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PTPN13 protein tyrosine phosphatase non-receptor type 13 [ Macaca mulatta (Rhesus monkey) ]

Gene ID: 699866, updated on 17-Aug-2024

Summary

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Official Symbol
PTPN13provided by VGNC
Official Full Name
protein tyrosine phosphatase non-receptor type 13provided by VGNC
Primary source
VGNC:VGNC:76599
See related
Ensembl:ENSMMUG00000003726
Gene type
protein coding
RefSeq status
MODEL
Organism
Macaca mulatta
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs
human mouse all
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Genomic context

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See PTPN13 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
50
Annotation release Status Assembly Chr Location
103 current Mmul_10 (GCF_003339765.1) 5 NC_041758.1 (84990335..85214752)
102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 5 NC_027897.1 (84939633..85164084)

Chromosome 5 - NC_041758.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC114678348 Neighboring gene uncharacterized LOC106998405 Neighboring gene mitogen-activated protein kinase 6 Neighboring gene solute carrier family 10 member 6 Neighboring gene chromosome 5 C4orf36 homolog Neighboring gene small nuclear ribonucleoprotein G pseudogene Neighboring gene 60S ribosomal protein L6 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables phosphatidylinositol 3-kinase regulatory subunit binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in peptidyl-tyrosine dephosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
tyrosine-protein phosphatase non-receptor type 13
Names
tyrosine-protein phosphatase non-receptor type 13-like

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

  1. NC_041758.1 Reference Mmul_10 Primary Assembly

    Range
    84990335..85214752
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_028848599.1 → XP_028704432.1  tyrosine-protein phosphatase non-receptor type 13 isoform X2

    UniProtKB/TrEMBL
    G7MTC4
    Conserved Domains (8) summary
    smart00228
    Location:1504 → 1595
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    smart00295
    Location:574 → 782
    B41; Band 4.1 homologues
    smart00750
    Location:3 → 190
    KIND; kinase non-catalytic C-lobe domain
    cd00992
    Location:1092 → 1176
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam16599
    Location:1178 → 1368
    PTN13_u3; Unstructured linker region on PTN13 protein between PDZ
    cd17195
    Location:572 → 667
    FERM_F1_PTPN13; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in tyrosine-protein phosphatase non-receptor type 13 (PTPN13)
    cd14597
    Location:2259 → 2492
    PTPc-N13; catalytic domain of tyrosine-protein phosphatase non-receptor type 13
    cl17171
    Location:778 → 878
    PH-like; Pleckstrin homology-like domain

  2. XM_002808414.3 → XP_002808460.2  tyrosine-protein phosphatase non-receptor type 13 isoform X3

    UniProtKB/TrEMBL
    F6S1D8, G7MTC4
    Related
    ENSMMUP00000004975.4, ENSMMUT00000005281.4
    Conserved Domains (10) summary
    smart00194
    Location:2221 → 2473
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00228
    Location:1504 → 1595
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    smart00295
    Location:574 → 782
    B41; Band 4.1 homologues
    smart00750
    Location:3 → 190
    KIND; kinase non-catalytic C-lobe domain
    cd00047
    Location:2247 → 2473
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00992
    Location:1092 → 1176
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00373
    Location:669 → 782
    FERM_M; FERM central domain
    pfam09379
    Location:577 → 639
    FERM_N; FERM N-terminal domain
    pfam16599
    Location:1178 → 1368
    PTN13_u3; Unstructured linker region on PTN13 protein between PDZ
    cl17171
    Location:778 → 878
    PH-like; Pleckstrin homology-like domain

  3. XM_015138756.2 → XP_014994242.1  tyrosine-protein phosphatase non-receptor type 13 isoform X5

    UniProtKB/TrEMBL
    G7MTC4
    Conserved Domains (10) summary
    smart00194
    Location:2197 → 2449
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00228
    Location:1480 → 1571
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    smart00295
    Location:574 → 782
    B41; Band 4.1 homologues
    smart00750
    Location:3 → 190
    KIND; kinase non-catalytic C-lobe domain
    cd00047
    Location:2223 → 2449
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00992
    Location:1073 → 1157
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00373
    Location:669 → 782
    FERM_M; FERM central domain
    pfam09379
    Location:577 → 639
    FERM_N; FERM N-terminal domain
    pfam16599
    Location:1159 → 1349
    PTN13_u3; Unstructured linker region on PTN13 protein between PDZ
    cl17171
    Location:778 → 878
    PH-like; Pleckstrin homology-like domain

