TLR10 toll like receptor 10 [Macaca mulatta (Rhesus monkey)] - Gene

Summary

Official Symbol: TLR10provided by VGNC
Official Full Name: toll like receptor 10provided by VGNC
Primary source: VGNC:VGNC:78392
Locus tag: EGK_15647
See related: Ensembl:ENSMMUG00000003373
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Macaca mulatta
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs: human all
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Genomic context

Location:: chromosome: 5

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
103	current	Mmul_10 (GCF_003339765.1)	5	NC_041758.1 (37910552..37921489, complement)
102	previous assembly	Mmul_8.0.1 (GCF_000772875.2)	5	NC_027897.1 (38420183..38431132, complement)

Chromosome 5 - NC_041758.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables Toll-like receptor 2 binding	IEA Inferred from Electronic Annotation more info	PubMed
enables lipopeptide binding	IEA Inferred from Electronic Annotation more info	PubMed
enables transmembrane signaling receptor activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to bacterial lipopeptide	IEA Inferred from Electronic Annotation more info	PubMed
involved_in immune response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in toll-like receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: toll-like receptor 10

NP_001123906.1

EC 3.2.2.6

XP_014993639.2

EC 3.2.2.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001130434.1 → NP_001123906.1 toll-like receptor 10 precursor

See identical proteins and their annotated locations for NP_001123906.1

Status: PROVISIONAL

Source sequence(s)

AB445686

UniProtKB/TrEMBL

A0A8J8Y4H9, B3Y674, G7MSR0

Related

ENSMMUP00000035347.2, ENSMMUT00000042348.3

Conserved Domains (7) summary

smart00082
Location:522 → 574

LRRCT; Leucine rich repeat C-terminal domain

smart00255
Location:633 → 775

TIR; Toll - interleukin 1 - resistance

COG4886
Location:289 → 522

LRR; Leucine-rich repeat (LRR) protein [Transcription]

sd00031
Location:50 → 73

LRR_1; leucine-rich repeat [structural motif]

sd00033
Location:491 → 513

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:72 → 129

LRR_8; Leucine rich repeat

cl39015
Location:39 → 163

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

NC_041758.1 Reference Mmul_10 Primary Assembly

Range

37910552..37921489 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_015138153.2 → XP_014993639.2 toll-like receptor 10 isoform X1

UniProtKB/TrEMBL

F7EUU3

Conserved Domains (7) summary

smart00082
Location:522 → 574

LRRCT; Leucine rich repeat C-terminal domain

smart00255
Location:633 → 775

TIR; Toll - interleukin 1 - resistance

COG4886
Location:289 → 522

LRR; Leucine-rich repeat (LRR) protein [Transcription]

sd00031
Location:50 → 73

LRR_1; leucine-rich repeat [structural motif]

sd00033
Location:491 → 513

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:73 → 129

LRR_8; Leucine rich repeat

cl29113
Location:39 → 163

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...