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HUWE1 HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1 [ Macaca mulatta (Rhesus monkey) ]

Gene ID: 700136, updated on 17-Aug-2024

Summary

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Official Symbol
HUWE1provided by VGNC
Official Full Name
HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1provided by VGNC
Primary source
VGNC:VGNC:73462
See related
Ensembl:ENSMMUG00000006362
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Macaca mulatta
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs
human mouse all
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Genomic context

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See HUWE1 in Genome Data Viewer
Location:
chromosome: X
Exon count:
90
Annotation release Status Assembly Chr Location
103 current Mmul_10 (GCF_003339765.1) X NC_041774.1 (53263348..53417017, complement)
102 previous assembly Mmul_8.0.1 (GCF_000772875.2) X NC_027913.1 (52939857..53092970, complement)

Chromosome X - NC_041774.1Genomic Context describing neighboring genes Neighboring gene hydroxysteroid 17-beta dehydrogenase 10 Neighboring gene TIMELESS-interacting protein pseudogene Neighboring gene microRNA let-7f-2 Neighboring gene microRNA mir-98 Neighboring gene 39S ribosomal protein L32, mitochondrial pseudogene Neighboring gene 28S ribosomal protein S18c, mitochondrial pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ubiquitin-protein transferase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in Golgi organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in membrane fusion IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of protein catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein polyubiquitination IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
E3 ubiquitin-protein ligase HUWE1
Names
HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
NP_001253681.1
XP_014982950.2
XP_028697552.1
XP_028697553.1
XP_028697554.1
XP_028697555.1
XP_028697556.1
XP_028697557.1
XP_028697558.1
XP_028697559.1
XP_028697560.1
XP_028697561.1
XP_028697562.1
XP_028697563.1
XP_028697564.1
XP_028697565.1
XP_028697566.1
XP_028697567.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001266752.1 → NP_001253681.1  E3 ubiquitin-protein ligase HUWE1

    See identical proteins and their annotated locations for NP_001253681.1

    Status: PROVISIONAL

    Source sequence(s)
    JV043380
    UniProtKB/TrEMBL
    F7HBR6, G7NRH6, H9ELS9
    Related
    ENSMMUP00000008397.3, ENSMMUT00000008929.4
    Conserved Domains (7) summary
    cd00078
    Location:4019 → 4372
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14288
    Location:1317 → 1356
    UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
    pfam05466
    Location:2699 → 2916
    BASP1; Brain acid soluble protein 1 (BASP1 protein)
    pfam02825
    Location:1617 → 1678
    WWE; WWE domain
    pfam06012
    Location:92 → 367
    DUF908; Domain of Unknown Function (DUF908)
    pfam06025
    Location:430 → 814
    DUF913; Domain of Unknown Function (DUF913)
    pfam14377
    Location:2968 → 3077
    DUF4414; Domain of unknown function (DUF4414)

RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

  1. NC_041774.1 Reference Mmul_10 Primary Assembly

    Range
    53263348..53417017 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_028841719.1 → XP_028697552.1  E3 ubiquitin-protein ligase HUWE1 isoform X1

    UniProtKB/TrEMBL
    G7NRH6
    Conserved Domains (7) summary
    cd00078
    Location:4100 → 4453
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14288
    Location:1398 → 1437
    UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
    pfam05109
    Location:2803 → 3039
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam02825
    Location:1698 → 1759
    WWE; WWE domain
    pfam06012
    Location:92 → 367
    DUF908; Domain of Unknown Function (DUF908)
    pfam06025
    Location:431 → 895
    DUF913; Domain of Unknown Function (DUF913)
    pfam14377
    Location:3091 → 3122
    DUF4414; Domain of unknown function (DUF4414)

