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DLG3 discs large MAGUK scaffold protein 3 [ Macaca mulatta (Rhesus monkey) ]

Gene ID: 697179, updated on 17-Aug-2024

Summary

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Official Symbol
DLG3provided by VGNC
Official Full Name
discs large MAGUK scaffold protein 3provided by VGNC
Primary source
VGNC:VGNC:71919
Locus tag
EGK_20615
See related
Ensembl:ENSMMUG00000013948
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Macaca mulatta
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs
human mouse all
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Genomic context

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See DLG3 in Genome Data Viewer
Location:
chromosome: X
Exon count:
25
Annotation release Status Assembly Chr Location
103 current Mmul_10 (GCF_003339765.1) X NC_041774.1 (67490256..67548415)
102 previous assembly Mmul_8.0.1 (GCF_000772875.2) X NC_027913.1 (65122293..65289481)

Chromosome X - NC_041774.1Genomic Context describing neighboring genes Neighboring gene kinesin family member 4A Neighboring gene trafficking protein particle complex subunit 2-like protein Neighboring gene uncharacterized LOC106995235 Neighboring gene U4 spliceosomal RNA Neighboring gene glycerophosphodiester phosphodiesterase domain containing 2 Neighboring gene testis expressed 11 Neighboring gene small integral membrane protein 30 Neighboring gene WASH complex subunit 3 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables kinase binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in chemical synaptic transmission IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in neuromuscular junction IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in neuron projection IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in postsynaptic density membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
disks large homolog 3
Names
membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001194912.2 → NP_001181841.1  disks large homolog 3

    See identical proteins and their annotated locations for NP_001181841.1

    Status: PROVISIONAL

    Source sequence(s)
    QNVO02003166
    UniProtKB/TrEMBL
    F7D6C3, H9FA99
    Related
    ENSMMUP00000041000.2, ENSMMUT00000047963.3
    Conserved Domains (6) summary
    cd12029
    Location:483 → 549
    SH3_DLG3; Src Homology 3 domain of Disks Large homolog 3
    smart00228
    Location:224 → 294
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:365 → 443
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:607 → 785
    Guanylate_kin; Guanylate kinase
    pfam10600
    Location:292 → 366
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    pfam10608
    Location:52 → 130
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

  1. NC_041774.1 Reference Mmul_10 Primary Assembly

    Range
    67490256..67548415
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015127624.2 → XP_014983110.1  disks large homolog 3 isoform X2

    UniProtKB/TrEMBL
    A0A5F7ZD27, H9FA99
    Related
    ENSMMUP00000063514.1, ENSMMUT00000100638.1
    Conserved Domains (5) summary
    cd12029
    Location:520 → 586
    SH3_DLG3; Src Homology 3 domain of Disks Large homolog 3
    cd00992
    Location:402 → 480
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:662 → 840
    Guanylate_kin; Guanylate kinase
    pfam10600
    Location:329 → 403
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    pfam10608
    Location:52 → 148
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

  2. XM_015127623.2 → XP_014983109.1  disks large homolog 3 isoform X1

    UniProtKB/TrEMBL
    F6UBK1, H9FA99
    Related
    ENSMMUP00000040999.2, ENSMMUT00000047962.3
    Conserved Domains (5) summary
    cd12029
    Location:520 → 586
    SH3_DLG3; Src Homology 3 domain of Disks Large homolog 3
    cd00992
    Location:402 → 480
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:676 → 854
    Guanylate_kin; Guanylate kinase
    pfam10600
    Location:329 → 403
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    pfam10608
    Location:52 → 148
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

  3. XM_015127626.2 → XP_014983112.1  disks large homolog 3 isoform X4

    UniProtKB/TrEMBL
    A0A8J8YFK3, F6SE42, G7NRU6, H9FA99
    Related
    ENSMMUP00000018335.2, ENSMMUT00000019579.4
    Conserved Domains (5) summary
    cd12029
    Location:520 → 586
    SH3_DLG3; Src Homology 3 domain of Disks Large homolog 3
    cd00992
    Location:402 → 480
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:658 → 836
    Guanylate_kin; Guanylate kinase
    pfam10600
    Location:329 → 403
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    pfam10608
    Location:52 → 148
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

  4. XM_015127627.2 → XP_014983113.1  disks large homolog 3 isoform X5

    UniProtKB/TrEMBL
    H9FA99
    Conserved Domains (5) summary
    cd12029
    Location:520 → 586
    SH3_DLG3; Src Homology 3 domain of Disks Large homolog 3
    cd00992
    Location:402 → 480
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:644 → 822
    Guanylate_kin; Guanylate kinase
    pfam10600
    Location:329 → 403
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    pfam10608
    Location:52 → 148
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

  5. XM_015127625.2 → XP_014983111.1  disks large homolog 3 isoform X3

    UniProtKB/TrEMBL
    H9FA99
    Conserved Domains (5) summary
    cd12029
    Location:502 → 568
    SH3_DLG3; Src Homology 3 domain of Disks Large homolog 3
    cd00992
    Location:384 → 462
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:658 → 836
    Guanylate_kin; Guanylate kinase
    pfam10600
    Location:311 → 385
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    pfam10608
    Location:52 → 130
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

  6. XM_001085782.4 → XP_001085782.2  disks large homolog 3 isoform X6

    See identical proteins and their annotated locations for XP_001085782.2

    UniProtKB/TrEMBL
    H9FA99
    Conserved Domains (5) summary
    cd12029
    Location:502 → 568
    SH3_DLG3; Src Homology 3 domain of Disks Large homolog 3
    cd00992
    Location:384 → 462
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:626 → 804
    Guanylate_kin; Guanylate kinase
    pfam10600
    Location:311 → 385
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    pfam10608
    Location:52 → 130
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

  7. XM_015127628.2 → XP_014983114.1  disks large homolog 3 isoform X7

    UniProtKB/TrEMBL
    A0A5F8A2Q6, I2CWJ9
    Related
    ENSMMUP00000071640.1, ENSMMUT00000093036.1
    Conserved Domains (3) summary
    cd00992
    Location:48 → 126
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:322 → 500
    Guanylate_kin; Guanylate kinase
    cl17036
    Location:166 → 232
    SH3; Src Homology 3 domain superfamily

  8. XM_028841685.1 → XP_028697518.1  disks large homolog 3 isoform X8

    UniProtKB/TrEMBL
    A0A5F8A2Q6
    Conserved Domains (3) summary
    cd12029
    Location:166 → 232
    SH3_DLG3; Src Homology 3 domain of Disks Large homolog 3
    cd00992
    Location:48 → 126
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:290 → 468
    Guanylate_kin; Guanylate kinase

  9. XM_015127629.2 → XP_014983115.1  disks large homolog 3 isoform X9

    Conserved Domains (2) summary
    pfam00625
    Location:175 → 353
    Guanylate_kin; Guanylate kinase
    cl17036
    Location:19 → 85
    SH3; Src Homology 3 domain superfamily

  10. XM_028841687.1 → XP_028697520.1  disks large homolog 3 isoform X9

    Conserved Domains (2) summary
    pfam00625
    Location:175 → 353
    Guanylate_kin; Guanylate kinase
    cl17036
    Location:19 → 85
    SH3; Src Homology 3 domain superfamily

  11. XM_028841686.1 → XP_028697519.1  disks large homolog 3 isoform X9

    Conserved Domains (2) summary
    pfam00625
    Location:175 → 353
    Guanylate_kin; Guanylate kinase
    cl17036
    Location:19 → 85
    SH3; Src Homology 3 domain superfamily
Nucleotide Protein
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