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Zfp932 zinc finger protein 932 [ Mus musculus (house mouse) ]

Gene ID: 69504, updated on 4-Jan-2025

Summary

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Official Symbol
Zfp932provided by MGI
Official Full Name
zinc finger protein 932provided by MGI
Primary source
MGI:MGI:1916754
See related
Ensembl:ENSMUSG00000066613 AllianceGenome:MGI:1916754
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Znf431; 2310001H12Rik
Summary
Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; chromatin binding activity; and histone deacetylase binding activity. Involved in negative regulation of DNA-binding transcription factor activity and negative regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system; and skeleton. Orthologous to human ZNF17 (zinc finger protein 17). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Broad expression in CNS E18 (RPKM 7.3), frontal lobe adult (RPKM 6.3) and 22 other tissues See more
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Genomic context

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See Zfp932 in Genome Data Viewer
Location:
5 F; 5 53.29 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (110144334..110160132)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (109996502..110012266)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E9259 Neighboring gene predicted gene, 26808 Neighboring gene predicted gene, 57735 Neighboring gene predicted gene 15446 Neighboring gene STARR-seq mESC enhancer starr_13938 Neighboring gene STARR-seq mESC enhancer starr_13939 Neighboring gene predicted gene, 54334 Neighboring gene zinc finger protein pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. ZFP932 suppresses cellular Hedgehog response and Patched1 transcription. Huang GJ, et al. Vitam Horm, 2012. PMID 22391310
  2. Transposable Elements and Their KRAB-ZFP Controllers Regulate Gene Expression in Adult Tissues. Ecco G, et al. Dev Cell, 2016 Mar 21. PMID 27003935, Free PMC Article
  3. A novel KRAB domain-containing zinc finger transcription factor ZNF431 directly represses Patched1 transcription. He Z, et al. J Biol Chem, 2011 Mar 4. PMID 21177534, Free PMC Article
  4. TRIB3 promotes pulmonary fibrosis through inhibiting SLUG degradation by physically interacting with MDM2. Lv X, et al. Acta Pharm Sin B, 2023 Apr. PMID 37139431, Free PMC Article
  5. A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome. Mural RJ, et al. Science, 2002 May 31. PMID 12040188

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ZNF431 directly represses Patched1 expression and likely functions to repress the hedgehog response in cells
    Title: A novel KRAB domain-containing zinc finger transcription factor ZNF431 directly represses Patched1 transcription.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone deacetylase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of osteoblast differentiation TAS
Traceable Author Statement
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
zinc finger protein 431

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001374712.1 → NP_001361641.1  zinc finger protein 431 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC123679
    Consensus CDS
    CCDS89966.1
    UniProtKB/TrEMBL
    D3Z1G5
    Related
    ENSMUSP00000119843.3, ENSMUST00000125213.9
    Conserved Domains (3) summary
    COG5048
    Location:51 → 454
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:101 → 121
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:449 → 473
    zf-H2C2_2; Zinc-finger double domain

  2. NM_145563.2 → NP_663538.2  zinc finger protein 431 isoform 1

    See identical proteins and their annotated locations for NP_663538.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC123679
    Consensus CDS
    CCDS59681.1
    UniProtKB/Swiss-Prot
    E9QAG8
    Related
    ENSMUSP00000108159.2, ENSMUST00000112540.8
    Conserved Domains (4) summary
    COG5048
    Location:84 → 487
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:134 → 154
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:5 → 45
    KRAB; KRAB box
    pfam13465
    Location:482 → 506
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    110144334..110160132
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036165474.1 → XP_036021367.1  zinc finger protein 431 isoform X3

    Conserved Domains (2) summary
    COG5048
    Location:38 → 433
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:42 → 62
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. XM_036165473.1 → XP_036021366.1  zinc finger protein 431 isoform X3

    Conserved Domains (2) summary
    COG5048
    Location:38 → 433
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:42 → 62
    ZF_C2H2; C2H2 Zn finger [structural motif]

  3. XM_036165470.1 → XP_036021363.1  zinc finger protein 431 isoform X2

    UniProtKB/TrEMBL
    D3Z1G5
    Conserved Domains (3) summary
    COG5048
    Location:51 → 454
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:101 → 121
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:449 → 473
    zf-H2C2_2; Zinc-finger double domain

  4. XM_017321093.2 → XP_017176582.1  zinc finger protein 431 isoform X2

    UniProtKB/TrEMBL
    D3Z1G5
    Conserved Domains (3) summary
    COG5048
    Location:51 → 454
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:101 → 121
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:449 → 473
    zf-H2C2_2; Zinc-finger double domain

  5. XM_017321092.2 → XP_017176581.1  zinc finger protein 431 isoform X1

    UniProtKB/TrEMBL
    A0AA74KT52
    Conserved Domains (4) summary
    COG5048
    Location:83 → 486
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:133 → 153
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:4 → 44
    KRAB; KRAB box
    pfam13465
    Location:481 → 505
    zf-H2C2_2; Zinc-finger double domain

  6. XM_036165472.1 → XP_036021365.1  zinc finger protein 431 isoform X3

    Conserved Domains (2) summary
    COG5048
    Location:38 → 433
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:42 → 62
    ZF_C2H2; C2H2 Zn finger [structural motif]

  7. XM_036165471.1 → XP_036021364.1  zinc finger protein 431 isoform X2

    UniProtKB/TrEMBL
    D3Z1G5
    Conserved Domains (3) summary
    COG5048
    Location:51 → 454
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:101 → 121
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:449 → 473
    zf-H2C2_2; Zinc-finger double domain

  8. XM_017321095.3 → XP_017176584.1  zinc finger protein 431 isoform X3

    Conserved Domains (2) summary
    COG5048
    Location:38 → 433
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:42 → 62
    ZF_C2H2; C2H2 Zn finger [structural motif]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
E9QAG8.1 GenPept UniProtKB/Swiss-Prot:E9QAG8

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