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Meaf6 MYST/Esa1-associated factor 6 [ Mus musculus (house mouse) ]

Gene ID: 70088, updated on 27-Nov-2024

Summary

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Official Symbol
Meaf6provided by MGI
Official Full Name
MYST/Esa1-associated factor 6provided by MGI
Primary source
MGI:MGI:1917338
See related
Ensembl:ENSMUSG00000028863 AllianceGenome:MGI:1917338
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2310005N01Rik; 2810036M01Rik
Summary
Predicted to contribute to histone acetyltransferase activity. Predicted to be involved in regulation of cell cycle; regulation of cell growth; and regulation of nucleobase-containing compound metabolic process. Predicted to be located in kinetochore; nucleolus; and nucleoplasm. Predicted to be part of MOZ/MORF histone acetyltransferase complex; NuA4 histone acetyltransferase complex; and nucleosome. Orthologous to human MEAF6 (MYST/Esa1 associated factor 6). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in CNS E18 (RPKM 18.5), whole brain E14.5 (RPKM 16.0) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Meaf6 in Genome Data Viewer
Location:
4 D2.2; 4 58.03 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (124978883..125007031)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (125085113..125113238)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6215 Neighboring gene Smad nuclear interacting protein 1 Neighboring gene splicing factor 3a, subunit 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_11351 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:124802021-124802130 Neighboring gene STARR-positive B cell enhancer ABC_E4666 Neighboring gene STARR-positive B cell enhancer ABC_E10258 Neighboring gene zinc finger CCCH type containing 12A Neighboring gene STARR-seq mESC enhancer starr_11354 Neighboring gene STARR-seq mESC enhancer starr_11355 Neighboring gene predicted gene, 40246 Neighboring gene predicted gene, 32611

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. MEAF6 is essential for cell proliferation and plays a role in the assembly of KAT7 complexes. Matsuura K, et al. Exp Cell Res, 2020 Nov 1. PMID 32918898
  2. Hdac6 regulates Tip60-p400 function in stem cells. Chen PB, et al. Elife, 2013 Dec 3. PMID 24302573, Free PMC Article
  3. The TIP60 Complex Regulates Bivalent Chromatin Recognition by 53BP1 through Direct H4K20me Binding and H2AK15 Acetylation. Jacquet K, et al. Mol Cell, 2016 May 5. PMID 27153538, Free PMC Article
  4. Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans. Doyon Y, et al. Mol Cell Biol, 2004 Mar. PMID 14966270, Free PMC Article
  5. ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation. Doyon Y, et al. Mol Cell, 2006 Jan 6. PMID 16387653

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MEAF6 is essential for cell proliferation and plays a role in the assembly of KAT7 complexes.
    Title: MEAF6 is essential for cell proliferation and plays a role in the assembly of KAT7 complexes.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
contributes_to histone H3K14 acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
contributes_to histone H3K14 acetyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
contributes_to histone H4K12 acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
contributes_to histone H4K12 acetyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
contributes_to histone H4K5 acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
contributes_to histone H4K5 acetyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
contributes_to histone H4K8 acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
contributes_to histone H4K8 acetyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA replication ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of apoptotic process NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell growth ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell growth ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of developmental process NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of double-strand break repair NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of hemopoiesis NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of MOZ/MORF histone acetyltransferase complex ISO
Inferred from Sequence Orthology
more info
  
part_of MOZ/MORF histone acetyltransferase complex ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of NuA4 histone acetyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of NuA4 histone acetyltransferase complex ISO
Inferred from Sequence Orthology
more info
  
part_of NuA4 histone acetyltransferase complex ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of histone acetyltransferase complex ISO
Inferred from Sequence Orthology
more info
  
located_in kinetochore ISO
Inferred from Sequence Orthology
more info
  
located_in kinetochore ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
part_of nucleosome ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
chromatin modification-related protein MEAF6
Names
esa1-associated factor 6 homolog
protein EAF6 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290701.2 → NP_001277630.1  chromatin modification-related protein MEAF6 isoform 2

    See identical proteins and their annotated locations for NP_001277630.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate exon in 3' coding region and uses an alternate splice site in the 3' terminal exon, compared to variant 1. It encodes isoform 2, which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK009177, AK012867, AL626775, AW123768, BY133395, BY600332
    Consensus CDS
    CCDS71467.1
    UniProtKB/Swiss-Prot
    B1ASC6, Q2VPQ9, Q9D7J5
    UniProtKB/TrEMBL
    V9GX42
    Related
    ENSMUSP00000122288.2, ENSMUST00000154689.8
    Conserved Domains (1) summary
    pfam09340
    Location:18 → 96
    NuA4; Histone acetyltransferase subunit NuA4

  2. NM_001374123.1 → NP_001361052.1  chromatin modification-related protein MEAF6 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AK012867, AL626775, BQ178199, CO428776
    UniProtKB/TrEMBL
    B1ASC8
    Related
    ENSMUSP00000101777.4, ENSMUST00000106171.9
    Conserved Domains (1) summary
    pfam09340
    Location:18 → 96
    NuA4; Histone acetyltransferase subunit NuA4

  3. NM_027310.5 → NP_081586.1  chromatin modification-related protein MEAF6 isoform 1

    See identical proteins and their annotated locations for NP_081586.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK009177, AK012867, AL626775, AW123768, BY133395, BY600332
    Consensus CDS
    CCDS18637.1
    UniProtKB/TrEMBL
    V9GX42
    Related
    ENSMUSP00000053543.5, ENSMUST00000055213.11
    Conserved Domains (1) summary
    pfam09340
    Location:18 → 96
    NuA4; Histone acetyltransferase subunit NuA4

RNA

  1. NR_151472.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AK012867, AL626775, AW123768, BY133395, BY600332, CX220687

  2. NR_164336.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AK012867, AL626775, BQ178199, CD353468

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    124978883..125007031
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_003955011.2 RNA Sequence

  2. XR_003955012.2 RNA Sequence

  3. XR_004941956.1 RNA Sequence

  4. XR_003955014.2 RNA Sequence

  5. XR_003955013.2 RNA Sequence

  6. XR_004941957.1 RNA Sequence

  7. XR_004941958.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q2VPQ9.1 GenPept UniProtKB/Swiss-Prot:Q2VPQ9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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