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ITSN1 intersectin 1 [ Macaca mulatta (Rhesus monkey) ]

Gene ID: 698606, updated on 17-Aug-2024

Summary

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Official Symbol
ITSN1provided by VGNC
Official Full Name
intersectin 1provided by VGNC
Primary source
VGNC:VGNC:73806
See related
Ensembl:ENSMMUG00000007626
Gene type
protein coding
RefSeq status
MODEL
Organism
Macaca mulatta
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs
human mouse all
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Genomic context

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See ITSN1 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
42
Annotation release Status Assembly Chr Location
103 current Mmul_10 (GCF_003339765.1) 3 NC_041756.1 (12656825..12910771, complement)
102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 3 NC_027895.1 (12802096..13049019, complement)

Chromosome 3 - NC_041756.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC106997267 Neighboring gene ATP synthase peripheral stalk subunit OSCP Neighboring gene crystallin zeta like 1 Neighboring gene DNA replication fork stabilization factor DONSON Neighboring gene SON DNA and RNA binding protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables molecular adaptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in clathrin-dependent synaptic vesicle endocytosis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in endosomal transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of Rho protein signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in clathrin-coated pit IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in intracellular vesicle IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in presynaptic membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
intersectin-1
Names
intersectin 1 (SH3 domain protein)

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

  1. NC_041756.1 Reference Mmul_10 Primary Assembly

    Range
    12656825..12910771 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_028845344.1 → XP_028701177.1  intersectin-1 isoform X2

    UniProtKB/TrEMBL
    A0A1D5Q9V9
    Related
    ENSMMUP00000044827.2, ENSMMUT00000078154.2
    Conserved Domains (12) summary
    cd08375
    Location:1576 → 1710
    C2_Intersectin; C2 domain present in Intersectin
    smart00027
    Location:213 → 308
    EH; Eps15 homology domain
    cd11987
    Location:743 → 797
    SH3_Intersectin1_1; First Src homology 3 domain (or SH3A) of Intersectin-1
    cd11989
    Location:911 → 962
    SH3_Intersectin1_2; Second Src homology 3 domain (or SH3B) of Intersectin-1
    cd11991
    Location:1000 → 1051
    SH3_Intersectin1_3; Third Src homology 3 domain (or SH3C) of Intersectin-1
    cd11993
    Location:1068 → 1132
    SH3_Intersectin1_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-1
    cd11995
    Location:1152 → 1205
    SH3_Intersectin1_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-1
    COG1196
    Location:359 → 687
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00160
    Location:1232 → 1415
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    pfam16617
    Location:797 → 911
    INTAP; Intersectin and clathrin adaptor AP2 binding region
    pfam16652
    Location:1434 → 1576
    PH_13; Pleckstrin homology domain
    NF033761
    Location:95 → 179
    gliding_GltJ; adventurous gliding motility protein GltJ

  2. XM_028845347.1 → XP_028701180.1  intersectin-1 isoform X4

    Conserved Domains (11) summary
    cd08375
    Location:1505 → 1639
    C2_Intersectin; C2 domain present in Intersectin
    smart00027
    Location:213 → 308
    EH; Eps15 homology domain
    cd11987
    Location:743 → 797
    SH3_Intersectin1_1; First Src homology 3 domain (or SH3A) of Intersectin-1
    cd11989
    Location:911 → 962
    SH3_Intersectin1_2; Second Src homology 3 domain (or SH3B) of Intersectin-1
    cd11995
    Location:1081 → 1134
    SH3_Intersectin1_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-1
    COG1196
    Location:359 → 687
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00160
    Location:1161 → 1344
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    pfam16617
    Location:797 → 911
    INTAP; Intersectin and clathrin adaptor AP2 binding region
    pfam16652
    Location:1363 → 1505
    PH_13; Pleckstrin homology domain
    NF033761
    Location:95 → 179
    gliding_GltJ; adventurous gliding motility protein GltJ
    cl17036
    Location:1000 → 1061
    SH3; Src Homology 3 domain superfamily

  3. XM_028845346.1 → XP_028701179.1  intersectin-1 isoform X3

    Conserved Domains (11) summary
    cd08375
    Location:1510 → 1644
    C2_Intersectin; C2 domain present in Intersectin
    smart00027
    Location:213 → 308
    EH; Eps15 homology domain
    cd11987
    Location:743 → 802
    SH3_Intersectin1_1; First Src homology 3 domain (or SH3A) of Intersectin-1
    cd11989
    Location:916 → 967
    SH3_Intersectin1_2; Second Src homology 3 domain (or SH3B) of Intersectin-1
    cd11995
    Location:1086 → 1139
    SH3_Intersectin1_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-1
    COG1196
    Location:359 → 687
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00160
    Location:1166 → 1349
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    pfam16617
    Location:802 → 916
    INTAP; Intersectin and clathrin adaptor AP2 binding region
    pfam16652
    Location:1368 → 1510
    PH_13; Pleckstrin homology domain
    NF033761
    Location:95 → 179
    gliding_GltJ; adventurous gliding motility protein GltJ
    cl17036
    Location:1005 → 1066
    SH3; Src Homology 3 domain superfamily

