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Hemk1 HemK methyltransferase family member 1 [ Mus musculus (house mouse) ]

Gene ID: 69536, updated on 27-Nov-2024

Summary

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Official Symbol
Hemk1provided by MGI
Official Full Name
HemK methyltransferase family member 1provided by MGI
Primary source
MGI:MGI:1916786
See related
Ensembl:ENSMUSG00000032579 AllianceGenome:MGI:1916786
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2310008M14Rik
Summary
Predicted to enable protein-(glutamine-N5) methyltransferase activity and protein-glutamine N-methyltransferase activity. Predicted to be involved in translational termination. Located in mitochondrion. Orthologous to human HEMK1 (HemK methyltransferase family member 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in kidney adult (RPKM 5.0), mammary gland adult (RPKM 4.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Hemk1 in Genome Data Viewer
Location:
9 F1; 9 58.0 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (107204281..107217640, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (107327082..107340437, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr9:107198795-107199096 Neighboring gene predicted gene 17040 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:107215338-107215525 Neighboring gene cytokine inducible SH2-containing protein Neighboring gene STARR-seq mESC enhancer starr_25171 Neighboring gene RIKEN cDNA 6430571L13 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:107240678-107240861 Neighboring gene STARR-positive B cell enhancer ABC_E6801 Neighboring gene RIKEN cDNA 4930429P21 gene Neighboring gene STARR-seq mESC enhancer starr_25172 Neighboring gene STARR-seq mESC enhancer starr_25173 Neighboring gene calcium channel, voltage-dependent, alpha 2/delta subunit 2 Neighboring gene predicted gene 17141

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  2. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
  3. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
  4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables protein methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein-(glutamine-N5) methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-(glutamine-N5) methyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein-glutamine N-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in translational termination IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 

General protein information

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Preferred Names
MTRF1L release factor glutamine methyltransferase
NP_598745.2
XP_006511887.1
XP_030100428.1
XP_036011139.1
XP_036011140.1
XP_036011141.1
XP_036011142.1
XP_036011143.1
XP_036011144.1
XP_036011145.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133984.2 → NP_598745.2  MTRF1L release factor glutamine methyltransferase

    See identical proteins and their annotated locations for NP_598745.2

    Status: VALIDATED

    Source sequence(s)
    AL672070
    Consensus CDS
    CCDS23488.1
    UniProtKB/Swiss-Prot
    B0QZU8, Q921L7
    Related
    ENSMUSP00000035196.8, ENSMUST00000035196.14
    Conserved Domains (1) summary
    TIGR03534
    Location:64 → 333
    RF_mod_PrmC; protein-(glutamine-N5) methyltransferase, release factor-specific

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    107204281..107217640 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036155246.1 → XP_036011139.1  MTRF1L release factor glutamine methyltransferase isoform X1

    UniProtKB/Swiss-Prot
    B0QZU8, Q921L7
    Conserved Domains (1) summary
    TIGR03534
    Location:64 → 333
    RF_mod_PrmC; protein-(glutamine-N5) methyltransferase, release factor-specific

  2. XM_030244568.2 → XP_030100428.1  MTRF1L release factor glutamine methyltransferase isoform X1

    UniProtKB/Swiss-Prot
    B0QZU8, Q921L7
    Conserved Domains (1) summary
    TIGR03534
    Location:64 → 333
    RF_mod_PrmC; protein-(glutamine-N5) methyltransferase, release factor-specific

  3. XM_036155251.1 → XP_036011144.1  MTRF1L release factor glutamine methyltransferase isoform X3

    Conserved Domains (1) summary
    TIGR03534
    Location:1 → 225
    RF_mod_PrmC; protein-(glutamine-N5) methyltransferase, release factor-specific

  4. XM_036155250.1 → XP_036011143.1  MTRF1L release factor glutamine methyltransferase isoform X3

    Conserved Domains (1) summary
    TIGR03534
    Location:1 → 225
    RF_mod_PrmC; protein-(glutamine-N5) methyltransferase, release factor-specific

  5. XM_036155248.1 → XP_036011141.1  MTRF1L release factor glutamine methyltransferase isoform X3

    Conserved Domains (1) summary
    TIGR03534
    Location:1 → 225
    RF_mod_PrmC; protein-(glutamine-N5) methyltransferase, release factor-specific

  6. XM_036155247.1 → XP_036011140.1  MTRF1L release factor glutamine methyltransferase isoform X2

    Conserved Domains (2) summary
    TIGR03534
    Location:107 → 235
    RF_mod_PrmC; protein-(glutamine-N5) methyltransferase, release factor-specific
    pfam17827
    Location:46 → 108
    PrmC_N; PrmC N-terminal domain

  7. XM_006511824.1 → XP_006511887.1  MTRF1L release factor glutamine methyltransferase isoform X3

    See identical proteins and their annotated locations for XP_006511887.1

    Conserved Domains (1) summary
    TIGR03534
    Location:1 → 225
    RF_mod_PrmC; protein-(glutamine-N5) methyltransferase, release factor-specific

  8. XM_036155249.1 → XP_036011142.1  MTRF1L release factor glutamine methyltransferase isoform X3

    Conserved Domains (1) summary
    TIGR03534
    Location:1 → 225
    RF_mod_PrmC; protein-(glutamine-N5) methyltransferase, release factor-specific

  9. XM_036155252.1 → XP_036011145.1  MTRF1L release factor glutamine methyltransferase isoform X4

    Conserved Domains (1) summary
    TIGR03534
    Location:64 → 186
    RF_mod_PrmC; protein-(glutamine-N5) methyltransferase, release factor-specific
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q921L7.2 GenPept UniProtKB/Swiss-Prot:Q921L7

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