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ARAP3 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 [ Macaca mulatta (Rhesus monkey) ]

Gene ID: 701400, updated on 17-Aug-2024

Summary

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Official Symbol
ARAP3provided by VGNC
Official Full Name
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3provided by VGNC
Primary source
VGNC:VGNC:69893
See related
Ensembl:ENSMMUG00000000465
Gene type
protein coding
RefSeq status
MODEL
Organism
Macaca mulatta
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs
human mouse all
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Genomic context

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See ARAP3 in Genome Data Viewer
Location:
chromosome: 6
Exon count:
33
Annotation release Status Assembly Chr Location
103 current Mmul_10 (GCF_003339765.1) 6 NC_041759.1 (139035075..139063578, complement)
102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 6 NC_027898.1 (139428892..139457820, complement)

Chromosome 6 - NC_041759.1Genomic Context describing neighboring genes Neighboring gene histone deacetylase 3 Neighboring gene FCH and double SH3 domains 1 Neighboring gene RELT like 2 Neighboring gene uncharacterized LOC106998972 Neighboring gene protocadherin 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables phosphatidylinositol-3,4,5-trisphosphate binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in ruffle IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

  1. NC_041759.1 Reference Mmul_10 Primary Assembly

    Range
    139035075..139063578 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015141089.2 → XP_014996575.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X4

    UniProtKB/TrEMBL
    G7MVC0
    Conserved Domains (9) summary
    cd09490
    Location:4 → 66
    SAM_Arap1,2,3; SAM domain of Arap1,2,3 (angiotensin receptor-associated protein)
    smart00454
    Location:12 → 64
    SAM; Sterile alpha motif
    cd04385
    Location:853 → 1028
    RhoGAP_ARAP; RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ...
    cd13253
    Location:231 → 323
    PH1_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 1
    cd13254
    Location:340 → 421
    PH2_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 2
    pfam00169
    Location:230 → 321
    PH; PH domain
    pfam00788
    Location:1061 → 1153
    RA; Ras association (RalGDS/AF-6) domain
    pfam01412
    Location:432 → 548
    ArfGap; Putative GTPase activating protein for Arf
    cl17171
    Location:1156 → 1275
    PH-like; Pleckstrin homology-like domain

  2. XM_015141088.2 → XP_014996574.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X3

    UniProtKB/TrEMBL
    A0A1D5RDA8, G7MVC0
    Related
    ENSMMUP00000058301.2, ENSMMUT00000060800.2
    Conserved Domains (9) summary
    cd09490
    Location:4 → 66
    SAM_Arap1,2,3; SAM domain of Arap1,2,3 (angiotensin receptor-associated protein)
    smart00454
    Location:12 → 64
    SAM; Sterile alpha motif
    cd04385
    Location:911 → 1086
    RhoGAP_ARAP; RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ...
    cd13253
    Location:289 → 381
    PH1_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 1
    cd13254
    Location:398 → 479
    PH2_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 2
    pfam00169
    Location:288 → 379
    PH; PH domain
    pfam01412
    Location:490 → 606
    ArfGap; Putative GTPase activating protein for Arf
    cl00155
    Location:1119 → 1203
    UBQ; Ubiquitin-like proteins
    cl17171
    Location:1177 → 1290
    PH-like; Pleckstrin homology-like domain

  3. XM_015141087.2 → XP_014996573.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X2

    UniProtKB/TrEMBL
    F6YQS1
    Related
    ENSMMUP00000000634.4, ENSMMUT00000000685.4
    Conserved Domains (9) summary
    cd09490
    Location:4 → 66
    SAM_Arap1,2,3; SAM domain of Arap1,2,3 (angiotensin receptor-associated protein)
    smart00454
    Location:12 → 64
    SAM; Sterile alpha motif
    cd04385
    Location:911 → 1086
    RhoGAP_ARAP; RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ...
    cd13253
    Location:289 → 381
    PH1_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 1
    cd13254
    Location:398 → 479
    PH2_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 2
    pfam00169
    Location:288 → 379
    PH; PH domain
    pfam00788
    Location:1119 → 1211
    RA; Ras association (RalGDS/AF-6) domain
    pfam01412
    Location:490 → 606
    ArfGap; Putative GTPase activating protein for Arf
    cl17171
    Location:1214 → 1333
    PH-like; Pleckstrin homology-like domain

  4. XM_015141085.2 → XP_014996571.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X1

    UniProtKB/TrEMBL
    A0A1D5QLW8, G7MVC0
    Conserved Domains (9) summary
    cd09490
    Location:4 → 66
    SAM_Arap1,2,3; SAM domain of Arap1,2,3 (angiotensin receptor-associated protein)
    smart00454
    Location:12 → 64
    SAM; Sterile alpha motif
    cd04385
    Location:911 → 1086
    RhoGAP_ARAP; RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ...
    cd13253
    Location:289 → 381
    PH1_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 1
    cd13254
    Location:398 → 479
    PH2_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 2
    pfam00169
    Location:288 → 379
    PH; PH domain
    pfam00788
    Location:1119 → 1211
    RA; Ras association (RalGDS/AF-6) domain
    pfam01412
    Location:490 → 606
    ArfGap; Putative GTPase activating protein for Arf
    cl17171
    Location:1214 → 1333
    PH-like; Pleckstrin homology-like domain

  5. XM_015141090.2 → XP_014996576.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X5

    UniProtKB/TrEMBL
    G7MVC0
    Conserved Domains (7) summary
    cd04385
    Location:833 → 1008
    RhoGAP_ARAP; RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ...
    cd13253
    Location:211 → 303
    PH1_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 1
    cd13254
    Location:320 → 401
    PH2_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 2
    pfam00169
    Location:210 → 301
    PH; PH domain
    pfam00788
    Location:1041 → 1133
    RA; Ras association (RalGDS/AF-6) domain
    pfam01412
    Location:412 → 528
    ArfGap; Putative GTPase activating protein for Arf
    cl17171
    Location:1136 → 1255
    PH-like; Pleckstrin homology-like domain

  6. XM_015141086.2 → XP_014996572.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X1

    UniProtKB/TrEMBL
    A0A1D5QLW8, G7MVC0
    Related
    ENSMMUP00000049043.2, ENSMMUT00000076305.2
    Conserved Domains (9) summary
    cd09490
    Location:4 → 66
    SAM_Arap1,2,3; SAM domain of Arap1,2,3 (angiotensin receptor-associated protein)
    smart00454
    Location:12 → 64
    SAM; Sterile alpha motif
    cd04385
    Location:911 → 1086
    RhoGAP_ARAP; RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ...
    cd13253
    Location:289 → 381
    PH1_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 1
    cd13254
    Location:398 → 479
    PH2_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 2
    pfam00169
    Location:288 → 379
    PH; PH domain
    pfam00788
    Location:1119 → 1211
    RA; Ras association (RalGDS/AF-6) domain
    pfam01412
    Location:490 → 606
    ArfGap; Putative GTPase activating protein for Arf
    cl17171
    Location:1214 → 1333
    PH-like; Pleckstrin homology-like domain
Nucleotide Protein
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