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Aarsd1 alanyl-tRNA synthetase domain containing 1 [ Mus musculus (house mouse) ]

Gene ID: 69684, updated on 4-Jan-2025

Summary

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Official Symbol
Aarsd1provided by MGI
Official Full Name
alanyl-tRNA synthetase domain containing 1provided by MGI
Primary source
MGI:MGI:1916934
See related
Ensembl:ENSMUSG00000075528 AllianceGenome:MGI:1916934
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AlaX; AlaXp-II; 1110069E20Rik; 2310044P18Rik
Summary
Enables Ser-tRNA(Ala) hydrolase activity. Acts upstream of or within regulation of translational fidelity. Predicted to be located in cytoplasm. Is expressed in submandibular gland primordium. Orthologous to several human genes including AARSD1 (alanyl-tRNA synthetase domain containing 1). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 22.9), liver E14 (RPKM 15.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Aarsd1 in Genome Data Viewer
Location:
11 D; 11 64.95 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (101297489..101308422, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (101406663..101417508, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_30761 Neighboring gene predicted gene, 51949 Neighboring gene predicted gene, 25475 Neighboring gene prostaglandin E synthase 3 like Neighboring gene microRNA 6929 Neighboring gene STARR-positive B cell enhancer ABC_E596 Neighboring gene RUN domain containing 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. p23H implicated as cis/trans regulator of AlaXp-directed editing for mammalian cell homeostasis. Nawaz MH, et al. Proc Natl Acad Sci U S A, 2011 Feb 15. PMID 21285375, Free PMC Article
  2. A Remodeled Hsp90 Molecular Chaperone Ensemble with the Novel Cochaperone Aarsd1 Is Required for Muscle Differentiation. Echeverría PC, et al. Mol Cell Biol, 2016 Apr. PMID 26884463, Free PMC Article
  3. Distinct domains of tRNA synthetase recognize the same base pair. Beebe K, et al. Nature, 2008 Jan 3. PMID 18172502
  4. Brn3a and Nurr1 mediate a gene regulatory pathway for habenula development. Quina LA, et al. J Neurosci, 2009 Nov 11. PMID 19906978, Free PMC Article
  5. Bioinformatics and cellular signaling. Papin J, et al. Curr Opin Biotechnol, 2004 Feb. PMID 15102471

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Artificially maintaining Hsp90alpha or knocking down Aarsd1L expression interferes with the differentiation of C2C12 myotubes.
    Title: A Remodeled Hsp90 Molecular Chaperone Ensemble with the Novel Cochaperone Aarsd1 Is Required for Muscle Differentiation.
  2. Deacylates mischarged tRNA(Ala) (AlaXp activity)
    Title: Distinct domains of tRNA synthetase recognize the same base pair.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables Ser-tRNA(Ala) hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables Ser-tRNA(Ala) hydrolase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables alanine-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables aminoacyl-tRNA editing activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in alanyl-tRNA aminoacylation IEA
Inferred from Electronic Annotation
more info
  
involved_in aminoacyl-tRNA metabolism involved in translational fidelity IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of translational fidelity IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of translational fidelity IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
alanyl-tRNA editing protein Aarsd1
Names
alanyl-tRNA deacylase alaX
alanyl-tRNA synthetase domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_144829.1 → NP_659078.1  alanyl-tRNA editing protein Aarsd1

    See identical proteins and their annotated locations for NP_659078.1

    Status: PROVISIONAL

    Source sequence(s)
    BC005711
    Consensus CDS
    CCDS25467.1
    UniProtKB/Swiss-Prot
    Q3THG9, Q3UWH8, Q8BVJ6, Q99JS9
    Related
    ENSMUSP00000067912.9, ENSMUST00000070395.9
    Conserved Domains (2) summary
    COG2872
    Location:8 → 248
    AlaX; Ser-tRNA(Ala) deacylase AlaX (editing enzyme) [Translation, ribosomal structure and biogenesis]
    cl08469
    Location:43 → 231
    tRNA_SAD; Threonyl and Alanyl tRNA synthetase second additional domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    101297489..101308422 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006534121.4 → XP_006534184.1  alanyl-tRNA editing protein Aarsd1 isoform X2

    Conserved Domains (1) summary
    PRK13902
    Location:29 → 241
    alaS; alanyl-tRNA synthetase; Provisional

  2. XM_036156964.1 → XP_036012857.1  alanyl-tRNA editing protein Aarsd1 isoform X1

    Conserved Domains (2) summary
    COG0013
    Location:1 → 303
    AlaS; Alanyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]
    COG2872
    Location:1 → 143
    AlaX; Ser-tRNA(Ala) deacylase AlaX (editing enzyme) [Translation, ribosomal structure and biogenesis]

  3. XM_036156965.1 → XP_036012858.1  alanyl-tRNA editing protein Aarsd1 isoform X2

    Conserved Domains (1) summary
    PRK13902
    Location:29 → 241
    alaS; alanyl-tRNA synthetase; Provisional
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3THG9.2 GenPept UniProtKB/Swiss-Prot:Q3THG9

Gene LinkOut

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Chemical Information
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