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NPR2 natriuretic peptide receptor 2 [ Macaca mulatta (Rhesus monkey) ]

Gene ID: 695750, updated on 17-Aug-2024

Summary

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Official Symbol
NPR2provided by VGNC
Official Full Name
natriuretic peptide receptor 2provided by VGNC
Primary source
VGNC:VGNC:75389
See related
Ensembl:ENSMMUG00000016334
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Macaca mulatta
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs
human mouse all
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Genomic context

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See NPR2 in Genome Data Viewer
Location:
chromosome: 15
Exon count:
22
Annotation release Status Assembly Chr Location
103 current Mmul_10 (GCF_003339765.1) 15 NC_041768.1 (48396916..48415320, complement)
102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 15 NC_027907.1 (48450454..48468917, complement)

Chromosome 15 - NC_041768.1Genomic Context describing neighboring genes Neighboring gene histidine triad nucleotide binding protein 2 Neighboring gene sperm associated antigen 8 Neighboring gene RGP1 homolog, RAB6A GEF complex partner 1 Neighboring gene microseminoprotein, prostate associated Neighboring gene glucosylceramidase beta 2 Neighboring gene uncharacterized LOC106993704

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables guanylate cyclase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables natriuretic peptide receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables peptide hormone binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cGMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in receptor guanylyl cyclase signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
atrial natriuretic peptide receptor 2
Names
natriuretic peptide receptor B
natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)
NP_001192269.1
XP_014972821.2
XP_014972822.2
XP_014972823.2
XP_028690061.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001205340.1 → NP_001192269.1  atrial natriuretic peptide receptor 2 precursor

    See identical proteins and their annotated locations for NP_001192269.1

    Status: VALIDATED

    Source sequence(s)
    JF275852
    UniProtKB/TrEMBL
    A0A5S6R6Z2, A0A8J8XC77, F2YI45, F7GRM1, G7NFC7
    Related
    ENSMMUP00000021453.3, ENSMMUT00000022938.4
    Conserved Domains (6) summary
    smart00044
    Location:825 → 1009
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    cd14042
    Location:518 → 792
    PK_GC-A_B; Pseudokinase domain of the membrane Guanylate Cyclase receptors, GC-A and GC-B
    pfam00211
    Location:852 → 1038
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam01094
    Location:44 → 397
    ANF_receptor; Receptor family ligand binding region
    pfam07701
    Location:801 → 846
    HNOBA; Heme NO binding associated
    cl10011
    Location:26 → 421
    Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily

RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

  1. NC_041768.1 Reference Mmul_10 Primary Assembly

    Range
    48396916..48415320 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015117335.2 → XP_014972821.2  atrial natriuretic peptide receptor 2 isoform X1

    UniProtKB/TrEMBL
    A0A5S6R6Z2, A0A8J8XC77, F7GRM1, G7NFC7
    Conserved Domains (4) summary
    smart00044
    Location:828 → 1012
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    cd14042
    Location:521 → 795
    PK_GC-A_B; Pseudokinase domain of the membrane Guanylate Cyclase receptors, GC-A and GC-B
    pfam07701
    Location:804 → 849
    HNOBA; Heme NO binding associated
    cl10011
    Location:26 → 421
    Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily

  2. XM_015117336.2 → XP_014972822.2  atrial natriuretic peptide receptor 2 isoform X2

    UniProtKB/TrEMBL
    A0A5F7ZBQ1
    Conserved Domains (4) summary
    cd06384
    Location:26 → 421
    PBP1_NPR_B; Ligand-binding domain of type B natriuretic peptide receptor
    smart00044
    Location:803 → 987
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    cd14042
    Location:489 → 770
    PK_GC-A_B; Pseudokinase domain of the membrane Guanylate Cyclase receptors, GC-A and GC-B
    pfam07701
    Location:779 → 824
    HNOBA; Heme NO binding associated

  3. XM_015117337.2 → XP_014972823.2  atrial natriuretic peptide receptor 2 isoform X3

    UniProtKB/TrEMBL
    A0A5F7ZBQ1, A0A5F7ZBY2
    Related
    ENSMMUP00000062110.1, ENSMMUT00000094097.1
    Conserved Domains (4) summary
    cd06384
    Location:26 → 421
    PBP1_NPR_B; Ligand-binding domain of type B natriuretic peptide receptor
    smart00044
    Location:800 → 984
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    cd14042
    Location:486 → 767
    PK_GC-A_B; Pseudokinase domain of the membrane Guanylate Cyclase receptors, GC-A and GC-B
    pfam07701
    Location:776 → 821
    HNOBA; Heme NO binding associated

  4. XM_028834228.1 → XP_028690061.1  atrial natriuretic peptide receptor 2 isoform X4

    UniProtKB/TrEMBL
    A0A5S6R6Z2, A0A8J8XC77, F7GRM1, G7NFC7
    Conserved Domains (4) summary
    smart00044
    Location:755 → 939
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    cd14042
    Location:448 → 722
    PK_GC-A_B; Pseudokinase domain of the membrane Guanylate Cyclase receptors, GC-A and GC-B
    pfam07701
    Location:731 → 776
    HNOBA; Heme NO binding associated
    cl10011
    Location:26 → 348
    Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily

RNA

  1. XR_001439992.2 RNA Sequence

Nucleotide Protein
Heading Accession and Version

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