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CHN2 chimerin 2 [ Macaca mulatta (Rhesus monkey) ]

Gene ID: 697231, updated on 17-Aug-2024

Summary

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Official Symbol
CHN2provided by VGNC
Official Full Name
chimerin 2provided by VGNC
Primary source
VGNC:VGNC:80861
See related
Ensembl:ENSMMUG00000008329
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Macaca mulatta
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs
human mouse all
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Genomic context

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See CHN2 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
19
Annotation release Status Assembly Chr Location
103 current Mmul_10 (GCF_003339765.1) 3 NC_041756.1 (85583172..85906146, complement)
102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 3 NC_027895.1 (78580297..78958827, complement)

Chromosome 3 - NC_041756.1Genomic Context describing neighboring genes Neighboring gene general transcription factor 3C polypeptide 6 pseudogene Neighboring gene uncharacterized LOC106997478 Neighboring gene proline rich 15 Neighboring gene uncharacterized LOC114676951 Neighboring gene carboxypeptidase vitellogenic like Neighboring gene uncharacterized LOC106997479

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of small GTPase mediated signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
beta-chimaerin
Names
chimerin (chimaerin) 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001261577.1 → NP_001248506.1  beta-chimaerin

    See identical proteins and their annotated locations for NP_001248506.1

    Status: PROVISIONAL

    Source sequence(s)
    JU322076
    UniProtKB/TrEMBL
    A0A1D5R9C0, A0A1D5RC06, H9ETX3
    Related
    ENSMMUP00000057848.2, ENSMMUT00000073602.2
    Conserved Domains (3) summary
    cd10352
    Location:52 → 138
    SH2_a2chimerin_b2chimerin; Src homology 2 (SH2) domain found in alpha2-chimerin and beta2-chimerin proteins
    cd04372
    Location:275 → 468
    RhoGAP_chimaerin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms ...
    cd20857
    Location:210 → 270
    C1_betaCHN; protein kinase C conserved region 1 (C1 domain) found in beta-chimaerin and similar proteins

RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

  1. NC_041756.1 Reference Mmul_10 Primary Assembly

    Range
    85583172..85906146 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015133784.2 → XP_014989270.1  beta-chimaerin isoform X1

    UniProtKB/TrEMBL
    A0A1D5R9C0, F6VWF7
    Related
    ENSMMUP00000035186.3, ENSMMUT00000042187.3
    Conserved Domains (3) summary
    cd10352
    Location:65 → 151
    SH2_a2chimerin_b2chimerin; Src homology 2 (SH2) domain found in alpha2-chimerin and beta2-chimerin proteins
    cd04372
    Location:288 → 481
    RhoGAP_chimaerin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms ...
    cd20857
    Location:223 → 283
    C1_betaCHN; protein kinase C conserved region 1 (C1 domain) found in beta-chimaerin and similar proteins

  2. XM_028844820.1 → XP_028700653.1  beta-chimaerin isoform X2

    UniProtKB/TrEMBL
    A0A1D5R9C0
    Related
    ENSMMUP00000056911.2, ENSMMUT00000058935.2
    Conserved Domains (3) summary
    cd10352
    Location:37 → 123
    SH2_a2chimerin_b2chimerin; Src homology 2 (SH2) domain found in alpha2-chimerin and beta2-chimerin proteins
    cd04372
    Location:260 → 453
    RhoGAP_chimaerin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms ...
    cd20857
    Location:195 → 255
    C1_betaCHN; protein kinase C conserved region 1 (C1 domain) found in beta-chimaerin and similar proteins

  3. XM_015133785.2 → XP_014989271.1  beta-chimaerin isoform X4

    UniProtKB/TrEMBL
    A0A1D5QMR4, A0A1D5R9C0
    Related
    ENSMMUP00000049339.1, ENSMMUT00000066748.2
    Conserved Domains (3) summary
    cd10352
    Location:53 → 139
    SH2_a2chimerin_b2chimerin; Src homology 2 (SH2) domain found in alpha2-chimerin and beta2-chimerin proteins
    cd04372
    Location:276 → 469
    RhoGAP_chimaerin; RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two ...
    pfam00130
    Location:216 → 268
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

  4. XM_028844821.1 → XP_028700654.1  beta-chimaerin isoform X5

    UniProtKB/TrEMBL
    H9EMY7
    Conserved Domains (2) summary
    cd04372
    Location:129 → 322
    RhoGAP_chimaerin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms ...
    pfam00130
    Location:69 → 119
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

  5. XM_015133786.2 → XP_014989272.1  beta-chimaerin isoform X3

    UniProtKB/TrEMBL
    H9EMY7
    Conserved Domains (2) summary
    cd04372
    Location:145 → 338
    RhoGAP_chimaerin; RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two ...
    pfam00130
    Location:85 → 137
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

  6. XM_015133787.2 → XP_014989273.1  beta-chimaerin isoform X6

    UniProtKB/TrEMBL
    H9EMY7
    Conserved Domains (2) summary
    cd04372
    Location:99 → 292
    RhoGAP_chimaerin; RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two ...
    pfam00130
    Location:39 → 91
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
Nucleotide Protein
Heading Accession and Version

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