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TGFBR2 transforming growth factor beta receptor 2 [ Macaca mulatta (Rhesus monkey) ]

Gene ID: 703088, updated on 17-Aug-2024

Summary

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Official Symbol
TGFBR2provided by VGNC
Official Full Name
transforming growth factor beta receptor 2provided by VGNC
Primary source
VGNC:VGNC:78338
See related
Ensembl:ENSMMUG00000010031
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Macaca mulatta
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs
human mouse all
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Genomic context

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See TGFBR2 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
9
Annotation release Status Assembly Chr Location
103 current Mmul_10 (GCF_003339765.1) 2 NC_041755.1 (17035106..17123221, complement)
102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 2 NC_027894.1 (190441251..190529470, complement)

Chromosome 2 - NC_041755.1Genomic Context describing neighboring genes Neighboring gene glutamate decarboxylase like 1 Neighboring gene uncharacterized LOC114676225 Neighboring gene uncharacterized LOC106997160 Neighboring gene uncharacterized LOC106997161

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Suppression of transforming growth factor β receptor 2 and Smad5 is associated with high levels of microRNA miR-155 in the oral mucosa during chronic simian immunodeficiency virus infection. George J, et al. J Virol, 2015 Mar. PMID 25540365, Free PMC Article
  2. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
  3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Expression of microRNA miR-155 was significantly upregulated in the oropharyngeal mucosa during chronic SIV infection and was coincident with downregulation of TGFbeta receptor 2 (TGFbeta-R2) and SMAD5.
    Title: Suppression of transforming growth factor β receptor 2 and Smad5 is associated with high levels of microRNA miR-155 in the oral mucosa during chronic simian immunodeficiency virus infection.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables SMAD binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables activin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables activin receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables transforming growth factor beta binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables transforming growth factor beta receptor activity, type II IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables type I transforming growth factor beta receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to growth factor stimulus IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in heart development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in transforming growth factor beta receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of receptor complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
TGF-beta receptor type-2
Names
transforming growth factor, beta receptor II (70/80kDa)
NP_001248080.1
XP_014987809.1
XP_014987810.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001261151.1 → NP_001248080.1  TGF-beta receptor type-2 precursor

    See identical proteins and their annotated locations for NP_001248080.1

    Status: PROVISIONAL

    Source sequence(s)
    JV043253
    UniProtKB/TrEMBL
    A0A1D5RJL2, G8F1I4, H9YUL0
    Related
    ENSMMUP00000060506.2, ENSMMUT00000063908.2
    Conserved Domains (3) summary
    smart00221
    Location:244 → 544
    STYKc; Protein kinase; unclassified specificity
    cd14055
    Location:248 → 542
    STKc_TGFbR2_like; Catalytic domain of the Serine/Threonine Kinase, Transforming Growth Factor beta Type II Receptor
    pfam08917
    Location:49 → 152
    ecTbetaR2; Transforming growth factor beta receptor 2 ectodomain

RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

  1. NC_041755.1 Reference Mmul_10 Primary Assembly

    Range
    17035106..17123221 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015132323.2 → XP_014987809.1  TGF-beta receptor type-2 isoform X1

    UniProtKB/TrEMBL
    F6Q1B1, G8F1I4
    Related
    ENSMMUP00000013111.3, ENSMMUT00000014002.4
    Conserved Domains (3) summary
    smart00221
    Location:269 → 569
    STYKc; Protein kinase; unclassified specificity
    cd14055
    Location:273 → 567
    STKc_TGFbR2_like; Catalytic domain of the Serine/Threonine Kinase, Transforming Growth Factor beta Type II Receptor
    pfam08917
    Location:74 → 177
    ecTbetaR2; Transforming growth factor beta receptor 2 ectodomain

  2. XM_015132324.2 → XP_014987810.1  TGF-beta receptor type-2 isoform X2

    UniProtKB/TrEMBL
    G8F1I4
    Conserved Domains (3) summary
    smart00221
    Location:221 → 521
    STYKc; Protein kinase; unclassified specificity
    cd14055
    Location:225 → 519
    STKc_TGFbR2_like; Catalytic domain of the Serine/Threonine Kinase, Transforming Growth Factor beta Type II Receptor
    pfam08917
    Location:26 → 129
    ecTbetaR2; Transforming growth factor beta receptor 2 ectodomain
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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