ATF4 activating transcription factor 4 [Macaca mulatta (Rhesus monkey)] - Gene

Summary

Official Symbol: ATF4provided by VGNC
Official Full Name: activating transcription factor 4provided by VGNC
Primary source: VGNC:VGNC:107770
See related: Ensembl:ENSMMUG00000055780
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Macaca mulatta
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Annotation information: Annotation category: partial on reference assembly
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 10

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
103	current	Mmul_10 (GCF_003339765.1)	10	NC_041763.1 (12022095..12024008, complement)
102	previous assembly	Mmul_8.0.1 (GCF_000772875.2)	10	NC_027902.1 (81519289..81521200)

Chromosome 10 - NC_041763.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV/SIV exploits the early host antiviral response through GCN2-ATF4 signaling by utilizing ATF4 for activating the viral LTR transcription to establish initial viral replication
Title: HIV Exploits Antiviral Host Innate GCN2-ATF4 Signaling for Establishing Viral Replication Early in Infection.

Submit: New GeneRIF Correction

General gene information

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Markers

SGC30687 (e-PCR)
- UniSTS:2629

RH138 (e-PCR)
- UniSTS:84864

ATF4_4333 (e-PCR)
- UniSTS:462753

RH71390 (e-PCR)
- UniSTS:14034

G20660 (e-PCR)
- UniSTS:62937

A006A38 (e-PCR)
- UniSTS:62938

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info	PubMed
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
part_of ATF1-ATF4 transcription factor complex	IEA Inferred from Electronic Annotation more info	PubMed
part_of ATF4-CREB1 transcription factor complex	IEA Inferred from Electronic Annotation more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: cyclic AMP-dependent transcription factor ATF-4

Names: activating transcription factor 4 (tax-responsive enhancer element B67)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001266632.2 → NP_001253561.1 cyclic AMP-dependent transcription factor ATF-4

Status: PROVISIONAL

Source sequence(s)

JV636171

UniProtKB/TrEMBL

A0A5F8A8K6, F7GFP2, H9EV56, I0FRY7

Related

ENSMMUP00000069353.1, ENSMMUT00000107183.1

Conserved Domains (1) summary

cd14692
Location:279 → 341

bZIP_ATF4; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-4 (ATF-4) and similar proteins: a DNA-binding and dimerization domain