08214
    Location:1304 → 1611
    HAT_KAT11; Histone acetylation protein
    pfam09030
    Location:1996 → 2073
    Creb_binding; Creb binding
Nucleotide Protein
Heading Accession and Version

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