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Tunar Tcl1 upstream neural differentiation associated RNA [ Mus musculus (house mouse) ]

Gene ID: 69952, updated on 4-Jan-2025

Summary

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Official Symbol
Tunarprovided by MGI
Official Full Name
Tcl1 upstream neural differentiation associated RNAprovided by MGI
Primary source
MGI:MGI:1917202
See related
Ensembl:ENSMUSG00000097929 AllianceGenome:MGI:1917202
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
BNLN; Tuna; pTUNAR; Mi-Lnc78; 2810011L19Rik
Summary
Enables ATPase binding activity. Involved in negative regulation of neuron differentiation; neuron projection morphogenesis; and regulation of cytosolic calcium ion concentration. Acts upstream of or within several processes, including neuron fate commitment; positive regulation of mitotic cell cycle; and positive regulation of transcription by RNA polymerase II. Located in endoplasmic reticulum and nucleus. Part of ribonucleoprotein complex. Is expressed in several structures, including central nervous system; eye; pancreas; and reproductive system. Orthologous to human TUNAR (TCL1 upstream neural differentiation-associated RNA). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in cerebellum adult (RPKM 7.4), CNS E18 (RPKM 4.6) and 4 other tissues See more
Orthologs
human all
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Genomic context

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See Tunar in Genome Data Viewer
Location:
12 E; 12 55.45 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (105303087..105350191)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (105336594..105383932)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_33171 Neighboring gene predicted gene, 53762 Neighboring gene predicted gene, 53763 Neighboring gene STARR-seq mESC enhancer starr_33174 Neighboring gene STARR-seq mESC enhancer starr_33176 Neighboring gene STARR-seq mESC enhancer starr_33177 Neighboring gene predicted gene 2721 Neighboring gene RIKEN cDNA D430019H16 gene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. LncRNA Tuna is activated in cadmium-induced placental insufficiency and drives the NRF2-mediated oxidative stress response. Simmers MD, et al. Front Cell Dev Biol, 2023. PMID 37325564, Free PMC Article
  2. TUNAR lncRNA Encodes a Microprotein that Regulates Neural Differentiation and Neurite Formation by Modulating Calcium Dynamics. Senís E, et al. Front Cell Dev Biol, 2021. PMID 35036403, Free PMC Article
  3. An evolutionarily conserved long noncoding RNA TUNA controls pluripotency and neural lineage commitment. Lin N, et al. Mol Cell, 2014 Mar 20. PMID 24530304, Free PMC Article
  4. Human β cell transcriptome analysis uncovers lncRNAs that are tissue-specific, dynamically regulated, and abnormally expressed in type 2 diabetes. Morán I, et al. Cell Metab, 2012 Oct 3. PMID 23040067, Free PMC Article
  5. The Vertebrate Genome Annotation browser 10 years on. Harrow JL, et al. Nucleic Acids Res, 2014 Jan. PMID 24316575, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATPase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ATPase binding ISO
Inferred from Sequence Orthology
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in endoplasmic reticulum calcium ion homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in endoplasmic reticulum calcium ion homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within negative regulation of cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of neuron differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within neuron fate commitment IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuron projection morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of chromatin binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within positive regulation of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of cytosolic calcium ion concentration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of ribonucleoprotein complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
protein TUNAR
Names
beta cell and neural cell-regulin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001416144.1 → NP_001403073.1  protein TUNAR

    Status: VALIDATED

    Source sequence(s)
    AC122013

  2. NM_001416145.1 → NP_001403074.1  protein TUNAR

    Status: VALIDATED

    Source sequence(s)
    AC122013

RNA

  1. NR_183401.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC122013
    Related
    ENSMUST00000180503.3

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    105303087..105350191
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NR_045047.1: Suppressed sequence

    Description
    NR_045047.1: This RefSeq was removed because it is now thought that this gene does encode a protein.

  2. NR_125773.1: Suppressed sequence

    Description
    NR_125773.1: This RefSeq was removed because it is now thought that this gene does encode a protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A1B0GQX2.2 GenPept UniProtKB/Swiss-Prot:A0A1B0GQX2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.