  2. XM_028841728.1 → XP_028697561.1  E3 ubiquitin-protein ligase HUWE1 isoform X1

    UniProtKB/TrEMBL
    G7NRH6
    Conserved Domains (7) summary
    cd00078
    Location:4100 → 4453
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14288
    Location:1398 → 1437
    UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
    pfam05109
    Location:2803 → 3039
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam02825
    Location:1698 → 1759
    WWE; WWE domain
    pfam06012
    Location:92 → 367
    DUF908; Domain of Unknown Function (DUF908)
    pfam06025
    Location:431 → 895
    DUF913; Domain of Unknown Function (DUF913)
    pfam14377
    Location:3091 → 3122
    DUF4414; Domain of unknown function (DUF4414)

  3. XM_028841733.1 → XP_028697566.1  E3 ubiquitin-protein ligase HUWE1 isoform X6

    UniProtKB/TrEMBL
    F7HBR6, G7NRH6, H9ELS9
    Conserved Domains (7) summary
    cd00078
    Location:4019 → 4372
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14288
    Location:1317 → 1356
    UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
    pfam05466
    Location:2699 → 2916
    BASP1; Brain acid soluble protein 1 (BASP1 protein)
    pfam02825
    Location:1617 → 1678
    WWE; WWE domain
    pfam06012
    Location:92 → 367
    DUF908; Domain of Unknown Function (DUF908)
    pfam06025
    Location:430 → 814
    DUF913; Domain of Unknown Function (DUF913)
    pfam14377
    Location:2968 → 3077
    DUF4414; Domain of unknown function (DUF4414)

  4. XM_028841729.1 → XP_028697562.1  E3 ubiquitin-protein ligase HUWE1 isoform X2

    UniProtKB/TrEMBL
    G7NRH6
    Conserved Domains (7) summary
    cd00078
    Location:4099 → 4452
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14288
    Location:1398 → 1437
    UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
    pfam05466
    Location:2779 → 2996
    BASP1; Brain acid soluble protein 1 (BASP1 protein)
    pfam02825
    Location:1698 → 1759
    WWE; WWE domain
    pfam06012
    Location:92 → 367
    DUF908; Domain of Unknown Function (DUF908)
    pfam06025
    Location:430 → 895
    DUF913; Domain of Unknown Function (DUF913)
    pfam14377
    Location:3048 → 3157
    DUF4414; Domain of unknown function (DUF4414)

  5. XM_028841734.1 → XP_028697567.1  E3 ubiquitin-protein ligase HUWE1 isoform X7

    UniProtKB/TrEMBL
    A0A1D5RHP8
    Related
    ENSMMUP00000059842.2, ENSMMUT00000061110.2
    Conserved Domains (7) summary
    cd00078
    Location:3966 → 4319
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14288
    Location:1398 → 1437
    UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
    pfam05466
    Location:2646 → 2863
    BASP1; Brain acid soluble protein 1 (BASP1 protein)
    pfam02825
    Location:1698 → 1759
    WWE; WWE domain
    pfam06012
    Location:92 → 367
    DUF908; Domain of Unknown Function (DUF908)
    pfam06025
    Location:430 → 895
    DUF913; Domain of Unknown Function (DUF913)
    pfam14377
    Location:2915 → 3024
    DUF4414; Domain of unknown function (DUF4414)

  6. XM_028841731.1 → XP_028697564.1  E3 ubiquitin-protein ligase HUWE1 isoform X4

    UniProtKB/TrEMBL
    G7NRH6
    Conserved Domains (7) summary
    PHA03247
    Location:2822 → 3191
    PHA03247; large tegument protein UL36; Provisional
    cd00078
    Location:4084 → 4437
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14288
    Location:1398 → 1437
    UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
    pfam02825
    Location:1698 → 1759
    WWE; WWE domain
    pfam06012
    Location:92 → 367
    DUF908; Domain of Unknown Function (DUF908)
    pfam06025
    Location:430 → 895
    DUF913; Domain of Unknown Function (DUF913)
    pfam14377
    Location:3049 → 3142
    DUF4414; Domain of unknown function (DUF4414)

