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NTRK3 neurotrophic receptor tyrosine kinase 3 [ Macaca mulatta (Rhesus monkey) ]

Gene ID: 697615, updated on 17-Aug-2024

Summary

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Official Symbol
NTRK3provided by VGNC
Official Full Name
neurotrophic receptor tyrosine kinase 3provided by VGNC
Primary source
VGNC:VGNC:75542
See related
Ensembl:ENSMMUG00000001386
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Macaca mulatta
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs
human mouse all
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Genomic context

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See NTRK3 in Genome Data Viewer
Location:
chromosome: 7
Exon count:
22
Annotation release Status Assembly Chr Location
103 current Mmul_10 (GCF_003339765.1) 7 NC_041760.1 (66645145..67034967, complement)
102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 7 NC_027899.1 (65886665..66272979, complement)

Chromosome 7 - NC_041760.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC106999276 Neighboring gene uncharacterized LOC114679266 Neighboring gene mitochondrial ribosomal protein L46 Neighboring gene mitochondrial ribosomal protein S11

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Dorsal Amygdala Neurotrophin-3 Decreases Anxious Temperament in Primates. Fox AS, et al. Biol Psychiatry, 2019 Dec 15. PMID 31422797, Free PMC Article
  2. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
  3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Dorsal Amygdala Neurotrophin-3 Decreases Anxious Temperament in Primates.
    Title: Dorsal Amygdala Neurotrophin-3 Decreases Anxious Temperament in Primates.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables neurotrophin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables neurotrophin receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables transmembrane receptor protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cellular response to nerve growth factor stimulus IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in axon IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of receptor complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
NT-3 growth factor receptor
NP_001252566.1
XP_014998420.1
XP_014998421.1
XP_014998422.1
XP_028706055.1
XP_028706056.1
XP_028706057.1
XP_028706058.1
XP_028706059.1
XP_028706060.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001265637.1 → NP_001252566.1  NT-3 growth factor receptor precursor

    See identical proteins and their annotated locations for NP_001252566.1

    Status: PROVISIONAL

    Source sequence(s)
    JV667233
    UniProtKB/TrEMBL
    F7D0R9, G7MYR2, I2CY61
    Related
    ENSMMUP00000001849.4, ENSMMUT00000001962.4
    Conserved Domains (7) summary
    cd05094
    Location:532 → 818
    PTKc_TrkC; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase C
    sd00031
    Location:105 → 128
    LRR_1; leucine-rich repeat [structural motif]
    pfam00047
    Location:214 → 299
    ig; Immunoglobulin domain
    pfam13855
    Location:103 → 160
    LRR_8; Leucine rich repeat
    pfam16920
    Location:163 → 208
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    cd00096
    Location:218 → 221
    Ig; Ig strand A' [structural motif]
    cd04971
    Location:304 → 396
    IgI_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB, and TrkC; member of the I-set of Ig superfamily (IgSF) domains

RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

  1. NC_041760.1 Reference Mmul_10 Primary Assembly

    Range
    66645145..67034967 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015142935.2 → XP_014998421.1  NT-3 growth factor receptor isoform X4

    UniProtKB/TrEMBL
    G7MYR2
    Conserved Domains (7) summary
    cd05094
    Location:524 → 810
    PTKc_TrkC; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase C
    sd00031
    Location:105 → 128
    LRR_1; leucine-rich repeat [structural motif]
    pfam00047
    Location:214 → 299
    ig; Immunoglobulin domain
    pfam13855
    Location:103 → 160
    LRR_8; Leucine rich repeat
    pfam16920
    Location:163 → 208
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    cd00096
    Location:218 → 221
    Ig; Ig strand A' [structural motif]
    cd04971
    Location:304 → 396
    IgI_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB, and TrkC; member of the I-set of Ig superfamily (IgSF) domains

  2. XM_028850223.1 → XP_028706056.1  NT-3 growth factor receptor isoform X2

    UniProtKB/TrEMBL
    A0A1D5QNZ5, G7MYR2
    Related
    ENSMMUP00000049772.2, ENSMMUT00000061771.2
    Conserved Domains (7) summary
    cd05094
    Location:524 → 835
    PTKc_TrkC; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase C
    sd00031
    Location:105 → 128
    LRR_1; leucine-rich repeat [structural motif]
    pfam00047
    Location:214 → 299
    ig; Immunoglobulin domain
    pfam13855
    Location:103 → 160
    LRR_8; Leucine rich repeat
    pfam16920
    Location:163 → 208
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    cd00096
    Location:218 → 221
    Ig; Ig strand A' [structural motif]
    cd04971
    Location:304 → 396
    IgI_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB, and TrkC; member of the I-set of Ig superfamily (IgSF) domains

  3. XM_015142934.2 → XP_014998420.1  NT-3 growth factor receptor isoform X3

    UniProtKB/TrEMBL
    G7MYR2
    Conserved Domains (7) summary
    cd05094
    Location:532 → 832
    PTKc_TrkC; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase C
    sd00031
    Location:105 → 128
    LRR_1; leucine-rich repeat [structural motif]
    pfam00047
    Location:214 → 299
    ig; Immunoglobulin domain
    pfam13855
    Location:103 → 160
    LRR_8; Leucine rich repeat
    pfam16920
    Location:163 → 208
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    cd00096
    Location:218 → 221
    Ig; Ig strand A' [structural motif]
    cd04971
    Location:304 → 396
    IgI_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB, and TrkC; member of the I-set of Ig superfamily (IgSF) domains