  4. XM_028845343.1 → XP_028701176.1  intersectin-1 isoform X1

    UniProtKB/TrEMBL
    A0A1D5Q3A8
    Related
    ENSMMUP00000042520.2, ENSMMUT00000076177.2
    Conserved Domains (12) summary
    cd08375
    Location:1581 → 1715
    C2_Intersectin; C2 domain present in Intersectin
    smart00027
    Location:213 → 308
    EH; Eps15 homology domain
    cd11989
    Location:916 → 967
    SH3_Intersectin1_2; Second Src homology 3 domain (or SH3B) of Intersectin-1
    cd11991
    Location:1005 → 1056
    SH3_Intersectin1_3; Third Src homology 3 domain (or SH3C) of Intersectin-1
    cd11993
    Location:1073 → 1137
    SH3_Intersectin1_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-1
    cd11995
    Location:1157 → 1210
    SH3_Intersectin1_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-1
    COG1196
    Location:359 → 687
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00160
    Location:1237 → 1420
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    pfam16617
    Location:802 → 916
    INTAP; Intersectin and clathrin adaptor AP2 binding region
    pfam16652
    Location:1439 → 1581
    PH_13; Pleckstrin homology domain
    NF033761
    Location:95 → 179
    gliding_GltJ; adventurous gliding motility protein GltJ
    cl17036
    Location:743 → 802
    SH3; Src Homology 3 domain superfamily

  5. XM_028845348.1 → XP_028701181.1  intersectin-1 isoform X5

    UniProtKB/TrEMBL
    F7AQM9
    Conserved Domains (9) summary
    smart00027
    Location:213 → 308
    EH; Eps15 homology domain
    cd11991
    Location:1005 → 1056
    SH3_Intersectin1_3; Third Src homology 3 domain (or SH3C) of Intersectin-1
    cd11993
    Location:1073 → 1137
    SH3_Intersectin1_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-1
    cd11995
    Location:1157 → 1210
    SH3_Intersectin1_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-1
    PHA03247
    Location:95 → 221
    PHA03247; large tegument protein UL36; Provisional
    COG1196
    Location:359 → 687
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00160
    Location:1237 → 1390
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    pfam16617
    Location:802 → 916
    INTAP; Intersectin and clathrin adaptor AP2 binding region
    cl17036
    Location:743 → 802
    SH3; Src Homology 3 domain superfamily

  6. XM_028845352.1 → XP_028701185.1  intersectin-1 isoform X9

    UniProtKB/TrEMBL
    F7AQM3, F7AQM9
    Related
    ENSMMUP00000010022.4, ENSMMUT00000010682.4
    Conserved Domains (7) summary
    smart00027
    Location:213 → 308
    EH; Eps15 homology domain
    cd11987
    Location:743 → 797
    SH3_Intersectin1_1; First Src homology 3 domain (or SH3A) of Intersectin-1
    cd11995
    Location:1081 → 1134
    SH3_Intersectin1_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-1
    PHA03247
    Location:95 → 221
    PHA03247; large tegument protein UL36; Provisional
    COG1196
    Location:359 → 687
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam16617
    Location:797 → 911
    INTAP; Intersectin and clathrin adaptor AP2 binding region
    cl17036
    Location:1000 → 1061
    SH3; Src Homology 3 domain superfamily

  7. XM_028845350.1 → XP_028701183.1  intersectin-1 isoform X7

    UniProtKB/TrEMBL
    F7AQM9
    Conserved Domains (8) summary
    smart00027
    Location:213 → 308
    EH; Eps15 homology domain
    cd11987
    Location:743 → 797
    SH3_Intersectin1_1; First Src homology 3 domain (or SH3A) of Intersectin-1
    cd11991
    Location:1000 → 1051
    SH3_Intersectin1_3; Third Src homology 3 domain (or SH3C) of Intersectin-1
    cd11995
    Location:1152 → 1205
    SH3_Intersectin1_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-1
    PHA03247
    Location:95 → 221
    PHA03247; large tegument protein UL36; Provisional
    COG1196
    Location:359 → 687
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam16617
    Location:797 → 911
    INTAP; Intersectin and clathrin adaptor AP2 binding region
    cl17036
    Location:1068 → 1132
    SH3; Src Homology 3 domain superfamily

  8. XM_028845351.1 → XP_028701184.1  intersectin-1 isoform X8

    UniProtKB/TrEMBL
    F7AQM9
    Conserved Domains (6) summary
    smart00027
    Location:213 → 308
    EH; Eps15 homology domain
    cd11995
    Location:1086 → 1139
    SH3_Intersectin1_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-1
    PHA03247
    Location:95 → 221
    PHA03247; large tegument protein UL36; Provisional
    COG1196
    Location:359 → 687
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam16617
    Location:802 → 916
    INTAP; Intersectin and clathrin adaptor AP2 binding region
    cl17036
    Location:1005 → 1066
    SH3; Src Homology 3 domain superfamily

  9. XM_028845349.1 → XP_028701182.1  intersectin-1 isoform X6

    UniProtKB/TrEMBL
    F7AQM9
    Conserved Domains (7) summary
    smart00027
    Location:213 → 308
    EH; Eps15 homology domain
    cd11991
    Location:1005 → 1056
    SH3_Intersectin1_3; Third Src homology 3 domain (or SH3C) of Intersectin-1
    cd11995
    Location:1157 → 1210
    SH3_Intersectin1_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-1
    PHA03247
    Location:95 → 221
    PHA03247; large tegument protein UL36; Provisional
    COG1196
    Location:359 → 687
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam16617
    Location:802 → 916
    INTAP; Intersectin and clathrin adaptor AP2 binding region
    cl17036
    Location:1073 → 1137
    SH3; Src Homology 3 domain superfamily
Nucleotide Protein
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