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NLRP3 NLR family pyrin domain containing 3 [ Macaca mulatta (Rhesus monkey) ]

Gene ID: 701278, updated on 14-Nov-2024

Summary

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Official Symbol
NLRP3provided by VGNC
Official Full Name
NLR family pyrin domain containing 3provided by VGNC
Primary source
VGNC:VGNC:75186
See related
Ensembl:ENSMMUG00000005946
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Macaca mulatta
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs
human mouse all
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Genomic context

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See NLRP3 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
11
Annotation release Status Assembly Chr Location
103 current Mmul_10 (GCF_003339765.1) 1 NC_041754.1 (1562863..1596246, complement)
102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 1 NC_027893.1 (224047255..224080212)

Chromosome 1 - NC_041754.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC114678510 Neighboring gene uncharacterized LOC114678532 Neighboring gene NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 pseudogene Neighboring gene olfactory receptor 2B11 Neighboring gene uncharacterized LOC106995270 Neighboring gene zinc finger protein 496

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of oocyte-selective NLRP genes in rhesus macaque monkeys (Macaca mulatta). McDaniel P, et al. Mol Reprod Dev, 2009 Feb. PMID 18509866
  2. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA-binding transcription factor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in inflammatory response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of acute inflammatory response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of non-canonical NF-kappaB signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of NLRP3 inflammasome complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
NACHT, LRR and PYD domains-containing protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001114351.1 → NP_001107823.1  NACHT, LRR and PYD domains-containing protein 3

    See identical proteins and their annotated locations for NP_001107823.1

    Status: PROVISIONAL

    Source sequence(s)
    EU344966
    UniProtKB/Swiss-Prot
    B0FPE9
    UniProtKB/TrEMBL
    G7MFJ4
    Related
    ENSMMUP00000053959.2, ENSMMUT00000074048.2
    Conserved Domains (7) summary
    smart00368
    Location:967 → 994
    LRR_RI; Leucine rich repeat, ribonuclease inhibitor type
    cd00116
    Location:575 → 950
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    cd08320
    Location:10 → 93
    Pyrin_NALPs; Pyrin death domain found in NALP proteins
    sd00033
    Location:742 → 770
    LRR_RI; leucine-rich repeat [structural motif]
    pfam05729
    Location:220 → 389
    NACHT; NACHT domain
    pfam14484
    Location:144 → 210
    FISNA; Fish-specific NACHT associated domain
    pfam17779
    Location:466 → 520
    NOD2_WH; NOD2 winged helix domain

RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

  1. NC_041754.1 Reference Mmul_10 Primary Assembly

    Range
    1562863..1596246 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015127781.2 → XP_014983267.2  NACHT, LRR and PYD domains-containing protein 3 isoform X1

    UniProtKB/TrEMBL
    A0A1D5R0X5, G1K370, G7MFJ4
    Related
    ENSMMUP00000007829.4, ENSMMUT00000008331.4
    Conserved Domains (6) summary
    smart00368
    Location:967 → 994
    LRR_RI; Leucine rich repeat, ribonuclease inhibitor type
    cd00116
    Location:575 → 950
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    cd08320
    Location:10 → 93
    Pyrin_NALPs; Pyrin death domain found in NALP proteins
    sd00033
    Location:742 → 770
    LRR_RI; leucine-rich repeat [structural motif]
    pfam05729
    Location:220 → 389
    NACHT; NACHT domain
    pfam14484
    Location:144 → 209
    FISNA; Fish-specific NACHT associated domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B0FPE9.1 GenPept UniProtKB/Swiss-Prot:B0FPE9

Gene LinkOut

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Research Materials