  4. XM_028848600.1 → XP_028704433.1  tyrosine-protein phosphatase non-receptor type 13 isoform X6

    UniProtKB/TrEMBL
    G7MTC4
    Conserved Domains (8) summary
    smart00228
    Location:1308 → 1399
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    smart00295
    Location:574 → 782
    B41; Band 4.1 homologues
    smart00750
    Location:3 → 190
    KIND; kinase non-catalytic C-lobe domain
    cd00992
    Location:901 → 985
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam16599
    Location:987 → 1177
    PTN13_u3; Unstructured linker region on PTN13 protein between PDZ
    cd17195
    Location:572 → 667
    FERM_F1_PTPN13; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in tyrosine-protein phosphatase non-receptor type 13 (PTPN13)
    cd14597
    Location:2046 → 2279
    PTPc-N13; catalytic domain of tyrosine-protein phosphatase non-receptor type 13
    cl17171
    Location:778 → 878
    PH-like; Pleckstrin homology-like domain

  5. XM_015138755.2 → XP_014994241.1  tyrosine-protein phosphatase non-receptor type 13 isoform X4

    UniProtKB/TrEMBL
    G7MTC4
    Conserved Domains (10) summary
    smart00194
    Location:2216 → 2468
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00228
    Location:1499 → 1590
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    smart00295
    Location:574 → 782
    B41; Band 4.1 homologues
    smart00750
    Location:3 → 190
    KIND; kinase non-catalytic C-lobe domain
    cd00047
    Location:2242 → 2468
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00992
    Location:1092 → 1176
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00373
    Location:669 → 782
    FERM_M; FERM central domain
    pfam09379
    Location:577 → 639
    FERM_N; FERM N-terminal domain
    pfam16599
    Location:1178 → 1368
    PTN13_u3; Unstructured linker region on PTN13 protein between PDZ
    cl17171
    Location:778 → 878
    PH-like; Pleckstrin homology-like domain

  6. XM_028848597.1 → XP_028704430.1  tyrosine-protein phosphatase non-receptor type 13 isoform X1

    UniProtKB/TrEMBL
    G7MTC4
    Conserved Domains (8) summary
    smart00228
    Location:1508 → 1599
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    smart00295
    Location:583 → 791
    B41; Band 4.1 homologues
    smart00750
    Location:12 → 199
    KIND; kinase non-catalytic C-lobe domain
    cd00992
    Location:1101 → 1185
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam16599
    Location:1187 → 1377
    PTN13_u3; Unstructured linker region on PTN13 protein between PDZ
    cd17195
    Location:581 → 676
    FERM_F1_PTPN13; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in tyrosine-protein phosphatase non-receptor type 13 (PTPN13)
    cd14597
    Location:2263 → 2496
    PTPc-N13; catalytic domain of tyrosine-protein phosphatase non-receptor type 13
    cl17171
    Location:787 → 887
    PH-like; Pleckstrin homology-like domain

  7. XM_028848598.1 → XP_028704431.1  tyrosine-protein phosphatase non-receptor type 13 isoform X2

    UniProtKB/TrEMBL
    G7MTC4
    Conserved Domains (8) summary
    smart00228
    Location:1504 → 1595
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    smart00295
    Location:574 → 782
    B41; Band 4.1 homologues
    smart00750
    Location:3 → 190
    KIND; kinase non-catalytic C-lobe domain
    cd00992
    Location:1092 → 1176
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam16599
    Location:1178 → 1368
    PTN13_u3; Unstructured linker region on PTN13 protein between PDZ
    cd17195
    Location:572 → 667
    FERM_F1_PTPN13; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in tyrosine-protein phosphatase non-receptor type 13 (PTPN13)
    cd14597
    Location:2259 → 2492
    PTPc-N13; catalytic domain of tyrosine-protein phosphatase non-receptor type 13
    cl17171
    Location:778 → 878
    PH-like; Pleckstrin homology-like domain
Nucleotide Protein
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