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Cysltr2 cysteinyl leukotriene receptor 2 [ Mus musculus (house mouse) ]

Gene ID: 70086, updated on 27-Nov-2024

Summary

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Official Symbol
Cysltr2provided by MGI
Official Full Name
cysteinyl leukotriene receptor 2provided by MGI
Primary source
MGI:MGI:1917336
See related
Ensembl:ENSMUSG00000033470 AllianceGenome:MGI:1917336
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cltr2; Cyslt2; CYSLT2R; 2300001H05Rik
Summary
Enables cysteinyl leukotriene receptor activity. Predicted to be involved in several processes, including negative regulation of glial cell proliferation; neuropeptide signaling pathway; and positive regulation of ERK1 and ERK2 cascade. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Located in membrane. Human ortholog(s) of this gene implicated in aspirin-induced respiratory disease and asthma. Orthologous to human CYSLTR2 (cysteinyl leukotriene receptor 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in thymus adult (RPKM 1.4), spleen adult (RPKM 0.4) and 17 other tissues See more
Orthologs
human all
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Genomic context

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See Cysltr2 in Genome Data Viewer
Location:
14 D3; 14 38.54 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (73263043..73286554, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (73025672..73049114, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:73383337-73383538 Neighboring gene ring finger protein 26 pseudogene Neighboring gene predicted gene, 41208 Neighboring gene glycine cleavage system protein H (aminomethyl carrier) pseudogene Neighboring gene predicted gene, 35388 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:73516811-73517104 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:73518865-73519018 Neighboring gene regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2 Neighboring gene predicted gene, 52109

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cysteinyl leukotriene receptor 2 drives lung immunopathology through a platelet and high mobility box 1-dependent mechanism. Liu T, et al. Mucosal Immunol, 2019 May. PMID 30664709, Free PMC Article
  2. Neutralization of leukotriene C4 and D4 activity by monoclonal and single-chain antibodies. Kawakami Y, et al. Biochim Biophys Acta, 2014 Jun. PMID 24361619
  3. Characterization of the cysteinyl leukotriene 2 receptor in novel expression sites of the gastrointestinal tract. Barajas-Espinosa A, et al. Am J Pathol, 2011 Jun. PMID 21641390, Free PMC Article
  4. The cysteinyl leukotriene 2 receptor mediates retinal edema and pathological neovascularization in a murine model of oxygen-induced retinopathy. Barajas-Espinosa A, et al. FASEB J, 2012 Mar. PMID 22131271
  5. Increased expression of CysLT(2) receptors in the lung of asthmatic mice and role in allergic responses. Matsuda M, et al. Prostaglandins Leukot Essent Fatty Acids, 2018 Apr. PMID 29628047

See all (49) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The CysLT2R receptor mediates leukotriene C4-driven acute and chronic itch.
    Title: The CysLT(2)R receptor mediates leukotriene C(4)-driven acute and chronic itch.
  2. this study shows that cysteinyl leukotriene receptor 2 drives lung immunopathology through a platelet and high mobility box 1-dependent mechanism
    Title: Cysteinyl leukotriene receptor 2 drives lung immunopathology through a platelet and high mobility box 1-dependent mechanism.
  3. CysLT2 receptors were constitutively expressed in the lung, and expression was strengthened in asthmatic mice. Activation of CysLT2 receptors was functionally involved in allergic leukocyte infiltration into the lung.
    Title: Increased expression of CysLT(2) receptors in the lung of asthmatic mice and role in allergic responses.
  4. CysLT2R signaling, IL-33-dependent group 2 innate lymphoid cell expansion, and IL-33-driven mast cell activation are necessary for induction of type 2 immunopathology and aspirin sensitivity. CysLT2R-targeted drugs may interrupt these processes.
    Title: Type 2 Cysteinyl Leukotriene Receptors Drive IL-33-Dependent Type 2 Immunopathology and Aspirin Sensitivity.
  5. It plays a critical role in Ab1e42-induced neurotoxicity.
    Title: Involvement of cysteinyl leukotriene receptor 1 in Aβ1-42-induced neurotoxicity in vitro and in vivo.
  6. The CysLT(1) and CysLT(2) receptors were primarily localized in neurons, microglia and neutrophils
    Title: Aggravated inflammation and increased expression of cysteinyl leukotriene receptors in the brain after focal cerebral ischemia in AQP4-deficient mice.
  7. Suggest that endothelial and nonendothelial CysLT2R niches have separate roles in mediating inflammatory responses in ischemic/perfusion injury.
    Title: Multiple-site activation of the cysteinyl leukotriene receptor 2 is required for exacerbation of ischemia/reperfusion injury.
  8. LTC4 activates mouse platelets exclusively through CysLT2R. LTC4/CysLT2R signaling required an autocrine ADP-mediated response through P2Y12 receptors.
    Title: Cutting edge: Leukotriene C4 activates mouse platelets in plasma exclusively through the type 2 cysteinyl leukotriene receptor.
  9. CysLT1R, CysLT2R and GPR17 might be involved in the MPTP-induced Parkinson disease damage in mice.
    Title: [Expression and distribution of cysteinyl leukotriene receptors CysLT1R and CysLT2R, and GPR17 in brain of Parkinson disease model mice].
  10. CysLT2R negatively regulates the development of cys-LT-dependent T helper cell (Th)2 pulmonary inflammation by inhibiting both CysLT1R signaling and house dust mite-induced LTC4S-dependent cell surface expression of CysLT1R on dendritic cells.
    Title: Cysteinyl leukotriene 2 receptor on dendritic cells negatively regulates ligand-dependent allergic pulmonary inflammation.
Submit: New GeneRIF Correction See all GeneRIFs (16)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled peptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteinyl leukotriene receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteinyl leukotriene receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in cellular response to hypoxia IEA
Inferred from Electronic Annotation
more info
  
involved_in leukotriene signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of glial cell proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of glial cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in neuropeptide signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of ERK1 and ERK2 cascade IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of angiogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cysteinyl leukotriene receptor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001162412.2 → NP_001155884.1  cysteinyl leukotriene receptor 2

    See identical proteins and their annotated locations for NP_001155884.1

    Status: VALIDATED

    Source sequence(s)
    AC155237, CT571265
    Consensus CDS
    CCDS27265.1
    UniProtKB/Swiss-Prot
    A2RT90, Q920A1
    UniProtKB/TrEMBL
    Q8R528
    Related
    ENSMUSP00000125958.2, ENSMUST00000169168.3
    Conserved Domains (2) summary
    cd14964
    Location:25 → 49
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:23 → 300
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  2. NM_133720.4 → NP_598481.2  cysteinyl leukotriene receptor 2

    See identical proteins and their annotated locations for NP_598481.2

    Status: VALIDATED

    Source sequence(s)
    AC155237, CT571265
    Consensus CDS
    CCDS27265.1
    UniProtKB/Swiss-Prot
    A2RT90, Q920A1
    UniProtKB/TrEMBL
    Q8R528
    Related
    ENSMUSP00000040715.5, ENSMUST00000044664.12
    Conserved Domains (2) summary
    cd14964
    Location:25 → 49
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:23 → 300
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    73263043..73286554 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030248001.2 → XP_030103861.1  cysteinyl leukotriene receptor 2 isoform X1

    UniProtKB/Swiss-Prot
    A2RT90, Q920A1
    UniProtKB/TrEMBL
    Q8R528
    Conserved Domains (2) summary
    cd14964
    Location:25 → 49
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:23 → 300
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q920A1.2 GenPept UniProtKB/Swiss-Prot:Q920A1

Gene LinkOut

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