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Tspo2 translocator protein 2 [ Mus musculus (house mouse) ]

Gene ID: 70026, updated on 4-Jan-2025

Summary

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Official Symbol
Tspo2provided by MGI
Official Full Name
translocator protein 2provided by MGI
Primary source
MGI:MGI:1917276
See related
Ensembl:ENSMUSG00000023995 AllianceGenome:MGI:1917276
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Bzrpl1; 2510027D20Rik
Summary
Enables cholesterol binding activity. Involved in enucleate erythrocyte differentiation; intracellular cholesterol transport; and lipid droplet organization. Located in endoplasmic reticulum. Is expressed in several structures, including jaw; liver; skeleton; and spleen. Orthologous to human TSPO2 (translocator protein 2). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in liver E14.5 (RPKM 59.7), liver E14 (RPKM 47.7) and 2 other tissues See more
Orthologs
human all
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Genomic context

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See Tspo2 in Genome Data Viewer
Location:
17 C; 17 24.12 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (48754970..48758592, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (48447942..48451564, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:48549466-48549575 Neighboring gene STARR-positive B cell enhancer ABC_E7541 Neighboring gene STARR-seq mESC enhancer starr_42751 Neighboring gene O-acyl-ADP-ribose deacylase 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:48567545-48567654 Neighboring gene apolipoprotein B mRNA editing enzyme, catalytic polypeptide 2 Neighboring gene predicted gene, 30283 Neighboring gene VISTA enhancer mm243 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:48601436-48601659 Neighboring gene unc-5 family C-terminal like Neighboring gene STARR-seq mESC enhancer starr_42753 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:48649023-48649224 Neighboring gene predicted gene, 30419

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cholesterol-binding protein TSPO2 coordinates maturation and proliferation of terminally differentiating erythroblasts. Kiatpakdee B, et al. J Biol Chem, 2020 Jun 5. PMID 32358067, Free PMC Article
  2. Translocator protein 2 is involved in cholesterol redistribution during erythropoiesis. Fan J, et al. J Biol Chem, 2009 Oct 30. PMID 19729679, Free PMC Article
  3. Mutations in linker-2 of KLF1 impair expression of membrane transporters and cytoskeletal proteins causing hemolysis. Huang S, et al. Nat Commun, 2024 Aug 15. PMID 39147774, Free PMC Article
  4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cholesterol-binding protein TSPO2 coordinates maturation and proliferation of terminally differentiating erythroblasts.
    Title: Cholesterol-binding protein TSPO2 coordinates maturation and proliferation of terminally differentiating erythroblasts.
  2. identify the TSPO2 family of proteins as mediators of cholesterol redistribution-dependent erythroblast maturation during mammalian erythropoiesis
    Title: Translocator protein 2 is involved in cholesterol redistribution during erythropoiesis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Clone Names

  • MGC129410, MGC129411

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 5-aminolevulinic acid transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables 5-aminolevulinic acid transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables cholesterol binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in 5-aminolevulinic acid import across plasma membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in 5-aminolevulinic acid import across plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in enucleate erythrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in import across plasma membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in import across plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in intracellular cholesterol transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lipid droplet organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrial outer membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in organelle membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
translocator protein 2
Names
benzodiazapine receptor, peripheral-like 1
peripheral-type benzodiazepine receptor-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_027292.2 → NP_081568.1  translocator protein 2

    See identical proteins and their annotated locations for NP_081568.1

    Status: PROVISIONAL

    Source sequence(s)
    AK011003
    Consensus CDS
    CCDS28869.1
    UniProtKB/Swiss-Prot
    Q9CRZ8
    UniProtKB/TrEMBL
    E0CX84
    Related
    ENSMUSP00000024794.6, ENSMUST00000024794.12
    Conserved Domains (1) summary
    pfam03073
    Location:10 → 153
    TspO_MBR; TspO/MBR family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    48754970..48758592 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017317631.2 → XP_017173120.1  translocator protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q9CRZ8
    UniProtKB/TrEMBL
    E0CX84
    Conserved Domains (1) summary
    pfam03073
    Location:10 → 153
    TspO_MBR; TspO/MBR family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CRZ8.2 GenPept UniProtKB/Swiss-Prot:Q9CRZ8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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