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PROC protein C, inactivator of coagulation factors Va and VIIIa [ Macaca mulatta (Rhesus monkey) ]

Gene ID: 699077, updated on 5-Mar-2024

Summary

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Gene symbol
PROC
Gene description
protein C, inactivator of coagulation factors Va and VIIIa
See related
Ensembl:ENSMMUG00000049035
Gene type
protein coding
RefSeq status
MODEL
Organism
Macaca mulatta
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs
human mouse all
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Genomic context

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See PROC in Genome Data Viewer
Location:
chromosome: 12
Exon count:
9
Annotation release Status Assembly Chr Location
103 current Mmul_10 (GCF_003339765.1) 12 NC_041765.1 (3467320..3478112, complement)
102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 12 NC_027904.1 (3201473..3212735, complement)

Chromosome 12 - NC_041765.1Genomic Context describing neighboring genes Neighboring gene myosin VIIB Neighboring gene interacts with SUPT6H, CTD assembly factor 1 Neighboring gene U4 spliceosomal RNA Neighboring gene uncharacterized LOC114671496 Neighboring gene mitogen-activated protein kinase kinase kinase 2 Neighboring gene U6 spliceosomal RNA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in blood coagulation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
vitamin K-dependent protein C
Names
Anticoagulant protein C
Autoprothrombin IIA
Blood coagulation factor XIV
vitamin K-dependent protein C preproprotein
XP_014965335.1
XP_014965336.1
XP_014965337.1
XP_014965338.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

  1. NC_041765.1 Reference Mmul_10 Primary Assembly

    Range
    3467320..3478112 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015109849.2 → XP_014965335.1  vitamin K-dependent protein C isoform X1

    Conserved Domains (5) summary
    smart00020
    Location:293 → 527
    Tryp_SPc; Trypsin-like serine protease
    smart00069
    Location:116 → 168
    GLA; Domain containing Gla (gamma-carboxyglutamate) residues
    cd00054
    Location:182 → 213
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00190
    Location:295 → 530
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam14670
    Location:221 → 256
    FXa_inhibition; Coagulation Factor Xa inhibitory site

  2. XM_015109850.2 → XP_014965336.1  vitamin K-dependent protein C isoform X2

    UniProtKB/TrEMBL
    A0A1D5QSH6, A0A5F8A509
    Related
    ENSMMUP00000051004.1, ENSMMUT00000065067.2
    Conserved Domains (5) summary
    smart00020
    Location:233 → 467
    Tryp_SPc; Trypsin-like serine protease
    smart00069
    Location:45 → 108
    GLA; Domain containing Gla (gamma-carboxyglutamate) residues
    cd00054
    Location:122 → 153
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00190
    Location:235 → 470
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam14670
    Location:161 → 196
    FXa_inhibition; Coagulation Factor Xa inhibitory site

  3. XM_015109852.2 → XP_014965338.1  vitamin K-dependent protein C isoform X3

    UniProtKB/TrEMBL
    A0A5F8A509
    Conserved Domains (5) summary
    smart00020
    Location:212 → 446
    Tryp_SPc; Trypsin-like serine protease
    smart00069
    Location:24 → 87
    GLA; Domain containing Gla (gamma-carboxyglutamate) residues
    cd00054
    Location:101 → 132
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00190
    Location:214 → 449
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam14670
    Location:140 → 175
    FXa_inhibition; Coagulation Factor Xa inhibitory site

  4. XM_015109851.2 → XP_014965337.1  vitamin K-dependent protein C isoform X4

    Conserved Domains (3) summary
    smart00020
    Location:171 → 405
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:173 → 408
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam14670
    Location:99 → 134
    FXa_inhibition; Coagulation Factor Xa inhibitory site
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q28506.1 GenPept UniProtKB/Swiss-Prot:Q28506

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