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TJP2 tight junction protein 2 [ Macaca mulatta (Rhesus monkey) ]

Gene ID: 699586, updated on 17-Aug-2024

Summary

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Official Symbol
TJP2provided by VGNC
Official Full Name
tight junction protein 2provided by VGNC
Primary source
VGNC:VGNC:112121
See related
Ensembl:ENSMMUG00000003780
Gene type
protein coding
RefSeq status
MODEL
Organism
Macaca mulatta
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs
human mouse all
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Genomic context

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See TJP2 in Genome Data Viewer
Location:
chromosome: 15
Exon count:
26
Annotation release Status Assembly Chr Location
103 current Mmul_10 (GCF_003339765.1) 15 NC_041768.1 (84575055..84714613)
102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 15 NC_027907.1 (85328688..85469531)

Chromosome 15 - NC_041768.1Genomic Context describing neighboring genes Neighboring gene protein kinase cAMP-activated catalytic subunit gamma Neighboring gene frataxin Neighboring gene endosomal transmembrane epsin interactor 1 Neighboring gene uncharacterized LOC114672808 Neighboring gene uncharacterized LOC114672810 Neighboring gene amyloid beta precursor protein binding family A member 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables cell adhesion molecule binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell-cell junction organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in establishment of endothelial intestinal barrier IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of blood-brain barrier permeability IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein localization to cell-cell junction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in bicellular tight junction IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
tight junction protein ZO-2
Names
tight junction protein ZO-2-like

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

  1. NC_041768.1 Reference Mmul_10 Primary Assembly

    Range
    84575055..84714613
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015117863.2 → XP_014973349.1  tight junction protein ZO-2 isoform X7

    UniProtKB/TrEMBL
    I2CXW9
    Conserved Domains (7) summary
    cd12027
    Location:579 → 641
    SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2
    smart00072
    Location:675 → 854
    GuKc; Guanylate kinase homologues
    COG0265
    Location:277 → 367
    DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
    cd00992
    Location:9 → 94
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00595
    Location:274 → 357
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam08648
    Location:126 → 237
    DUF1777; Protein of unknown function (DUF1777)
    pfam12871
    Location:118 → 197
    PRP38_assoc; Pre-mRNA-splicing factor 38-associated hydrophilic C-term

  2. XM_015117858.2 → XP_014973344.2  tight junction protein ZO-2 isoform X3

    UniProtKB/TrEMBL
    A0A1D5Q924, I2CXW8
    Related
    ENSMMUP00000044542.2, ENSMMUT00000065139.2
    Conserved Domains (6) summary
    cd12027
    Location:579 → 641
    SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2
    smart00072
    Location:675 → 854
    GuKc; Guanylate kinase homologues
    cd00992
    Location:9 → 94
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    TIGR01622
    Location:160 → 274
    SF-CC1; splicing factor, CC1-like family
    TIGR01642
    Location:121 → 203
    U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
    pfam00595
    Location:274 → 357
    PDZ; PDZ domain (Also known as DHR or GLGF)

  3. XM_015117862.2 → XP_014973348.1  tight junction protein ZO-2 isoform X6

    UniProtKB/TrEMBL
    F7GVN1, I2CXW9
    Related
    ENSMMUP00000005040.4, ENSMMUT00000005352.4
    Conserved Domains (6) summary
    cd12027
    Location:602 → 664
    SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2
    smart00072
    Location:698 → 877
    GuKc; Guanylate kinase homologues
    cd00992
    Location:32 → 117
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    TIGR01622
    Location:183 → 297
    SF-CC1; splicing factor, CC1-like family
    TIGR01642
    Location:144 → 226
    U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
    pfam00595
    Location:297 → 380
    PDZ; PDZ domain (Also known as DHR or GLGF)

  4. XM_015117857.2 → XP_014973343.2  tight junction protein ZO-2 isoform X2

    UniProtKB/TrEMBL
    H9G213, I2CXW8
    Conserved Domains (6) summary
    cd12027
    Location:602 → 664
    SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2
    smart00072
    Location:698 → 877
    GuKc; Guanylate kinase homologues
    cd00992
    Location:32 → 117
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    TIGR01622
    Location:183 → 297
    SF-CC1; splicing factor, CC1-like family
    TIGR01642
    Location:144 → 226
    U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
    pfam00595
    Location:297 → 380
    PDZ; PDZ domain (Also known as DHR or GLGF)

  5. XM_015117855.2 → XP_014973341.2  tight junction protein ZO-2 isoform X1

    UniProtKB/TrEMBL
    A0A1D5QPT5, H9G212
    Related
    ENSMMUP00000050062.2, ENSMMUT00000057863.2
    Conserved Domains (6) summary
    cd12027
    Location:606 → 668
    SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2
    smart00072
    Location:702 → 881
    GuKc; Guanylate kinase homologues
    cd00992
    Location:36 → 121
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    TIGR01622
    Location:187 → 301
    SF-CC1; splicing factor, CC1-like family
    TIGR01642
    Location:148 → 230
    U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
    pfam00595
    Location:301 → 384
    PDZ; PDZ domain (Also known as DHR or GLGF)

  6. XM_015117861.2 → XP_014973347.1  tight junction protein ZO-2 isoform X5

    UniProtKB/TrEMBL
    A0A1D5QPT5, A0A5F7ZAY2
    Related
    ENSMMUP00000062339.1, ENSMMUT00000108180.1
    Conserved Domains (7) summary
    cd12027
    Location:606 → 668
    SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2
    smart00072
    Location:702 → 881
    GuKc; Guanylate kinase homologues
    COG0265
    Location:304 → 394
    DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
    cd00992
    Location:36 → 121
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00595
    Location:301 → 384
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam08648
    Location:153 → 264
    DUF1777; Protein of unknown function (DUF1777)
    pfam12871
    Location:145 → 224
    PRP38_assoc; Pre-mRNA-splicing factor 38-associated hydrophilic C-term

  7. XM_015117860.2 → XP_014973346.2  tight junction protein ZO-2 isoform X4

    UniProtKB/TrEMBL
    A0A1D5QPT5, F7F8F4, H9G215
    Related
    ENSMMUP00000009026.4, ENSMMUT00000009605.4
    Conserved Domains (6) summary
    cd12027
    Location:606 → 668
    SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2
    smart00072
    Location:702 → 881
    GuKc; Guanylate kinase homologues
    cd00992
    Location:36 → 121
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    TIGR01622
    Location:187 → 301
    SF-CC1; splicing factor, CC1-like family
    TIGR01642
    Location:148 → 230
    U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
    pfam00595
    Location:301 → 384
    PDZ; PDZ domain (Also known as DHR or GLGF)
Nucleotide Protein
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