  7. XM_028841730.1 → XP_028697563.1  E3 ubiquitin-protein ligase HUWE1 isoform X3

    UniProtKB/TrEMBL
    G7NRH6
    Conserved Domains (7) summary
    cd00078
    Location:4085 → 4438
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14288
    Location:1398 → 1437
    UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
    pfam05466
    Location:2780 → 2997
    BASP1; Brain acid soluble protein 1 (BASP1 protein)
    pfam02825
    Location:1698 → 1759
    WWE; WWE domain
    pfam06012
    Location:92 → 367
    DUF908; Domain of Unknown Function (DUF908)
    pfam06025
    Location:430 → 895
    DUF913; Domain of Unknown Function (DUF913)
    pfam14377
    Location:3049 → 3158
    DUF4414; Domain of unknown function (DUF4414)

  8. XM_028841727.1 → XP_028697560.1  E3 ubiquitin-protein ligase HUWE1 isoform X1

    UniProtKB/TrEMBL
    G7NRH6
    Conserved Domains (7) summary
    cd00078
    Location:4100 → 4453
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14288
    Location:1398 → 1437
    UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
    pfam05109
    Location:2803 → 3039
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam02825
    Location:1698 → 1759
    WWE; WWE domain
    pfam06012
    Location:92 → 367
    DUF908; Domain of Unknown Function (DUF908)
    pfam06025
    Location:431 → 895
    DUF913; Domain of Unknown Function (DUF913)
    pfam14377
    Location:3091 → 3122
    DUF4414; Domain of unknown function (DUF4414)

  9. XM_015127464.2 → XP_014982950.2  E3 ubiquitin-protein ligase HUWE1 isoform X1

    UniProtKB/TrEMBL
    G7NRH6
    Conserved Domains (7) summary
    cd00078
    Location:4100 → 4453
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14288
    Location:1398 → 1437
    UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
    pfam05109
    Location:2803 → 3039
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam02825
    Location:1698 → 1759
    WWE; WWE domain
    pfam06012
    Location:92 → 367
    DUF908; Domain of Unknown Function (DUF908)
    pfam06025
    Location:431 → 895
    DUF913; Domain of Unknown Function (DUF913)
    pfam14377
    Location:3091 → 3122
    DUF4414; Domain of unknown function (DUF4414)

  10. XM_028841725.1 → XP_028697558.1  E3 ubiquitin-protein ligase HUWE1 isoform X1

    UniProtKB/TrEMBL
    G7NRH6
    Conserved Domains (7) summary
    cd00078
    Location:4100 → 4453
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14288
    Location:1398 → 1437
    UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
    pfam05109
    Location:2803 → 3039
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam02825
    Location:1698 → 1759
    WWE; WWE domain
    pfam06012
    Location:92 → 367
    DUF908; Domain of Unknown Function (DUF908)
    pfam06025
    Location:431 → 895
    DUF913; Domain of Unknown Function (DUF913)
    pfam14377
    Location:3091 → 3122
    DUF4414; Domain of unknown function (DUF4414)

  11. XM_028841726.1 → XP_028697559.1  E3 ubiquitin-protein ligase HUWE1 isoform X1

    UniProtKB/TrEMBL
    G7NRH6
    Conserved Domains (7) summary
    cd00078
    Location:4100 → 4453
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14288
    Location:1398 → 1437
    UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
    pfam05109
    Location:2803 → 3039
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam02825
    Location:1698 → 1759
    WWE; WWE domain
    pfam06012
    Location:92 → 367
    DUF908; Domain of Unknown Function (DUF908)
    pfam06025
    Location:431 → 895
    DUF913; Domain of Unknown Function (DUF913)
    pfam14377
    Location:3091 → 3122
    DUF4414; Domain of unknown function (DUF4414)

  12. XM_028841724.1 → XP_028697557.1  E3 ubiquitin-protein ligase HUWE1 isoform X1

    UniProtKB/TrEMBL
    G7NRH6
    Conserved Domains (7) summary
    cd00078
    Location:4100 → 4453
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14288
    Location:1398 → 1437
    UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
    pfam05109
    Location:2803 → 3039
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam02825
    Location:1698 → 1759
    WWE; WWE domain
    pfam06012
    Location:92 → 367
    DUF908; Domain of Unknown Function (DUF908)
    pfam06025
    Location:431 → 895
    DUF913; Domain of Unknown Function (DUF913)
    pfam14377
    Location:3091 → 3122
    DUF4414; Domain of unknown function (DUF4414)

