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NEDD4 NEDD4 E3 ubiquitin protein ligase [ Macaca mulatta (Rhesus monkey) ]

Gene ID: 699550, updated on 17-Aug-2024

Summary

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Official Symbol
NEDD4provided by VGNC
Official Full Name
NEDD4 E3 ubiquitin protein ligaseprovided by VGNC
Primary source
VGNC:VGNC:75302
See related
Ensembl:ENSMMUG00000008112
Gene type
protein coding
RefSeq status
MODEL
Organism
Macaca mulatta
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs
human mouse all
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Genomic context

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See NEDD4 in Genome Data Viewer
Location:
chromosome: 7
Exon count:
30
Annotation release Status Assembly Chr Location
103 current Mmul_10 (GCF_003339765.1) 7 NC_041760.1 (32214341..32381330, complement)
102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 7 NC_027899.1 (32289892..32456925, complement)

Chromosome 7 - NC_041760.1Genomic Context describing neighboring genes Neighboring gene pygopus family PHD finger 1 Neighboring gene protogenin Neighboring gene POU domain, class 5, transcription factor 3-like Neighboring gene small nucleolar RNA U13 Neighboring gene uncharacterized LOC114679412 Neighboring gene regulatory factor X7 Neighboring gene hydroxyacyl-coenzyme A dehydrogenase, mitochondrial pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables sodium channel inhibitor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of sodium ion transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in neuromuscular junction development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in receptor catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in receptor internalization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of dendrite morphogenesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
E3 ubiquitin-protein ligase NEDD4
Names
neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
XP_001088005.4
XP_014997786.2
XP_014997787.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

  1. NC_041760.1 Reference Mmul_10 Primary Assembly

    Range
    32214341..32381330 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015142301.2 → XP_014997787.1  E3 ubiquitin-protein ligase NEDD4 isoform X3

    UniProtKB/TrEMBL
    F7HIT1, H9FUU5
    Related
    ENSMMUP00000010623.3, ENSMMUT00000011335.4
    Conserved Domains (4) summary
    cd04033
    Location:20 → 151
    C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
    smart00456
    Location:474 → 506
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:567 → 896
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    pfam00397
    Location:350 → 379
    WW; WW domain

  2. XM_001088005.4 → XP_001088005.4  E3 ubiquitin-protein ligase NEDD4 isoform X1

    UniProtKB/TrEMBL
    A0A5F8A505, G7MXI5
    Related
    ENSMMUP00000073029.1, ENSMMUT00000106165.1
    Conserved Domains (5) summary
    smart00456
    Location:893 → 925
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:986 → 1315
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00201
    Location:843 → 873
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    pfam00397
    Location:769 → 798
    WW; WW domain
    cl14603
    Location:517 → 570
    C2; C2 domain

  3. XM_015142300.2 → XP_014997786.2  E3 ubiquitin-protein ligase NEDD4 isoform X2

    UniProtKB/TrEMBL
    F7GSC9, G7MXI5
    Related
    ENSMMUP00000033590.3, ENSMMUT00000040533.3
    Conserved Domains (5) summary
    smart00456
    Location:876 → 908
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:969 → 1298
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00201
    Location:826 → 856
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    pfam00397
    Location:752 → 781
    WW; WW domain
    cl14603
    Location:513 → 553
    C2; C2 domain
Nucleotide Protein
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