  4. XM_028850222.1 → XP_028706055.1  NT-3 growth factor receptor isoform X1

    UniProtKB/TrEMBL
    A0A1D5QHC7, G7MYR2
    Related
    ENSMMUP00000047448.1, ENSMMUT00000072071.2
    Conserved Domains (7) summary
    cd05094
    Location:532 → 843
    PTKc_TrkC; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase C
    sd00031
    Location:105 → 128
    LRR_1; leucine-rich repeat [structural motif]
    pfam00047
    Location:214 → 299
    ig; Immunoglobulin domain
    pfam13855
    Location:103 → 160
    LRR_8; Leucine rich repeat
    pfam16920
    Location:163 → 208
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    cd00096
    Location:218 → 221
    Ig; Ig strand A' [structural motif]
    cd04971
    Location:304 → 396
    IgI_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB, and TrkC; member of the I-set of Ig superfamily (IgSF) domains

  5. XM_028850227.1 → XP_028706060.1  NT-3 growth factor receptor isoform X9

    UniProtKB/TrEMBL
    G7MYR2
    Conserved Domains (6) summary
    cd04971
    Location:319 → 396
    Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
    cd04972
    Location:211 → 301
    Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
    cd05094
    Location:532 → 857
    PTKc_TrkC; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase C
    sd00031
    Location:105 → 128
    LRR_1; leucine-rich repeat [structural motif]
    pfam16920
    Location:163 → 208
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    pfam13855
    Location:104 → 160
    LRR_8; Leucine rich repeat

  6. XM_028850224.1 → XP_028706057.1  NT-3 growth factor receptor isoform X5

    UniProtKB/TrEMBL
    H9F0W5
    Conserved Domains (7) summary
    cd04971
    Location:319 → 396
    Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
    cd04972
    Location:211 → 301
    Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
    smart00013
    Location:31 → 56
    LRRNT; Leucine rich repeat N-terminal domain
    sd00031
    Location:105 → 128
    LRR_1; leucine-rich repeat [structural motif]
    pfam16920
    Location:163 → 208
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    pfam13855
    Location:104 → 160
    LRR_8; Leucine rich repeat
    cl21453
    Location:532 → 713
    PKc_like; Protein Kinases, catalytic domain

  7. XM_028850225.1 → XP_028706058.1  NT-3 growth factor receptor isoform X6

    UniProtKB/TrEMBL
    H9F0W5
    Conserved Domains (7) summary
    cd04971
    Location:319 → 396
    Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
    cd04972
    Location:211 → 301
    Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
    smart00013
    Location:31 → 56
    LRRNT; Leucine rich repeat N-terminal domain
    sd00031
    Location:105 → 128
    LRR_1; leucine-rich repeat [structural motif]
    pfam16920
    Location:163 → 208
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    pfam13855
    Location:104 → 160
    LRR_8; Leucine rich repeat
    cl21453
    Location:532 → 630
    PKc_like; Protein Kinases, catalytic domain

  8. XM_028850226.1 → XP_028706059.1  NT-3 growth factor receptor isoform X8

    UniProtKB/TrEMBL
    F7D0E6
    Conserved Domains (7) summary
    sd00031
    Location:105 → 128
    LRR_1; leucine-rich repeat [structural motif]
    pfam00047
    Location:214 → 299
    ig; Immunoglobulin domain
    pfam01462
    Location:31 → 51
    LRRNT; Leucine rich repeat N-terminal domain
    pfam13855
    Location:103 → 160
    LRR_8; Leucine rich repeat
    pfam16920
    Location:163 → 208
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    cd00096
    Location:218 → 221
    Ig; Ig strand A' [structural motif]
    cd04971
    Location:304 → 396
    IgI_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB, and TrkC; member of the I-set of Ig superfamily (IgSF) domains

  9. XM_015142936.2 → XP_014998422.1  NT-3 growth factor receptor isoform X7

    UniProtKB/TrEMBL
    F7D0C9, F7D0E6, H9FUZ7
    Related
    ENSMMUP00000001852.3, ENSMMUT00000001965.3
    Conserved Domains (7) summary
    sd00031
    Location:105 → 128
    LRR_1; leucine-rich repeat [structural motif]
    pfam00047
    Location:214 → 299
    ig; Immunoglobulin domain
    pfam01462
    Location:31 → 51
    LRRNT; Leucine rich repeat N-terminal domain
    pfam13855
    Location:103 → 160
    LRR_8; Leucine rich repeat
    pfam16920
    Location:163 → 208
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    cd00096
    Location:218 → 221
    Ig; Ig strand A' [structural motif]
    cd04971
    Location:304 → 396
    IgI_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB, and TrkC; member of the I-set of Ig superfamily (IgSF) domains
Nucleotide Protein
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