  13. XM_028841722.1 → XP_028697555.1  E3 ubiquitin-protein ligase HUWE1 isoform X1

    UniProtKB/TrEMBL
    G7NRH6
    Conserved Domains (7) summary
    cd00078
    Location:4100 → 4453
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14288
    Location:1398 → 1437
    UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
    pfam05109
    Location:2803 → 3039
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam02825
    Location:1698 → 1759
    WWE; WWE domain
    pfam06012
    Location:92 → 367
    DUF908; Domain of Unknown Function (DUF908)
    pfam06025
    Location:431 → 895
    DUF913; Domain of Unknown Function (DUF913)
    pfam14377
    Location:3091 → 3122
    DUF4414; Domain of unknown function (DUF4414)

  14. XM_028841723.1 → XP_028697556.1  E3 ubiquitin-protein ligase HUWE1 isoform X1

    UniProtKB/TrEMBL
    G7NRH6
    Conserved Domains (7) summary
    cd00078
    Location:4100 → 4453
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14288
    Location:1398 → 1437
    UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
    pfam05109
    Location:2803 → 3039
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam02825
    Location:1698 → 1759
    WWE; WWE domain
    pfam06012
    Location:92 → 367
    DUF908; Domain of Unknown Function (DUF908)
    pfam06025
    Location:431 → 895
    DUF913; Domain of Unknown Function (DUF913)
    pfam14377
    Location:3091 → 3122
    DUF4414; Domain of unknown function (DUF4414)

  15. XM_028841720.1 → XP_028697553.1  E3 ubiquitin-protein ligase HUWE1 isoform X1

    UniProtKB/TrEMBL
    G7NRH6
    Conserved Domains (7) summary
    cd00078
    Location:4100 → 4453
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14288
    Location:1398 → 1437
    UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
    pfam05109
    Location:2803 → 3039
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam02825
    Location:1698 → 1759
    WWE; WWE domain
    pfam06012
    Location:92 → 367
    DUF908; Domain of Unknown Function (DUF908)
    pfam06025
    Location:431 → 895
    DUF913; Domain of Unknown Function (DUF913)
    pfam14377
    Location:3091 → 3122
    DUF4414; Domain of unknown function (DUF4414)

  16. XM_028841721.1 → XP_028697554.1  E3 ubiquitin-protein ligase HUWE1 isoform X1

    UniProtKB/TrEMBL
    G7NRH6
    Conserved Domains (7) summary
    cd00078
    Location:4100 → 4453
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14288
    Location:1398 → 1437
    UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
    pfam05109
    Location:2803 → 3039
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam02825
    Location:1698 → 1759
    WWE; WWE domain
    pfam06012
    Location:92 → 367
    DUF908; Domain of Unknown Function (DUF908)
    pfam06025
    Location:431 → 895
    DUF913; Domain of Unknown Function (DUF913)
    pfam14377
    Location:3091 → 3122
    DUF4414; Domain of unknown function (DUF4414)

  17. XM_028841732.1 → XP_028697565.1  E3 ubiquitin-protein ligase HUWE1 isoform X5

    UniProtKB/TrEMBL
    G7NRH6
    Conserved Domains (7) summary
    PHA03247
    Location:2821 → 3190
    PHA03247; large tegument protein UL36; Provisional
    cd00078
    Location:4083 → 4436
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14288
    Location:1398 → 1437
    UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
    pfam02825
    Location:1698 → 1759
    WWE; WWE domain
    pfam06012
    Location:92 → 367
    DUF908; Domain of Unknown Function (DUF908)
    pfam06025
    Location:430 → 895
    DUF913; Domain of Unknown Function (DUF913)
    pfam14377
    Location:3048 → 3141
    DUF4414; Domain of unknown function (DUF4414)
Nucleotide Protein
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